“…This latter development suggested that general multi-compartment analysis might not have to be restricted to contiguous topologies a t all and that integral equation approaches previously principally restricted either to two-compartment systems, vascular flow treatments, and individual parameter (i.e. volume) determinations (10,11,12,13,14,15), or focussed essentially on the inverse problem of predicting the tracer time dependencies from known transfer characteristics (16) could in fact be adapted to solve stead y-state, non-contiguous, multi-compartment s y s tems 017, 18 ) i n the s e n s e that all the actually determinable intercompartment transfer ~ properties of generally injectable systems could be specified. While the resulting integral equation approach permitted analysis of many previously rather intratable s y s tems, two difficulties remained.…”