Radiomics Features of ¹⁸F-fluorodeoxyglucose Positron-Emission Tomography as a Novel Prognostic Signature in Colorectal Cancer

Abstract

Word count: 3976 Number of tables: 5 Running Title: Radiomics of PET in colorectal cancer Abstract Purpose: The aim of this study was to investigate the prognostic value of radiomics signatures derived from 18 F-fluorodeoxyglucose ( 18 F-FDG) positron-emission tomography (PET) in patients with colorectal cancer (CRC). , we identified CRC patients who underwent 18 F-FDG-PET before starting any neoadjuvant treatments and surgery. Radiomics features were extracted from the primary lesions identified on 18 F-FDG-PET. Patients were divided into a training and a validation set by random sampling. A least absolute shrinkage and selection operator (LASSO) Cox regression model was applied for prognostic signature building with progression-free survival (PFS) using the training set. Using the calculated radiomics score, a nomogram was developed, and the clinical utility of this nomogram was assessed in the validation set. Results: Three-hundred-and-eight-one patients with surgically resected CRC patients (training set 228 vs. validation set 153) were included. In the training set, a radiomics signature called a rad_score was generated using two PET-derived features such as Gray Level Run Length Matrix_Long-Run Emphasis (GLRLM_LRE) and Grey-Level Zone Length Matrix_Short-Zone Low Gray-level Emphasis (GLZLM_SZLGE). Patients with a high-rad_score in the training and validation set had shorter PFS.Multivariable analysis revealed that the rad_score was an independent prognostic factor in both training and validation sets. A radiomics nomogram, developed using rad_score, nodal stage, and lymphovascular invasion, showed good performance in the calibration curve and comparable predictive power with the staging system in the validation set. Conclusion:Textural features derived from 18 F-FDG-PET images may enable more detailed stratification of prognosis in patients with CRC.