Radioprotective Effect of Nigella Sativa Oil on Heart Tissues of Rats Exposed to Irradition

Abstract

Radiotherapy is an important treatment method for a wide variety of malignancies. Ionizing radiation (IR) is known to generate free radicals in irradiated tissues.¹ Mammalian cells have both enzymatic and non-enzymatic cleansing systems to remove reactive oxygen species (ROS) and reactive nitrogen species (RNS), respectively.² An imbalance favoring the prooxidants and disfavoring the antioxidants, potentially leading to damage, has been called "oxidative stress."³ Efforts to reduce the toxicity of irradiation to normal tissues, organs, and cells have led to the investigation of cytoprotective agents.⁴ Many dietary components may have either direct antioxidant activity, such as flavonoids, melatonin, nigella sativa oil (NSO), and thymoquinone(TQ),⁵ or indirect antioxidant activity, such as zinc,⁶ manganese, and selenium.⁷ NSO is commonly known as 'black seed' and has strong antioxidant properties against oxidative damage.⁸ Many studies have reported that it has various pharmacological properties, including

Will Nigella sativa oil protect parotid glands of rats against cranium gamma irradiation? Histological and immunohistochemical evaluation

“…Mouket et al [ 34 ] demonstrated the radio-protective effect of NSO on salivary glands exposed to total cranial irradiation in terms of a significant reduction in oxidative stress markers and strong antioxidant effects. Additionally, the radio-protective effect of NSO on the irradiated heart was confirmed by Kaplan et al [ 35 ], where NSO significantly decreased TOS and OSI levels in the heart tissue, while TAS levels significantly increased. Moreover, Shahzad et al [ 36 ] found that NSO administration reduced inflammation and collagen deposition in the lungs of ovalbumin exposed rats with a marked reduction in transforming growth factor beta mRNA expression.…”

Will Nigella sativa oil protect parotid glands of rats against cranium gamma irradiation? Histological and immunohistochemical evaluation

“…Mouket et al [34] demonstrated the radio-protective effect of NSO on salivary glands exposed to total cranial irradiation in terms of a signi cant reduction in oxidative stress markers and strong antioxidant effects. Additionally, the radio-protective effect of NSO on the irradiated heart was con rmed by Kaplan et al [35] , where NSO signi cantly decreased TOS and OSI levels in the heart tissue, while TAS levels signi cantly increased. Moreover, Shahzad et al [36] found that NSO administration reduced in ammation and collagen deposition in the lungs of ovalbumin exposed rats with a marked reduction in transforming growth factor beta mRNA expression.…”