Radionuclide ventriculographic study of adaptations to exercise in aortic regurgitation

Steingart, Richard M.; Yee, Corine; Weinstein, Lawrence; Scheuer, James

doi:10.1016/s0002-9149(83)80084-8

Cited by 29 publications

(5 citation statements)

References 27 publications

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“…In contrast to normal subjects, patients with AR had significantly higher RF than normal subjects, both at rest and during exercise (P < 0.0002) and the RF decreased during exercise (see Table I1 and Figure 2). This finding is consistent with previous reports of investigators using gated blood pool scanning or other independent techniques [ 12,13,. As a group, patients with AR increased their forward cardiac output mainly by an increase in heart rate and a slight (but insignificant) increase in forward stroke volume.…”

Section: Discuss I 0 Nsupporting

confidence: 92%

“…The RFs at rest and during exercise are summarized in Figure 2. As in previous radionuclide angiographic studies, a small RF was measured in normal subjects [1][2][3][4][5][6]12,13]. The RF did not change during exercise in normal subjects, but it decreased in patients with AR.…”

Section: Changes In Rfmentioning

confidence: 69%

“…Radionuclide ventriculography has been used to quantitate the severity of mitral and aortic regurgitation [1][2][3][4][5][6]12,13]. The principle is that the stroke volume of both ventricles should be equal in the absence of regurgitation.…”

Section: Discuss I 0 Nmentioning

confidence: 99%

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Regulation of cardiac output during upright exercise in patients with aortic regurgitation

Iskandrian

Hakki

Amenta

et al. 1984

Cathet. Cardiovasc. Diagn.

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The change in cardiac output during upright exercise in patients with aortic regurgitation (AR) is not well known. We measured left ventricular (LV) ejection fraction (EF) and volume, regurgitant fraction (RF), total cardiac output and forward cardiac output at rest, and peak upright exercise by means of radionuclide angiography in ten normal subjects and 15 patients with AR. In the normal subjects, there was no significant change in the end-diastolic volume but there was a significant decrease in the end-systolic volume (p = 0.0001) and a significant increase in EF (p = 0.0001). The increase in cardiac output during exercise was due to increases in both stroke volume and heart rate. In patients with AR, there was a significant decrease during exercise in RF (53 +/- 15% at rest, and 45 +/- 15% during exercise; p = 0.03), and in end-diastolic and end-systolic volume (p = 0.02, and p = 0.003, respectively). The EF increased during exercise (p = 0.003). The total stroke volume did not change (68 +/- 19 ml/m2 at rest, and 67 +/- 14 ml/m2 during exercise; p, NS). Thus, in patients with AR, individual changes in EF, RF, and volume are quite variable, but as a group a decrease in RF and an increase in heart rate contribute to the increase in forward flow. The total stroke volume may not increase during exercise, despite an increase in EF and a decrease in end-systolic volume because of a concomitant decrease in end-diastolic volume.

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Section: Discuss I 0 Nsupporting

confidence: 92%

Section: Changes In Rfmentioning

confidence: 69%

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Regulation of cardiac output during upright exercise in patients with aortic regurgitation

Iskandrian

Hakki

Amenta

et al. 1984

Cathet. Cardiovasc. Diagn.

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“…Radionuclide RF and semiquantitative aortogra phy demonstrated a good correlation (r = 0.72). Steingart et al [19] investigated 20 patients with pure AR and proved a high correlation of the radionuclide regur-…”

mentioning

confidence: 96%

Comparison of the Echo-Doppler- and Radionuclide Angiography- Derived Regurgitation Fraction in Isolated Chronic Aortic Regurgitation

Łastowiecka¹,

Rydlewska-Sadowska²,

Szumilak³

1994

Am J Noninvas Cardiol

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The regurgitation fraction (RF) despite dependence on many factors remains a valuable quantitative index in chronic aortic regurgitation (AR) assessment. In order to verify échocardiographie (Echo) estimation of this parameter a comparison with radionuclide ventriculography (RNY) values was done. 35 patients with chronic pure AR, 30 male, 5 female, mean age 35.5 ± 11.2 years (18-70 years) were examined. Echo RF was calculated according to the formula: RF = [(LVSY - RVSV)/LVSV] x 100, where LVSY and RVSV are the left and right ventricular stroke volumes; LVSV or RVSV = CSA x VFI, CSA = n (D/2)^2, where CSA = aortic or pulmonary cross-sectional area, D = aortic or pulmonary ring diameter, VFI = aortic or pulmonary velocity flow integral. On the following 0-22 days (mean 7 ± 5.12), gated equilibrium RNA with red blood cell-labelled 99mTc were done. All images were obtained with a small field of view Cardiac (Siemens) gamma camera with a Max Delta computer system. The study was done with a high-sensitivity colimator and contained 6 million counts (250 thousand/frame). RF calculation is based on the visual images of the end-systolic, enddiastolic counts and stroke volume of both ventricles. RNA RF was calculated according to the formula: RNA RF = [(LVEDc - LVESc) - (RVEDc - RVESc)/(LVEDc - LVESc)] x 100, where LVEDc, RVEDc, LVESc, RVESc are the left and right ventricular end diastolic and end systolic stroke counts. The mean Echo RF value was: 54.29 ± 12.44% (21-74%) and the meanRNVRF 52.06 ± 13.16% (17—80%). The correlation coefficient between the Echo and RNV RF was r = 0.68, p < 0.0001 (Pearson’s test). Excluding 9 patients with normal left ventricular internal diastolic dimension (LVIDD) (< 5.6 cm) increased the correlation coefficient up to r = 0.84, p < 0.0001. Using paired Student’s t test no significant difference between Echo and RNV RF was found. The mean difference of the RF values obtained with the two methods was -2.23 ± 10.17%. The highest discrepancy has occurred only in 4 patients with normal LVIDD (-30 to +25%).

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“…Chua et al (1997) (NEDER et al, 2003;WASSERMAN et al, 2004;POWERS et al, 2006 GOLDSCHLAGER et al, 1973;BONOW et al, 1980;BONOW et al, 1991 (BONOW et al, 1980). (BOUCHER et al, 1983;STEINGART et al, 1983;MASSIE et al, 1985;THOMPSON et al, 1985).…”

Section: O Teste De Esforço Cardiopulmonarmentioning

confidence: 99%

Estudo do comportamento hemodinâmico e variáveis metabólicas no teste de esforço cardiopulmonar e teste de caminhada de seis minutos em portadores de insuficiência aórtica crônica assintomáticos

Reis¹

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Radionuclide ventriculographic study of adaptations to exercise in aortic regurgitation

Cited by 29 publications

References 27 publications

Regulation of cardiac output during upright exercise in patients with aortic regurgitation

Regulation of cardiac output during upright exercise in patients with aortic regurgitation

Comparison of the Echo-Doppler- and Radionuclide Angiography- Derived Regurgitation Fraction in Isolated Chronic Aortic Regurgitation

Estudo do comportamento hemodinâmico e variáveis metabólicas no teste de esforço cardiopulmonar e teste de caminhada de seis minutos em portadores de insuficiência aórtica crônica assintomáticos

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