Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment

Nardone, Valerio; Boldrini, Luca; Grassi, Roberta; Franceschini, Davide; Morelli, I.; Becherini, Carlotta; Loi, Mauro; Greto, Daniela; Desideri, Isacco

doi:10.3390/cancers13143590

Cited by 26 publications

(16 citation statements)

References 194 publications

(227 reference statements)

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“…The results of our study are in line with previous studies [ 3 , 4 , 13 , 15 , 23 , 25 , 26 , 30 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]; however, as a difference, we specifically addressed segmentation variability with a fixed CT device but analysed the dependence on bin-width, distance, resolution or interpolator.…”

Section: Discussionsupporting

confidence: 88%

Robustness of Radiomics in Pre-Surgical Computer Tomography of Non-Small-Cell Lung Cancer

Belfiore

Sansone

Monti

et al. 2022

JPM

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Background: Radiomic features are increasingly used in CT of NSCLC. However, their robustness with respect to segmentation variability has not yet been demonstrated. The aim of this study was to assess radiomic features agreement across three kinds of segmentation. Methods: We retrospectively included 48 patients suffering from NSCLC who underwent pre-surgery CT. Two expert radiologists in consensus manually delineated three 3D-ROIs on each patient. To assess robustness for each feature, the intra-class correlation coefficient (ICC) across segmentations was evaluated. The ‘sensitivity’ of ICC upon some parameters affecting features computation (such as bin-width for first-order features and pixel-distances for second-order features) was also evaluated. Moreover, an assessment with respect to interpolator and isotropic resolution was also performed. Results: Our results indicate that ‘shape’ features tend to have excellent agreement (ICC > 0.9) across segmentations; moreover, they have approximately zero sensitivity to other parameters. ‘First-order’ features are in general sensitive to parameters variation; however, a few of them showed excellent agreement and low sensitivity (below 0.1) with respect to bin-width and pixel-distance. Similarly, a few second-order features showed excellent agreement and low sensitivity. Conclusions: Our results suggest that a limited number of radiomic features can achieve a high level of reproducibility in CT of NSCLC.

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Section: Discussionsupporting

confidence: 88%

Robustness of Radiomics in Pre-Surgical Computer Tomography of Non-Small-Cell Lung Cancer

Belfiore

Sansone

Monti

et al. 2022

JPM

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“…DWI is also usually performed along with traditional MRI sequences offering higher resolution; more advanced MRI devices operating with higher intensity magnetic fields offer the prospect of higher resolution images [55]. Finally, the use of artificial intelligence (AI)-based solutions in healthcare has already begun to change established paradigms across the entire healthcare sector [56][57][58][59][60]. Further studies will also be needed to address the relatively new field of radionics, in particular as applied to MRI and DWI.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted imaging and apparent diffusion coefficient mapping of head and neck lymph node metastasis: a systematic review

Belfiore

Nardone

D’Onofrio³

et al. 2022

Exploration of Targeted Anti-Tumor Therapy

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Aim: Head and neck squamous cell cancer (HNSCC) is the ninth most common tumor worldwide. Neck lymph node (LN) status is the major indicator of prognosis in all head and neck cancers, and the early detection of LN involvement is crucial in terms of therapy and prognosis. Diffusion-weighted imaging (DWI) is a non-invasive imaging technique used in magnetic resonance imaging (MRI) to characterize tissues based on the displacement motion of water molecules. This review aims to provide an overview of the current literature concerning quantitative diffusion imaging for LN staging in patients with HNSCC. Methods: This systematic review performed a literature search on the PubMed database (https://pubmed.ncbi.nlm.nih.gov/) for all relevant, peer-reviewed literature on the subject following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) criteria, using the keywords: DWI, MRI, head and neck, staging, lymph node. Results: After excluding reviews, meta-analyses, case reports, and bibliometric studies, 18 relevant papers out of the 567 retrieved were selected for analysis. Conclusions: DWI improves the diagnosis, treatment planning, treatment response evaluation, and overall management of patients affected by HNSCC. More robust data to clarify the role of apparent diffusion coefficient (ADC) and DWI parameters are needed to develop models for prognosis and prediction in HNSCC cancer using MRI.

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“…In recent years, through its ability to assemble and quickly analyze enormous volumes of data generated by imaging studies, artificial intelligence (AI) has begun to transform the practice of radiology. Throughout the field, applications leveraging AI are used to improve diagnostic accuracy, imaging consistency, workflow efficiency, and patient care by automating many formerly tedious, time consuming, and manually performed tasks [20][21][22][23][24]. Radiomics is an emerging field of radiology and can be coupled with AI.…”

Section: Discussionmentioning

confidence: 99%

Computed Tomography Structured Reporting in the Staging of Lymphoma: A Delphi Consensus Proposal

Granata

Pradella

Cozzi

et al. 2021

JCM

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Structured reporting (SR) in radiology is becoming increasingly necessary and has been recognized recently by major scientific societies. This study aims to build structured CT-based reports for lymphoma patients during the staging phase to improve communication between radiologists, members of multidisciplinary teams, and patients. A panel of expert radiologists, members of the Italian Society of Medical and Interventional Radiology (SIRM), was established. A modified Delphi process was used to develop the SR and to assess a level of agreement for all report sections. The Cronbach’s alpha (Cα) correlation coefficient was used to assess internal consistency for each section and to measure quality analysis according to the average inter-item correlation. The final SR version was divided into four sections: (a) Patient Clinical Data, (b) Clinical Evaluation, (c) Imaging Protocol, and (d) Report, including n = 13 items in the “Patient Clinical Data” section, n = 8 items in the “Clinical Evaluation” section, n = 9 items in the “Imaging Protocol” section, and n = 32 items in the “Report” section. Overall, 62 items were included in the final version of the SR. A dedicated section of significant images was added as part of the report. In the first Delphi round, all sections received more than a good rating (≥3). The overall mean score of the experts and the sum of score for structured report were 4.4 (range 1–5) and 1524 (mean value of 101.6 and standard deviation of 11.8). The Cα correlation coefficient was 0.89 in the first round. In the second Delphi round, all sections received more than an excellent rating (≥4). The overall mean score of the experts and the sum of scores for structured report were 4.9 (range 3–5) and 1694 (mean value of 112.9 and standard deviation of 4.0). The Cα correlation coefficient was 0.87 in this round. The highest overall means value, highest sum of scores of the panelists, and smallest standard deviation values of the evaluations in this round reflect the increase of the internal consistency and agreement among experts in the second round compared to first round. The accurate statement of imaging data given to referring physicians is critical for patient care; the information contained affects both the decision-making process and the subsequent treatment. The radiology report is the most important source of clinical imaging information. It conveys critical information about the patient’s health and the radiologist’s interpretation of medical findings. It also communicates information to the referring physicians and records this information for future clinical and research use. The present SR was generated based on a multi-round consensus-building Delphi exercise and uses standardized terminology and structures, in order to adhere to diagnostic/therapeutic recommendations and facilitate enrolment in clinical trials, to reduce any ambiguity that may arise from non-conventional language, and to enable better communication between radiologists and clinicians.

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Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment

Cited by 26 publications

References 194 publications

Robustness of Radiomics in Pre-Surgical Computer Tomography of Non-Small-Cell Lung Cancer

Robustness of Radiomics in Pre-Surgical Computer Tomography of Non-Small-Cell Lung Cancer

Diffusion-weighted imaging and apparent diffusion coefficient mapping of head and neck lymph node metastasis: a systematic review

Computed Tomography Structured Reporting in the Staging of Lymphoma: A Delphi Consensus Proposal

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