Radionuclide‐Activated Nanomaterials and Their Biomedical Applications

Ferreira, Carolina A.; Ni, Dalong; Rosenkrans, Zachary T.; Cai, Weibo

doi:10.1002/anie.201900594

Cited by 55 publications

(44 citation statements)

References 95 publications

(231 reference statements)

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“…One of the radionuclide decay products is high-speed charged particles that move faster than the light in that medium, originating a faint luminescence in the UV-blue region of the electromagnetic spectrum called Cerenkov luminescence. Thus, the development of systems containing radionuclides yields an internal light excitation source [ 285 , 286 , 287 , 288 ]. Sun, Su, and co-workers recently reported using Cerenkov luminescence to generate PeL using the system 131 I–ZnGa 2 O 4 :Cr III –ZnPcC4 [ 289 ].…”

Section: Persistent Luminescence In Luminescence Imaging Of Biologmentioning

confidence: 99%

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

et al. 2020

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The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminescence imaging, there is no need for continuous excitation to avoid tissue and cell damage due to the continuous light exposure, and they also circumvent the depth penetration issue caused by excitation in the UV-Vis. This review aims to provide a background in luminescence imaging of biological systems, persistent luminescence, and synthetic methods for obtaining persistent luminescent materials, and discuss selected examples of recent literature on the applications of persistent luminescent materials in luminescence imaging of biological systems and photodynamic therapy. Finally, the challenges and future directions, pointing to the development of compounds capable of executing multiple functions and light in regions where tissues and cells have low absorption, will be discussed.

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Section: Persistent Luminescence In Luminescence Imaging Of Biologmentioning

confidence: 99%

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

et al. 2020

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“…Radionuclides emitting β particles with relatively higher energy, such as 68 Ga and 90 Y, would produce CR with higher intensity (Klein et al, 2019 ). In recent years, the Cerenkov phenomenon for biomedical applications (i.e., imaging and therapy) has gradually garnered significant attention, especially combining the rapid advancements in nanosciences and nanotechnologies (Shaffer et al, 2017 ; Cline et al, 2019 ; Ferreira et al, 2019 ).…”

Section: Cerenkov Radiation-induced Photodynamic Therapymentioning

confidence: 99%

“…Internal light sources have emerged as an attractive alternative to outer light sources in a conventional PDT system for addressing the issue of light penetration (Magalhães et al, 2016 ; Ferreira et al, 2019 ). Some self-illuminating systems, including chemiluminescence (CL), bioluminescence (BL), and Cerenkov radiation (CR), are promising candidates as internal light sources for PDT as these self-illuminators are small in size (ranging from atomic/molecular to nanometer scale) and thus can be delivered to any pathological tissues.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy of Cancers With Internal Light Sources: Chemiluminescence, Bioluminescence, and Cerenkov Radiation

et al. 2020

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Photodynamic therapy (PDT) is a promising and minimally invasive modality for the treatment of cancers. The use of a self-illuminating system as a light source provides an intriguing solution to the light penetration issues of conventional PDT, which have gained considerable research interest in the past few years. This mini review aimed to present an overview of self-illuminating PDT systems by using internal light sources (chemiluminescence, bioluminescence, and Cerenkov radiation) and to give a brief discussion on the current challenges and future perspectives.

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“…In any case, considering the form of energy reaching and emitted by the NPs, interactions can be categorized into two processes: photon–photon and beta–photon emission. For a detailed description of the physical processes behind each kind of interaction, see the work of Pratt et al [ 25 ] and the complete review of Ferreira et al [ 39 ].…”

Section: Nanoparticles For Imaging and Therapy Using Cerenkov Sourmentioning

confidence: 99%

Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy

Boschi

Spinelli

2020

Nanomaterials

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Cerenkov luminescence imaging and Cerenkov photodynamic therapy have been developed in recent years to exploit the Cerenkov radiation (CR) generated by radioisotopes, frequently used in Nuclear Medicine, to diagnose and fight cancer lesions. For in vivo detection, the endpoint energy of the radioisotope and, thus, the total number of the emitted Cerenkov photons, represents a very important variable and explains why, for example, 68Ga is better than 18F. However, it was also found that the scintillation process is an important mechanism for light production. Nanotechnology represents the most important field, providing nanosctructures which are able to shift the UV-blue emission into a more suitable wavelength, with reduced absorption, which is useful especially for in vivo imaging and therapy applications. Nanoparticles can be made, loaded or linked to fluorescent dyes to modify the optical properties of CR radiation. They also represent a useful platform for therapeutic agents, such as photosensitizer drugs for the production of reactive oxygen species (ROS). Generally, NPs can be spaced by CR sources; however, for in vivo imaging applications, NPs bound to or incorporating radioisotopes are the most interesting nanocomplexes thanks to their high degree of mutual colocalization and the reduced problem of false uptake detection. Moreover, the distance between the NPs and CR source is crucial for energy conversion. Here, we review the principal NPs proposed in the literature, discussing their properties and the main results obtained by the proponent experimental groups.

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Radionuclide‐Activated Nanomaterials and Their Biomedical Applications

Cited by 55 publications

References 95 publications

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

Photodynamic Therapy of Cancers With Internal Light Sources: Chemiluminescence, Bioluminescence, and Cerenkov Radiation

Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy

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