Radioprotective Effects of Ginsan, an Immunomodulator

Song, Jie‐Young; Han, Seon-Kyu; Bae, Kang-Gyu; Lim, Dae‐Seog; Son, Soo-Jung; Jung, In‐Ha; Yi, Seh-Yoon; Yun, Yeon-Sook

doi:10.1667/0033-7587(2003)159[0768:reogai]2.0.co;2

Cited by 96 publications

(71 citation statements)

References 29 publications

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“…P. ginseng is a well-known medicinal herb containing multiple bioactive constituents that is extensively used in China and Korea. The plant has a variety of beneficial activities including antitumor, antioxidant, anti-aging, antifungal, anti-inflammatory and neuroprotective properties (85)(86)(87)(88)(89)(90). Ginseng contains various types of ginsenosides (major active components), kaempferol, caffeic acids, acidic polysaccharides and palmitic acids in its stem, leaves and roots.…”

Section: Zingiber Officinalementioning

confidence: 99%

“…Ginseng contains various types of ginsenosides (major active components), kaempferol, caffeic acids, acidic polysaccharides and palmitic acids in its stem, leaves and roots. The majority of the evidence for the radioprotective properties of ginseng has been accumulated over the last several decades (90)(91)(92)(93). For example, the administration of ginseng extracts resulted in suppression of radiation-induced inflammatory response through inhibition of cyclooxygenase-2 overexpression, as well as recovery of spleen and thymus damage induced by radiation exposure in mouse models (94).…”

Section: Zingiber Officinalementioning

confidence: 99%

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Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

et al. 2017

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Abstract. The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation-induced damage. The potential for antioxidants to decrease normal tissue damage induced by radiation has been investigated in animal models for a number of decades. In attempts for radioprotection, certain synthetic chemicals are suggested as antioxidants and normal tissue protectors against radiation-induced damage, but they have exhibited limitations in pharmacological application due to undesirable effects and high toxicities at clinical doses. The present review focuses on the radioprotective efficacy of traditional oriental medicines with the advantage of low toxicity at pharmacological doses and how such treatments may influence various harmful effects induced by radiation in vitro and in vivo. In addition, medicinal plants and their active constituents with biological activities that may be associated with alleviation of radiation-induced damage through antioxidant, anti-inflammatory, wound healing and immunostimulatory properties are discussed.

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Section: Zingiber Officinalementioning

confidence: 99%

Section: Zingiber Officinalementioning

confidence: 99%

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

et al. 2017

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“…Ginseng not only has good anti-radiation and anticancer effects but can also inhibit cell mutation and apoptosis (Song et al, 2003;Zhang et al, 2013;Zhu et al, 2014). Scutellaria has anti-radiation, anticancer, free radical scavenging, and antioxidant effects (Mei et al, 2004;Lei, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of Shenqin biochemical extract on hypoxia-inducible factor-1α expression in ultraviolet B-irradiated HaCaT cells

Chen¹,

Bai²,

Y³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Hypoxia-inducible factor-1α (HIF-1α) is considered the main transcriptional regulator of the hypoxia-specific cellular and developmental response. This study was performed to investigate the effect of Shenqin biochemical extract (SQBE) on HIF-1α expression in ultraviolet B (UVB)-irradiated HaCaT cells and the possible action mechanisms of SQBE against UVB-induced skin cancer. HaCaT cells in logarithmic growth phase were seeded in Dulbecco's modified Eagle's medium with 10% fetal bovine serum, and conventionally cultured at 37°C with 5% CO 2 . Cells were divided into control group (administered the same amounts of dimethyl sulfoxide), SQBE1 group (12.5 μg/mL SQBE), SQBE2 group (25.0 μg/mL SQBE), and SQBE3 group (50.0 μg/mL SQBE). Four hours post administration, the control and treatment groups were irradiated with UVB (0, 20, 40, and 60 mJ/cm 2 ). After 24 h, cell survival rate was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Expression levels of HIF-1α mRNA and protein were detected by polymerase chain reaction and western blotting, respectively. SQBE-treated, UVB-irradiated cells had improved survival rates. This increase was most significant in SQBE3 group (P < 0.01), which also had effectively reduced expression of intracellular HIF-1α mRNA and protein. Hence, SQBE had a protective effect on UVB-irradiated HaCaT cells and inhibited the UVB irradiation-induced expression of HIF-1α. This indicates that SQBE could prevent the occurrence of UVB radiation-induced skin cancer.

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“…People have isolated a series of active ingredients from natural anti-radiation substances, such as polysaccharides (Subramanian et al, 2002;Song et al, 2003;Il´in et al, 2004;Fan et al, 2005) (Devi et al, 1998;Liu et al, 2002;Zielonka et al, 2003;, polyphenols (Hibasami et al, 2000;Lv et al, 2004), saponins (Chen et al, 1999;Kim et al, 2001;Li et al, 2001;Kuinar et al, 2003), alkaloids (Liang et al, 2002;Makarchenko and Utkina 2006 ), and peptides compounds (Zhu and Zhong 2004;Yang 2007), etc. Rosa roxburghii Tratt (Figure 1) is the fruit of jiao-si flower or unicuspid jiao-si flower from rosaceae, which was firstly recorded in the "ben-cao-gang-mu-shi-yi".…”

Section: Introductionmentioning

confidence: 99%

Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors

Zhang²,

Cai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). Materials and Methods: The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. Results: The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of 30 µg/mL. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. Conclusions: Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.

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Radioprotective Effects of Ginsan, an Immunomodulator

Cited by 96 publications

References 29 publications

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

Effect of Shenqin biochemical extract on hypoxia-inducible factor-1α expression in ultraviolet B-irradiated HaCaT cells

Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors

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