Radionuclide Angiography for the Diagnosis of Thyroid Cancer

Lee, Victor W.

doi:10.1001/archsurg.1982.01380330086021

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Radionuclide angiography, in addition to FNAC, is employed as a standard procedure at our centre to differentiate benign from malignant thyroid nodules on the basis of their arterial perfusion (Prakash ef al 1985). Hypervascularity in the form of increased Tc-99m pertechnetate flow through a functionally cold solitary thyroid nodule is a sensitve indicator of malignancy (Aggarwal e t al 1989; Lee and Shapiro 1982). Radionuclide angiography was not considered in the initial investigation of this patient as the clinical presentation, thyroid hormonal profile and scan findings were suggestive of subacute thyroiditis.…”

Section: Case Reportmentioning

confidence: 99%

Follicular Thyroid Carcinoma Masquerading as Subacute Thyroiditis Diagnosis using Ultrasonography and Radionuclide Thyroid Angiography

Prakash

Jayaram

Singh

1991

Australasian Radiology

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The rare presentation of a follicular thyroid carcinoma mimicking the clinical and radionuclide features of subacute thyroiditis is described. Granulomatous thyroiditis was initially suspected on the clinical basis of acute onset of a hard, tender right lobe thyroid enlargement with associated systemic symptoms, modest elevation of thyroid hormone levels and suppressed thyroid RAIU. Fine needle aspiration cytology specimens were unsatisfactory for characterization. Three weeks later the thyroid RAIU was normal. The thyroid enlargement persisted, now being clearly visualized as a hypofunctional nodule on scintiscan. Repeat fine needle aspiration cytology was suggestive of acinar proliferation with hyperfunction. Ultrasonography revealed a solid nodule with a peripheral sonolucent halo. Radionuclide angiography showed intense arterial flow of Tc-99m pertechnetate through the right lobe thyroid enlargement suggestive of malignant thyroid pathology. Surgical excision and histopathological examination revealed a follicular carcinoma involving the right lobe. The possibility of carcinomatous involvement should be considered in those patients where initially tender thyroid nodularity persists longer than expected for a benign inflammatory disease, careful follow-up and relevant investigations being necessary to confirm the diagnosis.

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Section: Case Reportmentioning

confidence: 99%

Follicular Thyroid Carcinoma Masquerading as Subacute Thyroiditis Diagnosis using Ultrasonography and Radionuclide Thyroid Angiography

Prakash

Jayaram

Singh

1991

Australasian Radiology

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“…In 1982, Lee and Shapiro13 reported on the usefulness of dynamic flow studies in accurately diagnosing Graves' and Plummer's diseases, based on their hypervascularity.13 They later reported three cases of thyroid carcinoma in solitary cold nodules with marked hypervasculari¬ ty on dynamic flow studies. 14 To determine if radionuclide angi¬ ography improves the differentiation between benign and malignant thy¬ roid nodules, we performed a fiveyear study of patients entering our institution for thyroid surgery. The results of the scans were correlated with pathology findings noted at exci¬ sional biopsy.…”

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confidence: 99%

Radionuclide Thyroid Angiography and Surgical Correlation: A Five-Year Study

Moe¹,

Frankel²,

Chacko³

et al. 1984

Archives of Otolaryngology - Head and Neck Surgery

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III \s=b\Only 15% to 25% of cold nodules on conventional static thyroid scans are malignant. Radionuclide angiography of the thyroid and conventional static scans using sodium pertechnetate Tc 99m were performed on 114 patients who underwent thyroid surgery within a five-year period. The combined use of radionuclide angiography and conventional static scans increased the specificity for the diagnosis of thyroid carcinoma from 42% to 79% over static scans alone. The incidence of carcinoma in solitary cold nodules in our population was increased from 26% on static scans to 60% if the lesion was hypervascular on radionuclide angiography. Eighty-seven percent of hypervascular solitary cold nodules were neoplasms (carcinomas and adenomas). Hypervascularity as demonstrated by radionuclide angiography is predictive of thyroid neoplasia. The finding of a hypervascular, solitary cold nodule makes a recommendation for surgery predictive and reasonable. (Arch Otolaryngol 1984;110:717-720) Thyroid nodules have been evalu¬ ated for nearly 20 years with stat¬ ic radionuclide thyroid scans using sodium pertechnetate (Tc 99m). Stud¬ ies have shown that 15% to 25% of all cold (hypofunctioning) nodules are malignant. A lower incidence of malignant neoplasms has been re¬ ported in solitary, warm or hot nod¬ ules and in multinodular thyroid glands. Numerous methods, including patient selection techniques,1·2 ultrasonography,3 fluorescent scanning, needle biopsy, and use of other radionuclides,4 6 have been examined to fur¬ ther differentiate benign from malig¬ nant thyroid nodules.Conventional contrast angiogra-

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Computer-assisted radionuclide perfusion study in solitary cold thyroid nodules for diagnosis of malignancy

et al. 1985

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A computer-assisted radionuclide perfusion study was performed in 25 cases of solitary 'cold' thyroid nodules to assess their vascularity relative to that of normal adjoining thyroid tissue. Hypervascularity was seen in 3 malignant nodules; 1 follicular adenoma also showed increased vascularity. The 21 nodules demonstrating equal vascularity or avascularity with respect to normal thyroid tissue were benign in nature. Computer-generated time-activity curves were helpful in distinguishing hypervascular from equally vascular nodules. This technique, in conjunction with clinical evaluation, can be of value in deciding whether patients should undergo surgery or receive conservative management.

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Radionuclide Angiography for the Diagnosis of Thyroid Cancer

Cited by 3 publications

References 15 publications

Follicular Thyroid Carcinoma Masquerading as Subacute Thyroiditis Diagnosis using Ultrasonography and Radionuclide Thyroid Angiography

Follicular Thyroid Carcinoma Masquerading as Subacute Thyroiditis Diagnosis using Ultrasonography and Radionuclide Thyroid Angiography

Radionuclide Thyroid Angiography and Surgical Correlation: A Five-Year Study

Computer-assisted radionuclide perfusion study in solitary cold thyroid nodules for diagnosis of malignancy

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