Radionuclide Imaging in Chagas Cardiomyopathy

Simões, Marcus Vinı́cius; Gadioli, Leonardo Pippa; Oliveira, Luciano Fonseca Lemos de

doi:10.1007/s12410-019-9482-8

Cited by 1 publication

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“…In this scenario, 18 F-FDG PET may be a promising tool to monitor disease activity and risk stratification of patients with CC. Future studies should address these new potential clinical applications of PET imaging 73,74 (Figure 6).…”

Section: Chagas Cardiomyopathymentioning

confidence: 99%

Autonomic Innervation Evaluation in Cardiac Disease

Brito¹,

Glavam²,

Bronchtein³

et al. 2021

International Journal of Cardiovascular Sciences

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Cardiovascular diseases are among the leading causes of mortality and morbidity in the world. In different cardiac diseases, the neuronal function of the heart is impaired. Nevertheless, the development of a simple method to assess the autonomic effects on the heart and/or autonomic dysfunction is a challenge. The evaluation of autonomic innervation in cardiac diseases has helped to improve the knowledge of the pathophysiology of these conditions, as well as to provide information on their prognosis. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are currently the only imaging methods that allow in vivo assessment of cardiac innervation. The majority of SPECT and PET radiotracers evaluate sympathetic neuronal integrity using presynaptic imaging agents that are either labeled as endogenous transmitters or analogues. Postsynaptic imaging agents have also been developed to study sympathetic neuronal integrity, as well as tracers to investigate the parasympathetic nervous system. These methods may be used to analyze the innervation of the heart and allow for early detection of abnormalities caused by, for example, ischemia, heart failure, cardiomyopathies, cardiotoxicity, and arrhythmogenic disorders. This review provides an overview of cardiac innervation evaluation and their application in the assessment of heart disease. Autonomic Nervous SystemThe autonomic nervous system (ANS) is broad and extends to most organic systems. Therefore, the study of

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Section: Chagas Cardiomyopathymentioning

confidence: 99%