Radionuclide bone scanning of osteosarcoma: falsely extended uptake patterns

Bone Scintigraphy and Panoramic Radiography in Deciding the Extent of Bone Resection in Benign Jaw Lesions

“…Although several authors [2,27,28] have been using bone scan as an index for detecting the correct extent of the lesion, in order to ensure adequate surgical resection, others have shown that an "extended uptake" occurred beyond the proven limits of focal bone destruction [29][30][31]. In our case, two false positive uptakes which had occurred due to corresponding dental infections were correctly identified when BS was correlated with PR.…”

Different Uptake Patterns of Tc-99m MDP on Three Phase Bone Scan in a Neurofibromatosis Type I Patient with Multiple Neurofibromas and Neurofibrosarcoma: Case Report

“…Blood flow increase and hyperemia is frequently seen in these cases and blood flow increase is of diagnostic value in differentiation of malignity on bone scintigraphy. 26 In some cases, blood flow increase and hyperemia can be the only warning sign on bone scan and even no significant osteoblastic activity retention may be detected on late phase bone scan. 27 Our case was also an example for showing the value of blood flow increase and hyperemia in differentiating malignancy.…”

Nuclear Medicine in Musculoskeletal Disorders: Clinical Approach

“…In general, 18F-FDG-PET or PET/CT would appear to have a complementary role to conventional staging procedures (Cook et al, 2010;as cited in Kleis et al, 2009, Kneisl et al, 2006and Völker et al, 2007. After a diagnosis of a malignant primary bone lesion is made, the use of bone scintigraphy to define the extent of tumor before surgical resection is controversial: good correlation between increased bone tracer uptake and true anatomical extent that has been reported (Cook et al, 2010;as cited in Goldmann et al, 1975, McKillop et al, 1981, and Papanicolou et al, 1982, has not been supported by other studies (Chew & Hudson, 1982). These discrepancies may be due to peritumoral reactive changes overestimating extent or underestimations due to inability to detect marrow and soft-tissue involvement.…”