Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

Tian, Li; Lu, Linfeng; Feng, James J.; Melancon, Marites P.

doi:10.1016/j.apsb.2018.03.002

Cited by 34 publications

(24 citation statements)

References 98 publications

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“…Atherosclerosis (AS), a leading cause of death worldwide, is a lipid-driven inflammatory disease 1 , 2 . AS is characterized by plaque buildup at the arterial subendothelial space (intima) due to the accumulation of diseased cells including monocytes, macrophages, endothelial cells, smooth muscle cells, neutrophils, lipids, and extracellular matrix components 3 , 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

Teng

Lin

Huang

et al. 2020

Acta Pharmaceutica Sinica B

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Atherosclerosis (AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein, targeted codelivery of anti-miR 155 and anti-inflammatory baicalein is exploited to polarize macrophages toward M2 phenotype, inhibit inflammation and treat AS. The codelivery system consists of a carrier-free strategy (drug-delivering-drug, DDD), fabricated by loading anti-miR155 on baicalein nanocrystals, named as baicalein nanorods (BNRs), followed by sialic acid coating to target macrophages. The codelivery system, with a diameter of 150 nm, enables efficient intracellular delivery of anti-miR155 and polarizes M1 to M2, while markedly lowers the level of inflammatory factors in vitro and in vivo . In particular, intracellular fate assay reveals that the codelivery system allows for sustained drug release over time after internalization. Moreover, due to prolonged blood circulation and improved accumulation at the AS plaque, the codelivery system significantly alleviates AS in animal model by increasing the artery lumen diameter, reducing blood pressure, promoting M2 polarization, inhibiting secretion of inflammatory factors and decreasing blood lipids. Taken together, the codelivery could potentially be used to treat vascular inflammation.

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Section: Introductionmentioning

confidence: 99%

Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

Teng

Lin

Huang

et al. 2020

Acta Pharmaceutica Sinica B

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“…Besides, although polymeric devices can be detected by ultrasound technique after implantation in vivo, 29,30 computed tomography (CT) can present the size, shape, and composition of implanted device, which is important for postoperative analysis. 31,32 Thus, the development of radiopaque resorbable materials still remains as an urgent need for clinical use.…”

Section: Resultsmentioning

confidence: 99%

Iodinated poly(p-dioxanone) as a facile platform for X-ray imaging of resorbable implantable medical devices

Zhao

Xue

et al. 2020

J Biomater Appl

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Currently, implantable fibrous medical devices still suffer from invisibility under current clinical imaging techniques. To address this problem, 2, 3, 5-triiodobenzoic acid (TIBA) was recruited as a contrast agent, and then a set of iodinated poly( p-dioxanone) (PPDO) fibers was fabricated via melt-spinning hybrid blends of PPDO with TIBA (PPDO/TIBA). The impact of TIBA content on the rheological behavior of blends was evaluated firstly. The physical, chemical, and thermal properties of PPDO/TIBA fibers were investigated accordingly by SEM, FTIR, DSC, and TGA. Moreover, the radiopaque property of PPDO/TIBA hybrid fibers as a potential radio-opacifying platform for medical devices was verified in vitro and in vivo. Finally, the accumulated release results of the hybrid fibers during in vitro degradation indicate the continual X-ray visibility of the hybrid fibers maintains for 22 days. This intriguing iodinated platform may pave the way for constructing fibrous materials with in-situ X-ray tracking property.

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“…In other words, we could further decrease the radiopaque agent content in our formulation and hence viscosity, without significantly altering the fluoroscopic visibility of the liquid precursor. Radiopaque nanoparticles might also improve injectability to an even greater extent (Tian et al, 2018) and allow a higher percentage of polymer, thereby potentially shortening the photosolidification process to a minute or less. It is known that iodinated contrast agents are subject to leak to the surrounding environment (Lei et al, 2016), as it was demonstrated for our hydrogel over the following days due to the immersion process ( Figure 6B).…”

Section: Discussionmentioning

confidence: 99%

In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial Aneurysms

Poupart

Schmocker

Conti

et al. 2020

Front. Bioeng. Biotechnol.

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Intracranial aneurysms are increasingly being treated with endovascular therapy, namely coil embolization. Despite being minimally invasive, partial occlusion and recurrence are more frequent compared to open surgical clipping. Therefore, an alternative treatment is needed, ideally combining minimal invasiveness and long-term efficiency. Herein, we propose such an alternative treatment based on an injectable, radiopaque and photopolymerizable polyethylene glycol dimethacrylate hydrogel. The rheological measurements demonstrated a viscosity of 4.86 ± 1.70 mPa.s, which was significantly lower than contrast agent currently used in endovascular treatment (p = 0.42), allowing the hydrogel to be injected through 430 µm inner diameter microcatheters. Photorheology revealed fast hydrogel solidification in 8 min due to the use of a new visible photoinitiator. The addition of an iodinated contrast agent in the precursor contributed to the visibility of the precursor injection under fluoroscopy. Using a customized light-conducting microcatheter and illumination module, the hydrogel was implanted in an in vitro silicone aneurysm model. Specifically, in situ fast and controllable injection and photopolymerization of the developed hydrogel is shown to be feasible in this work. Finally, the precursor and the polymerized hydrogel exhibit no toxicity for the endothelial cells. Photopolymerizable hydrogels are expected to be promising candidates for future intracranial aneurysm treatments.

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Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

Cited by 34 publications

References 98 publications

Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease

Iodinated poly(p-dioxanone) as a facile platform for X-ray imaging of resorbable implantable medical devices

In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial Aneurysms

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