Radioprotective effects of black seed (<i>Nigella sativa</i>) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats

Assayed, Mohamed Ezzat

doi:10.3109/08923970903307552

Cited by 79 publications

(65 citation statements)

References 58 publications

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“…Indeed, it is used for the treatment of asthma, bronchitis, cough, fever and headaches (8). Previous studies have demonstrated that NS seed has numerous therapeutic activities, such as anti-inflammatory (9), antioxidant (5,10), immune-modulatory (11), cardioprotective (12,13) and hepatoprotective effects (14). However, the effects of NS seed on the fatigue following exercise have not yet been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Rahman

Yang

Kim³

et al. 2017

Biomedical Reports

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Abstract. In previous studies, Nigella sativa (NS) has been studied due to its various physiological and pharmacological activities. However, evidence on the effects of NS on physical fatigue following exhaustive swimming remains limited. In the present study, the authors evaluated the potential beneficial effects of NS against the fatigue activity following exhaustive swimming. Rats were orally administered with NS extract (2 g/kg/day) for 21 days, and the anti-fatigue effect was assessed by exhaustive swimming exercise. The presented results indicated that pre-treatment of NS extract significantly increased the time to exhaustion. In hemodynamic parameters, NS extract increased blood pO 2 and O 2sat , but decreased pCO 2 . For underlying mechanisms, NS extract protected depletion of energy, indicated by increased levels of blood pH, glucose and tissue glycogen contents, and decreased levels of blood lactate, tissue lactic dehydrogenase and creatine kinase, when the NS extract was pre-treated. In addition, the NS extract inhibited oxidative stress following exhaustive swimming, as reflected by the results of increased levels of superoxide dismutase and redox ratio, and decreased the level of malondialdehyde when the NS extract was pre-treated. Collectively, the present study demonstrated that NS extract has an anti-fatigue activity against exhaustive swimming by energy restoration and oxidative-stress defense.

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Section: Introductionmentioning

confidence: 99%

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Rahman

Yang

Kim³

et al. 2017

Biomedical Reports

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“…TQ intraperiotoneally was found to be almost 90% preventive and 50% curative in chronic relapsing EAE due to its antioxidant effect [76] . N. sativa oil is a promising natural radioprotective agent against immunosuppressive and oxidative effects of ionizing radiation [6] . Daily oral administration of N. sativa oil to rats before whole body gamma irradiation resulted in significant reversal of reduction of hemolysin antibodies titers.Potential immunomodulation effect of the extract of N. sativa on ovalbumin sensitized guinea pigs was evaluated.…”

Section: Immunomodulatory Activitymentioning

confidence: 99%

“…The black seed oil and TQ by intraperitonial injection were found to shown protective effects on lipid peroxidation process during ischemia-reperfusion injury (IRI) in rat hippocampus [42] . Treating broiler chicks with black seed for 6 weeks prevented the liver from oxidative stress by increasing the activities of enzymes such as myeloperoxidase, glutathione-S-transferase, CAT, adenosine deaminase, myeloperoxidaseand bydecreasing hepatic lipid peroxidation [43] . The crude methanolic extract of black cumin seed cake was found to shown with significant antioxidant properties under in vitro systems [44] .The modulatory effect of TQ on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine-(DMH-) induced colon carcinogenesis after initiation in male Wistar rats was investigated and The TQ pre-treatment restored the increased level of malondialdehyde and conjugated diene levels, and an augmentation of enzyme activities like CAT, glutathione peroxidase, and SOD activities due to exposure to DMH.…”

Section: Antioxidant Activitymentioning

confidence: 99%

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,117

796

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“…The seeds of NS are widely used in the treatment of numerous diseases such as bronchitis, asthma, diarrhea, rheumatism, and skin disorders. In addition to that, many literatures reported that NS was used as liver tonic, digestive, antidiarrheal, appetite stimulant, emmenagogue, and supportive of immune system [11][12][13]. Most of the therapeutic properties of this plant are due to the presence of thymoquinone (TQ), which is a major active chemical component of the essential oil.…”

Section: Introdctionmentioning

confidence: 99%

Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

Osman

2017

Asian J Pharm Clin Res

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Osteoporosis is the most common reason for a broken bone among the elderly. Several experimental studies have been reported that Nigella sativa (NS) and/or its major component thymoquinone (TQ) have good effects on osteoporosis and bone healing. We conducted this systematic review to evaluate these relevant studies to prove whether NS and/or TQ has potential effect on osteoporosis and can stop pathogenesis of this disease or this matter still just a fiction. A search on published studies was done using databases including Scopus, PubMed, Google Scholar, Web of Science, and CINAHIL. Terms searched included "Nigella sativa, black seed, TQ, osteoporosis, bone healing." Initially, 213 articles were extracted. After reviewing their titles and abstracts, 124 articles (Medline, 43; Scopus, 67; EBSCO, 14) were retrieved for further evaluation. However, after excluding the clinical trial studies, human reviews, removal of abstracts and unrelated studies, seven studies were considered finally as eligible for our review. Finally, seven studies were considered eligible for our review. The total number of animals used was 220 (150 rats and 70 rabbits) from different experimental study. Based on the results of this systematic review, we conclude that NS or TQ extract therapy for osteoporosis cannot be recommended yet and these data will not suffice to exclude the beneficial effects of NS on bone turnover reliably. Therefore, more studies are required to explore the specific cellular and molecular targets of NS or TQ using animal osteoporosis models. Once the anti-osteoporotic effectiveness of NS or TQ will be established, human studies can be carried out.

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Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats

Abstract: Our results strongly recommend Nigella sativa oil as a promising natural radioprotective agent against immunosuppressive and oxidative effects of ionizing radiation.

Cited by 79 publications

References 58 publications

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

A review on therapeutic potential of Nigella sativa: A miracle herb

Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

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