Radiopaque Hemocompatible Ruminant-Sourced Gut Material with Antimicrobial Physiognomies for Biomedical Applications in Diabetics

Abstract

This study comprises the fabrication of a radiopaque gut material with its mechanical properties conforming to the US Pharmacopeia guidelines giving an antimicrobial advantage for suture application, especially in conditions such as diabetes mellitus, which has a high wound infection rate. Schiff base cross-linking iodination of the material is evinced by the spectroscopic studies, and antimicrobial properties owing to released iodine are evinced through in vitro studies. Modified gut sutures demonstrated favorable physicomechanical features such as appropriate tensile strength (440 ± 20 MPa) and knot strength (270 ± 20) alongside a mean radiopacity value of 139.0 ± 10 in comparison with that of the femoral shaft with 160 ± 10. The diabetic model showed absence of clinical signs of infection, supported by wound swab culture and the absence of necrosis in histology. Hemocompatibility studies evinced the absence of contact platelet activation and hemolysis alongside the customary coagulation response. These promising results highlight the stimulating potential of the process in the development of biomedical applications, necessitating persistent studies for its evidence-based applicability, particularly in diabetic patients.

Cross-Linked Chitosan as an Eco-Friendly Binder for High-Performance Wood-Based Fiberboard

“…Compared with F-DHF-CS, DHF cross-linked CS has a more obvious characteristic peak at 399.1 eV. Compared with F-W, F-DHF-CS possessed a more obvious characteristic peak at 399.1 eV which was corresponded to the N1s [27], indicating that wood fiber surface was successfully covered by the nitrogen-containing crosslinked CS.…”

Silk-based intelligent fibers and textiles: structures, properties, and applications

“…After degumming treatment to remove sericin, the resulting solution can be used to prepare regenerated silk protein fibers by various processing methods (electrostatic spinning, 22,23 wet spinning, 24,25 dry spinning, 19 direct writing 26 and microfluidic spinning). 27,28 However, the mechanical strength of regenerated silk fibers is lower than that of the original silk, which can be optimized by optimizing the preparation process, improving the spinning conditions, and introducing cross-linking 29 agents to enhance intermolecular binding. At the same time, the mechanical properties of the fibers can also be improved to a certain extent by adding nano conductive materials, such as carbon nanomaterials, 30 conductive polymers 31 and metal nanoparticles, 32–34 through rational selection and design.…”