Radiopacity and mechanical properties of dental adhesives with strontium hydroxyapatite nanofillers

Carvalho, Elayne Valério; Paula, Diego Martins de; Neto, Davino M. Andrade; Costa, Luelc Souza da; Dias, Diego Felix; Feitosa, Victor Pinheiro; Fechine, Pierre Basílio Almeida

doi:10.1016/j.jmbbm.2019.103447

Cited by 36 publications

(18 citation statements)

References 54 publications

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“…It is worth to mention that hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2, HAp) is a natural construction material for bones and teeth and therefore is considered as biocompatible, bioactive and osteoconductive [5]. HAp has been used to fill up a wide range of bone defects in orthopedic and maxillofacial surgeries and dentistry [6][7][8]. It also has been widely used as a coating material for metallic prostheses to improve their biological properties [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial

Liu

Tan

2020

Journal of Asian Ceramic Societies

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Section: Introductionmentioning

confidence: 99%

Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial

Liu

Tan

2020

Journal of Asian Ceramic Societies

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“…Wu and co-workers [ 34 ] found that Bi 2 O 3 , the radiopacifier in calcium silicate bone cements, is harmful to cell proliferation, alkaline phosphatase (ALP) activity, and mineralization of human osteosarcoma MG63 cells. Recently, Sr-based radiopaque agents, especially the degradable species, have attracted more and more attention as they can simultaneously improve the radiopacity and bone repair capability of bone implants [ 30 , 31 , 32 , 34 , 35 , 36 , 37 ]. Various Sr-containing species such as SrCO 3 , SrX 2 , (X = F, Cl, Br, I), strontium ranelate (SrR), and strontium-substituted hydroxyapatite (SrHAp, maximum 100% Sr 2+ ) have been evaluated and show great X-ray absorption when they are added into bone implants [ 30 , 31 , 32 , 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Sr-based radiopaque agents, especially the degradable species, have attracted more and more attention as they can simultaneously improve the radiopacity and bone repair capability of bone implants [ 30 , 31 , 32 , 34 , 35 , 36 , 37 ]. Various Sr-containing species such as SrCO 3 , SrX 2 , (X = F, Cl, Br, I), strontium ranelate (SrR), and strontium-substituted hydroxyapatite (SrHAp, maximum 100% Sr 2+ ) have been evaluated and show great X-ray absorption when they are added into bone implants [ 30 , 31 , 32 , 34 , 35 , 36 , 37 ]. Furthermore, most of them are soluble (SrCl 2 and SrBr 2 ) or have relatively high solubility (SrCO 3 , SrHAp, and SrR) and can continuously release Sr 2+ , which is able to enhance osteoblast activity and inhibit osteoclast activity [ 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Fabrication of MgNH4PO4·H2O/SrHPO4 Porous Composite Scaffolds with Improved Radiopacity via 3D Printing Process

Cao

Wang

et al. 2021

Biomedicines

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Although bone repair scaffolds are required to possess high radiopacity to be distinguished from natural bone tissues in clinical applications, the intrinsic radiopacity of them is usually insufficient. For improving the radiopacity, combining X-ray contrast agents with bone repair scaffolds is an effective method. In the present research, MgNH4PO4·H2O/SrHPO4 3D porous composite scaffolds with improved radiopacity were fabricated via the 3D printing technique. Here, SrHPO4 was firstly used as a radiopaque agent to improve the radiopacity of magnesium phosphate scaffolds. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS) were used to characterize the phases, morphologies, and element compositions of the 3D porous composite scaffolds. The radiography image showed that greater SrHPO4 contents corresponded to higher radiopacity. When the SrHPO4 content reached 9.34%, the radiopacity of the composite scaffolds was equal to that of a 6.8 mm Al ladder. The porosity and in vitro degradation of the porous composite scaffolds were studied in detail. The results show that magnesium phosphate scaffolds with various Sr contents could sustainably degrade and release the Mg, Sr, and P elements during the experiment period of 28 days. In addition, the cytotoxicity on MC3T3-E1 osteoblast precursor cells was evaluated, and the results show that the porous composite scaffolds with a SrHPO4 content of 9.34% possessed superior cytocompatibility compared to that of the pure MgNH4PO4·H2O scaffolds when the extract concentration was 0.1 g/mL. Cell adhesion experiments showed that all of the scaffolds could support MC3T3-E1 cellular attachment well. This research indicates that MgNH4PO4·H2O/SrHPO4 porous composite scaffolds have potential applications in the bone repair fields.

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“…The low dissolution of HA in the human body after implantation and fast release of calcium and phosphate ions from β-tricalcium phosphate when exposed to physiological uids limit its use in clinical applications [15]. Signi cant research has been carried out for both cationic and anionic hydroxyapatite substitutions [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…Hydroxyapatite and silica have been used as llers for dental applications [20][21][22]12,17,23]. Even hydroxyapatite based composite resins are bioinert with hardness like natural teeth, its exhibit lower strength and higher failure rates.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silica/Hydroxyapatite Nanocomposite by Mechanochemical Method

Hannora

Mostafa

2021

Preprint

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Biocompatibility of Silica makes it a suitable material for biomedical applications. The main components of teeth and bones are calcium phosphate (CP). Hydroxyapatite (HA) is expected to be used in different fields not only in biomedical applications but also in agriculture as a fertilizer and pollution treatment. Various substitutions in the apatite lattice play a significant role in its properties. In the present work, Silica-50, 40, 30 and 25 mol.% Hydroxyapatite nanocomposites were prepared successfully by mechanochemical processing method. X-ray diffraction (XRD) and Fourier Transform Infrared (FT-IR) indicated that silica stimulates the HA decomposition to β-tricalcium phosphate (β-TCP). XRD of heat-treated compacted sample at 1200oC confirmed β-TCP and calcium phosphate silicate phases formation. Mechanical properties decreased with decreasing HA content. Electrochemical impedance spectroscopy (EIS) results revealed that pure HA possess the highest resistivity to corrosion, while the silica/HA samples showed lower corrosion resistance. The polarization resistance increases with HA content.

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Radiopacity and mechanical properties of dental adhesives with strontium hydroxyapatite nanofillers

Cited by 36 publications

References 54 publications

Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial

Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial

Rapid Fabrication of MgNH4PO4·H2O/SrHPO4 Porous Composite Scaffolds with Improved Radiopacity via 3D Printing Process

Synthesis of Silica/Hydroxyapatite Nanocomposite by Mechanochemical Method

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