Radionuclide-based Cerenkov luminescence in biomedicine: Current research progress and future perspectives

Xu, Pei; Lin, Subin; Wang, Yangyun; Abdukayum, Abdukader; Wang, Yong

doi:10.1016/j.trac.2023.117452

Cited by 3 publications

(2 citation statements)

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“…Almost β + decaying nuclides are capable of producing Cerenkov luminescence (CL), allowing their optical signals to be captured by highly sensitive optical equipment. 33 We first explored the CL imaging ability of 177 Lu/Mn-HAP in vitro. The results, as depicted in Figure S13D, demonstrated a great linear relationship between the optical signal and radioactivity.…”

Section: Resultsmentioning

confidence: 99%

“…Conversely, 177 Lu/Mn-HAP concentrated radioactivity within the tumor site, with no significant presence in other organs and tissues (Figure S13C). Almost β + decaying nuclides are capable of producing Cerenkov luminescence (CL), allowing their optical signals to be captured by highly sensitive optical equipment . We first explored the CL imaging ability of 177 Lu/Mn-HAP in vitro .…”

Section: Resultsmentioning

confidence: 99%

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Radioactive Hydroxyapatite Microspheres Empower Sustainable In Situ Tumor Vaccination

Xu,

Gu,

et al. 2024

ACS Nano

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Tumor in situ vaccination (ISV) strategies have emerged in clinical trials as promising approaches, involving the release of tumor antigens through local radiotherapy and intratumorally adjuvant injections. However, the current fabrication strategy for achieving a sustainable immune response to ISV remains a pressing challenge. In this study, we present an empowered sustainable ISV method for antitumor therapy using 177 Lu-labeled manganesedoped mesoporous hydroxyapatite ( 177 Lu/Mn-HAP) microspheres. The ISV enables the sustained utilization of tumor antigens, leading to the activation of dendritic cells and polarization of macrophages toward the M1 subtype. Consequently, it facilitates the generation of potent CD8 + T-cell responses, enhancing the antitumor effects of internal radiation in both primary and distant tumors. Importantly, this approach achieves complete remission in all tumorbearing mice and stimulates immune memory to prevent tumor recurrence. Our study highlights a universal and safe ISV strategy capable of inducing potent tumor-specific and sustainable immune response.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Radioactive Hydroxyapatite Microspheres Empower Sustainable In Situ Tumor Vaccination

Xu,

Gu,

et al. 2024

ACS Nano

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Optical imaging for brown or beige adipose tissue

Liu,

Ni,

Peng

et al. 2024

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Currently, one in three adults worldwide may be obese or overweight. Obesity is characterized by an excess of energy‐storing white fat. An ingenious and sought‐after strategy against obesity is to activate energy‐consuming beige fat, which is converted from white fat or brown fat. However, existing tools for assessing brown or beige fat activation in vivo have certain limitations, such as being cumbersome and expensive. Optical imaging is a relatively straightforward and economical imaging technique that utilizes light to peer into the structural–functional information of living organisms at multiple scales. Despite the availability of various optical imaging modalities for detecting brown or beige fat, there is a dearth of literature summarizing relevant studies. Accordingly, this review focuses on these optical modalities and elaborates on their imaging principles, characteristics, and recent research advances in the detection of brown or beige fat. Their imaging targets, advantages, and disadvantages are further concluded. As a methodological reference, this review can guide the selection of optimal optical modalities to noninvasively profile brown or beige fat activation from a specific biological perspective, maximizing the potential of optical imaging in anti‐obesity assessment.

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