Radionuclide Evaluation of Changes in Myocardial Sympathetic  Activity in Patients With Atrial Fibrillation and Healthy Individuals  Using a Gamma Camera on CZT Detectors

Минин, С. М.; Nikitin, Nikita; Шабанов, В В; Losik, Denis; Mikheenko, I.; Покушалов, Е А; Romanov, Alexander

doi:10.21569/2222-7415-2018-8-2-30-39

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“…В зависимости от формы и продолжительности фибрилляция предсердий может не только негативно влиять на системную гемодинамику, ухудшать прогноз жизни больного, но и проводить к значительному числу серьезных осложнений и смерти. Немаловажную роль в этом играют изменения нейрональной функции сердца, в частности дисрегуляции симпатического звена вегетативной нервной системы [2,3].…”

Section: Introductionunclassified

Possibilities of single-photon emission computed tomography for the assessment of cardiac global and regional sympathetic activity in patients with atrial fibrillation

Минин¹,

Nikitin²,

Покушалов³

et al. 2019

PKiK

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<div><strong>Aim.</strong> To evaluate global and regional sympathetic activity in patients with atrial fibrillation using <sup>123</sup>I-metaiodbenzylguanidine (<sup>123</sup>I-MIBG) scintigraphy before and after catheter ablation.</div><div><strong>Methods.</strong> A total of 45 patients with paroxysmal and persistent atrial fibrillation (mean age, 55 ± 10 years; 44% women) followed up till catheter ablation were included in the study. All study participants underwent <sup>123</sup>I-MIBG scintigraphy within 1–2 days before and 5–7 days after catheter ablation. The global myocardial sympathetic activity was estimated by calculating the ratio of <sup>123</sup>I-MIBG uptake in the heart and mediastinum in the early and delayed phases (H/Me and H/Md), as well as the <sup>123</sup>I-MIBG wash out rate in 4 h (WR). Regional sympathetic activity was estimated by semiquantitative analysis of the 123I-MIBG uptake in the myocardium of the left ventricle.</div><div><strong>Results.</strong> Baseline <sup>123</sup>I-MIBG scintigraphy showed the difference between paroxysmal and persistent atrial fibrillation patients in WR only (19.2 ± 6.4 and 23.9 ± 7.2, respectively; p = 0.03). A statistically significant decrease of H/Md in average of 0.1 (95% confidence interval, 0.02–0.2; p = 0.02) was found in patients with paroxysmal atrial fibrillation, and a decrease of WR in average of 3.7% (95% confidence interval, −7% to −0.4%; p = 0.03) after catheter ablation. No statistically significant changes of H/Md and WR were found in patients with persistent atrial fibrillation after catheter ablation. The analysis of regional 123I-MIBG uptake in the left ventricular myocardium did not show any statistically significant changes in the regional sympathetic activity after catheter ablation compared with that at baseline.</div><div><strong>Conclusion.</strong> The differences in WR only were found between patients with paroxysmal and persistent atrial fibrillation. Significant changes in myocardial sympathetic activity after catheter ablation were found only in patients with paroxysmal atrial fibrillation, a finding that may be associated with a large number of active sympathetic nerve endings in the myocardium compared with patients with persistent atrial fibrillation.</div><div>ClinicalTrials.gov Identifier: NCT02914860</div><div>Received 23 April 2019. Accepted 26 May 2019.</div><div><strong>Conflict of interest:</strong> Authors declare no conflict of interest.</div><div><strong>Funding:</strong> The study is a part of a research project supported of a grant of the Russian Science Foundation No. 17-75-20118.</div>

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Section: Introductionunclassified