Radionuclide Simultaneous Dual-Isotope Stress Myocardial Perfusion Study Using the ???Three Window Technique

Yang, Dixon; Ragasa, Eliezer; Gould, Lawrence; Huang, Ming; Reddy, C.V.R.; Saul, Barry I.; Schifter, David; Rainaldi, Deborah; Feld, Carmen; Tank, Ramesh A.; Lee, Shing-Yee; Giovanniello, Joseph

doi:10.1097/00003072-199310000-00006

Cited by 21 publications

(8 citation statements)

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“…where ͑TlϩTc͒ 70 keV and ͑TlϩTc͒ 140 keV denote dual-isotope images in the respective energy windows and k is a crosstalk fraction between 140 keV and 70 keV window. The other approach for cross-talk correction is ͑in addition to cross-talk fractions͒ to use images from the third 26 and even fourth energy windows 4 to estimate cross-talk in the window of interest. The images from these additional windows, when appropriately scaled, give an estimate of cross-talk in terms of total number of counts and spatial distribution of crosstalk photons.…”

Section: Theorymentioning

confidence: 99%

Enhanced cross‐talk correction technique for simultaneous dual‐isotope imaging: A TL‐201/Tc‐99m myocardial perfusion SPECT dog study

Knešaurek

Macháč

1997

Medical Physics

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A newly developed cross-talk correction method for simultaneous dual-isotope SPECT imaging was tested in a canine model. The method is based on the assumption that the transformations, which modify the primary energy window images into the scatter images as viewed in the other energy windows, are known. These transformations were found by measuring the point spread functions (PSFs) in two different energy windows for both isotopes in water. The dual-isotope correction method is described by two convolution equations which were applied in frequency space. The equations take into account the different spatial distributions of the primary and scatter cross-talk photons. The new enhancement of the method was in applying restoration filters to the resulting corrected images. Three separate studies were acquired in our dog study: two single-isotope and one dual-isotope study. The single isotope images were used as references. The contrast between the left ventricle cavity (LVC) and the myocardium was used in transaxial and short-axis slices as a parameter to evaluate results of dual-isotope correction method with restoration. The change in contrast in the dual-isotope corrected images in both energy windows, i.e., Tc-99m primary window (140 keV) and Tl-201 primary window (70 keV), was significant. The only exception was for the short-axis Tc-99m window images. The corrected 140 keV dual-isotope short-axis slice had the contrast of 0.60 vs 0.58, which was the value in the noncorrected dual-isotope short-axis slice. For dual-isotope 140 keV transaxial slice, the contrast changed from 0.72 to 0.82 after correction. In comparison, for single-isotope Tc-99m 140 keV transaxial slice, contrast changed from 0.62 to 0.84 after restoration correction. There was less change in contrast in the short-axis Tc-99m 140 keV slice, i.e., from 0.56 to 0.61. In the Tl-201 primary window for the transaxial slices the improvement of contrast was from 0.38 to 0.64, and for short-axis slices from 0.22 to 0.32 after correction. In the same 70 keV energy window for single-isotope Tl-201 images, contrast improved from 0.61 to 0.69 and from 0.35 to 0.38 for transaxial and short-axis slice, respectively, after applying restoration correction. In conclusion, the presented dual-isotope correction method with restoration improves the quality of the simultaneous rest Tl-201/stress Tc-99m sestamibi SPECT imaging.

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Section: Theorymentioning

confidence: 99%

Enhanced cross‐talk correction technique for simultaneous dual‐isotope imaging: A TL‐201/Tc‐99m myocardial perfusion SPECT dog study

Knešaurek

Macháč

1997

Medical Physics

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“…The study protocol was stress 99m Tc/rest 201 Tl, which is the most common protocol. In the rest 99m Tc/stress 201 Tl protocol (Yang et al 1993), mutual cross-talk between 99m Tc and 201 Tl can be slightly different. Our dog rest/rest study estimated 99m Tc cross-talk in the 70 keV 201 Tl window at around 30% and 201 Tl cross-talk in the 140 keV 99m Tc window at around 5%.…”

Section: Introductionmentioning

confidence: 99%

Comparison of correction techniques for simultaneous²⁰¹Tl/^99mTc myocardial perfusion SPECT imaging: a dog study

Knešaurek¹,

Macháč

2000

Phys. Med. Biol.

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We compared two correction methods for simultaneous 201Tl/99mTc dual-isotope single-photon emission computed tomography (SPECT). Both approaches use the information from the third energy window placed between the photopeak windows of the 201Tl and 99mTc. The first approach, described by Moore et al, corrects only for the contribution of the 99mTc to the 201Tl primary 70 keV window. We developed the three-window transformation dual isotope correction method, which is a simultaneous cross-talk correction. The two correction methods were compared in a simultaneous 201Tl/99mTc sestamibi cardiac dog study. Three separate acquisitions were performed in this dog study: two single-isotope and one dual-isotope acquisition. The 201Tl single-isotope images were used as references. The total number of counts, and the contrast between the left ventricular cavity (LVC) and the myocardium, were used in 70 keV short axis slices as parameters for evaluating the results of the dual-isotope correction methods. Three consecutive short-axis slices were used to calculate averaged contrast and the averaged total number of counts. The total number of the counts was 667000+/-500 and 414500+/-400 counts for the dual isotope (201Tl+/-99mTc) and single-isotope (201Tl-only) 70 keV images, respectively. The corrected dual-isotope images had 514700+/-700 and 368000+/-600 counts for Moore's correction and our approach, respectively. Moore's method improved contrast in the dual isotope 70 keV image to 0.14+/-0.03 from 0.11+/-0.02, which was the value in the 70 keV non-corrected dual-isotope image. Our method improved the same contrast to 0.22+/-0.03. The contrast in the 201Tl single-isotope 70 keV image was 0.28+/-0.02. Both methods improved the 70 keV dual-isotope images. However, our approach provided slightly better images than Moore's correction when compared with 201Tl-only 70 keV images.

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“…A number of researchers have investigated using subtraction-based or restoration-based methods to compensate for the effects of cross-talk in simultaneous Tc-99m / Tl-201 imaging (Yang et al, 1993;Knesaurek, 1994;Hademenos et al, 1995;Moore et al, 1995;Links et al, 1996). These methods involve estimating the cross-contamination component and either subtracting or deconvolving the data to yield an uncontaminated result.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects

1999

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Simultaneous acquisition of dual-isotope SPECT data offers a number of advantages over separately acquired data; however, simultaneous acquisition can result in cross-contamination between isotopes. In this work we propose and evaluate two frameworks for iterative model-based compensation of cross-contamination in dual-isotope SPECT. The methods were applied to cardiac imaging with Technetium-99m-sestamibi and Thallium-201, and they were compared to a subtraction-based compensation method using a cross-talk estimate obtained from an auxiliary energy window. Monte Carlo simulations were performed to carefully study aspects of bias and noise for the methods, and a torso phantom with cardiac insert was used to evaluate the performance of the methods for experimentally acquired data. The cross-talk compensation methods substantially improved lesion contrast and significantly reduced quantitative errors for simultaneously acquired data. Thallium image normalized mean square error (NMSE) was reduced from 0.522 without cross-talk compensation to as low as 0.052 with model-based cross-talk compensation. This is compared to a NMSE of 0.091 for the subtraction-based compensation method. The application of a preliminary model for crosstalk arising from lead fluorescence x-rays and collimator scatter gave promising results, and the future development of a more accurate model for collimator interactions would likely benefit simultaneous Tc/Tl imaging. Model-based compensation methods provide feasible cross-talk compensation in clinically acceptable times, and they may ultimately make simultaneous dualisotope protocols an effective alternative for many imaging procedures.

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Radionuclide Simultaneous Dual-Isotope Stress Myocardial Perfusion Study Using the ???Three Window Technique

Cited by 21 publications

References 0 publications

Enhanced cross‐talk correction technique for simultaneous dual‐isotope imaging: A TL‐201/Tc‐99m myocardial perfusion SPECT dog study

Enhanced cross‐talk correction technique for simultaneous dual‐isotope imaging: A TL‐201/Tc‐99m myocardial perfusion SPECT dog study

Comparison of correction techniques for simultaneous²⁰¹Tl/^99mTc myocardial perfusion SPECT imaging: a dog study

Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects

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Radionuclide Simultaneous Dual-Isotope Stress Myocardial Perfusion Study Using the ???Three Window Technique

Cited by 21 publications

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Enhanced cross‐talk correction technique for simultaneous dual‐isotope imaging: A TL‐201/Tc‐99m myocardial perfusion SPECT dog study

Enhanced cross‐talk correction technique for simultaneous dual‐isotope imaging: A TL‐201/Tc‐99m myocardial perfusion SPECT dog study

Comparison of correction techniques for simultaneous201Tl/99mTc myocardial perfusion SPECT imaging: a dog study

Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects

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Comparison of correction techniques for simultaneous²⁰¹Tl/^99mTc myocardial perfusion SPECT imaging: a dog study