Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a 131I-Labeled Polydopamine Multifunctional Nanocarrier

Abstract

Development of biocompatible nanomaterials with multiple functionalities for combination of radiotherapy and chemotherapy has attracted tremendous attention in cancer treatment. Herein, poly(ethylene glycol) (PEG) modified polydopamine (PDA) nanoparticles were successfully developed as a favorable biocompatible nanoplatform for co-loading antitumor drugs and radionuclides to achieve imaging-guided combined radio-chemotherapy. It is demonstrated that PEGylated PDA nanoparticles can effectively load two different drugs including sanguinarine (SAN) and metformin (MET), as well as radionuclides I in one system. The loaded SAN and MET could inhibit tumor growth via inducing cell apoptosis and relieving tumor hypoxia, while labeling PDA-PEG withI enables in vivo radionuclide imaging and radioisotope therapy. As revealed by the therapeutic efficacy both in cell and animal levels, the multifunctional PDA nanoparticles (I-PDA-PEG-SAN-MET) can effectively repress the growth of cancer cells in a synergistic manner without significant toxic side effects, exhibiting superior treatment outcome than the respective monotherapy. Therefore, this study provides a promising polymer-based platform to realize imaging-guided radioisotope/chemotherapy combination cancer treatment in future clinical application.

<p>¹³¹I-labeled polyethylenimine-entrapped gold nanoparticles for targeted tumor SPECT/CT imaging and radionuclide therapy</p>

“…Beta minus decay provides therapeutic effects, while gamma emissions are used for SPECT imaging 17,22,23. Therefore, 131 I-labeled molecular probes have been developed for theranostic applications in treatment of various kinds of cancer 24–27. Several studies have suggested that 131 I-labeled glioma-targeting ligands such as chlorotoxin, and chlorotoxin-like peptides such as Buthus martensii Karsch chlorotoxin (BmK CT), are potential candidates for targeted SPECT imaging and radionuclide therapy of glioma 28–31.…”

A Functionalized Polydopamine Theranostic Nanoprobe for Efficient Imaging of miRNA-21 and In Vivo Synergetic Cancer Therapy

“…PDA was synthesized from dopamine hydrochloride according to our previous protocol. 31 Transmission electron microscopy (TEM) showed that PDA nanoparticles presented uniform spherical morphology ( Figure 2 A), while the average diameter was around 200 nm as revealed by dynamic light scattering (DLS; Figure 2 B). In order to improve the biocompatibility of PDA nanoparticles, we functionalized PDA with amino PEG at pH 10.0, and the obtained PDA-PEG NPs showed excellent biocompatibility in different physiological solutions ( Figure 2 C).…”

A functionalized polydopamine theranostic nanoprobe for efficient imaging of miRNA-21 and in vivo synergetic cancer therapy

“…Synthesis and characterization of PDA-PEG-DOX nanoparticles PDA was synthesized from dopamine hydrochloride according to our previous protocol [31].…”

“…PDA nanoparticles were synthesized according to our published protocols with a little modi cation [31]. In brief, 180 mg of dopamine hydrochloride (Aldrich Chemical) was dissolved in 90 mL of deionized water, and then 760 μL of sodium hydroxide (NaOH, 1 mol L -1 ) was added.…”