Radioprotective activity of metalladithioacetals derived from N‐substituted naphthylethylimidazoline

Abstract

A number of organosilicon and organogermanium derivatives of N-substituted 2-[1-(1-naphthyl)-ethyl]-2-imidazoline have been reported and the toxicity of these compounds has been determined in mice. In this paper we report the evaluation of the radioprotective activity of new sila-and germadithioacetals derived from N-substituted 2-[1-(1-naphthyl)ethyl]-2-imidazoline.

Synthesis and Radioprotective Effects of New Phosphorothioates Derived From Naphthylmethylimidazoline and Naphthylethylimidazoline

“…SCHEME 4 Structures of phosphorus derivatives obtained (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). In order to determine the LD 50 of irradiation, we had to draw the straight line of mortality as a function of the decimal logarithm of the dose ( Figure 1).…”

“…The spectroscopic and physicochemical data of all these compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) are reported in the following sections. …”

“…Moreover, the association of WR-2721 with naphthylmethylimidazoline produces a synergy of action for injected amounts to which no toxicity is observed for the two components. 14 In order to corroborate this idea, we have described the synthesis and radioprotection studies of new phosphorothioate derived from N-substituted naphthylmethylimidazoline and naphthylethylimidazoline.…”

Nouveaux phosphorothioates dérivés de la naphthylméthylimidazoline et de la naphthyléthylimidazoline : application en radioprotection chimique

“…Article published by EDP Sciences and available at http://www.edpsciences.org/radiopro or http://dx.doi.org/10.1051/radiopro:2004016 développés par notre laboratoire (Célariès et al, 2001a(Célariès et al, , 2001b(Célariès et al, , 2003a(Célariès et al, , 2003bFatôme et al, 1984Fatôme et al, , 1988Rima et al, 1991Rima et al, , 1993Rima et al, , 1994Rima et al, , 1996Rima et al, , 1997Rima et al, , 1998Rima et al, , 1999aRima et al, , 1999bSatgé et al, 1982Satgé et al, , 1989, à savoir : -la libération in vivo, retardée ou prolongée, d'une ou plusieurs substances organiques possédant des propriétés radio-protectrices (aminothiols) ; -une modification fondamentale des propriétés chimiques ou biologiques de ces dérivés de base.…”