Radioprotection by superoxide dismutase of macrophage progenitor cells from mouse bone marrow

Petkau, A.; Chelack, W.S.

doi:10.1016/0006-291x(84)90886-6

Cited by 32 publications

(8 citation statements)

References 10 publications

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“…They are often selectively beneficial for normal tissues, due to differences in either uptake or target sensitivity between normal and cancer cells [33,34]. SOD inhibits RT-induced changes in a number of biological end points, including enzyme activity, membrane integrity, DNA damage, cell transformation and cell and organism survival [35][36][37]. A series of studies by our group [17,18] and Epperly et.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Administration of a Small Molecular Weight Catalytic Metalloporphyrin Antioxidant AEOL 10150 Protects Lungs From Radiation-Induced Injury

Rabbani

Batinić‐Haberle

Poulton

et al. 2005

International Journal of Radiation Oncology*Biology*Physics

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Purpose-To determine whether administration of a catalytic antioxidant, Mn(III) tetrakis(N,N′-diethylimidazolium-2-yl) porphyrin, AEOL 10150, with SOD mimetic properties reduces the severity of radiation-induced injury to the lung from single dose irradiation (RT) of 28 Gy.Materials/Methods-Animals were randomly divided into four different dose groups (0, 1, 10 and 30 mg/kg/day of AEOL 10150), receiving either short (1 week) or long-term (10 weeks) drug administration via osmotic pumps. Animals received single dose irradiation (RT) of 28 Gy to the right hemithorax. Breathing rates, body weights, blood samples, histopathology and immunohistochemistry were used to assess lung damage.Results-There was no significant difference in any of the study endpoints between the irradiated controls and the 3 groups receiving RT and short-term administration of AEOL 10150. For the long term administration functional determinants of lung damage 20 weeks post radiation were significantly worse for RT+PBS and RT+1mg/kg/day of AEOL 10150 as compared to the irradiated groups treated with higher doses of AEOL 10150 (10 or 30mg/kg/day), Lung histology at 20 weeks revealed a significant decrease in structural damage and collagen deposition in animals receiving 10 or 30mg/kg/day after radiation in comparison to RT+PBS and 1mg/kg/day groups. Immunohistochemistry demonstrated a significant reduction in macrophage accumulation, oxidative stress and hypoxia in animals receiving AEOL 10150 (10 or 30mg/kg/day) after lung irradiation compared to RT+PBS and 1mg/kg/day groups. Conclusion-The chronic administration of novel catalytic antioxidant, AEOL 10150, demonstrates a significant protective effect from radiation-induced lung injury. AEOL 10150 has its primary impact on the cascade of events following irradiation and adding drug prior to irradiation and its short-term administration have no significant additional benefits.

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Section: Discussionmentioning

confidence: 99%

Long-Term Administration of a Small Molecular Weight Catalytic Metalloporphyrin Antioxidant AEOL 10150 Protects Lungs From Radiation-Induced Injury

Rabbani

Batinić‐Haberle

Poulton

et al. 2005

International Journal of Radiation Oncology*Biology*Physics

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“…Bugün artık bu soruya olumlu yanıtlar verebilmekteyiz : Petkau ve arkadaşlarının ve Breimer'in yaptıkları çalışmaların sonuçları radyasyonla indüklenen karsinogenezizin, reaktif oksijen metabolit harabiyeti ile başlatıldığını düşündürmektedir (6,34,35). Selenyum ya da vitamin E'mn diyette kronik eksikliği sonucu görülen belirtilerin de reaktif oksijen metabolitleri tarafından açığa çıkarıldığı ileri sürülmektedir (26,29).…”

Section: Ozunclassified

Reakti̇f Oksi̇jen Metaboli̇tleri̇ne Fi̇zyopatoloji̇k Yaklaşim

Kavas¹

1994

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Reaktif oksijen metabolitleri yetmişli yıllardan itibaren yoğun ilgi çekmeye başlamıştır. İlginin başlangıcı 1968 lerde superoksit dismutaz adı verilen, kısaca «SOD» olarak gösterilen ve superoksit radikalinin ortamdan temizlenmesini sağlayan bir enzimin tanınmasını izleyen döneme rastlar.Oksijen molekülüne bir fazla elektronun eklenmesi sonucu oluşan bir reaktif oksijen metaboliti yani superoksit radikalinin (02) (Reaksiyon 1) ortadan kaldırılması, superoksit dismutaz enziminin katalize ettiği dismutasyon reaksiyonu ile gerçekleşir. Dismutasyon reaksiyonu sırasında, bir superoksit radikali oksijene yükseltgenirken bir başka superoksit radikali ise hidrojen peroksite (H202) indirgenir (Reaksiyon 2).02 + e-> 0"2 (Reaksiyon 1) SOD 0~2 + 0-2 + 2H+ * H202 -I-02 (Reaksiyon 2) Bu derlemede, aralarında superoksit radikalinin de bulunduğu reaktif oksijen metabolitlerinin insan organizmasında üretimleri ve bazı toksik etkileri özetlenerek fizyopatolojik açıdan giderek artan önem-leri yeni literatür bilgilerinin ışığında gözden geçirilmeye çalışılmış-tır.

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“…A group of naturally occurring low molecular weight antioxidants and ROS removing enzymes (superoxide dismutase [SOD], catalase, glutathione peroxidase [GPx], and ascorbate peroxidase [APOx]) protect cells from radiation-induced ROS mediated cell death (Petkau and Chelack 1984, Rose 1990, Duff y et al 1998, Chen et al 2002, Epperly et al 2002, 2009, Neal et al 2003, Weiss and Landauer 2003. Activity and expression of antioxidant enzymes such as superoxide dismutases (mitochondrial manganese-SOD [Mn-SOD] and cytoplasmic/nuclear copper-Zinc-SOD [Cu-Zn-SOD]), catalase and glutathione peroxidase (GPx) are known to modulate cellular radiosensitivity (Fridovich 1975, Bowler et al 1992, Steven et al 1997, Mat é s 2000.…”

Section: Introductionmentioning

confidence: 99%

Radioresistant Sf9 insect cells display efficient antioxidant defence against high dose γ-radiation

Suman

Khan

Zarin

et al. 2015

International Journal of Radiation Biology

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Radioprotection by superoxide dismutase of macrophage progenitor cells from mouse bone marrow

Cited by 32 publications

References 10 publications

Long-Term Administration of a Small Molecular Weight Catalytic Metalloporphyrin Antioxidant AEOL 10150 Protects Lungs From Radiation-Induced Injury

Long-Term Administration of a Small Molecular Weight Catalytic Metalloporphyrin Antioxidant AEOL 10150 Protects Lungs From Radiation-Induced Injury

Reakti̇f Oksi̇jen Metaboli̇tleri̇ne Fi̇zyopatoloji̇k Yaklaşim

Radioresistant Sf9 insect cells display efficient antioxidant defence against high dose γ-radiation

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