Radioprotective efficacy of dieckol against gamma radiation-induced cellular damage in hepatocyte cells

Sadeeshkumar, Velayutham; Arul, D.; Aishwarya, Thiyagarajan; Jayaram, Prithi; Ravichandran, S.; Ganeshamurthy, Raghunathan

doi:10.1007/s00210-019-01652-z

Cited by 8 publications

(6 citation statements)

References 54 publications

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“…Lastly, Xu and co-workers proved that 4 could be used to treat pancreatic cancer since it increased the expression of proapoptotic protein (Bax) and decreased antiapoptotic Bcl2 protein as well as cyclin D1, whose overexpression is often related to chemoresistance [109]. Finally, deickol (4) was found to provide the protection from gamma radiation and consequent damage, both in vitro and in vivo [110,111].…”

Section: Phlorotanninsmentioning

confidence: 99%

“…and PANC-1 (pancreatic cancer) cells [105,109] Protective and chemopreventing effects against hepatocellular carcinoma (HCC) in rats via upregulation of VEGF, MMP-2/9, PCNA and COX-2 [106,107] Anti-migratory and apoptotic activity in A549 cells associated with inhibition of Pi3K/AKT/mTOR signalling pathways and activation of tumor-suppressor, E-cadherin [108] Protection from gamma radiation and consequent damage, both in vitro and in vivo [110,111] Diphlorethohydroxycarmalol 5…”

Section: Eckolmentioning

confidence: 99%

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Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

et al. 2022

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Since the middle of the last century, marine organisms have been identified as producers of chemically and biologically diverse secondary metabolites which have exerted various biological activities including anticancer, anti-inflammatory, antioxidant, antimicrobial, antifouling and others. This review primarily focuses on the marine phenolic compounds and their derivatives with potent anticancer activity, isolated and/or modified in the last decade. Reports on the elucidation of their structures as well as biosynthetic studies and total synthesis are also covered. Presented phenolic compounds inhibited cancer cells proliferation or migration, at sub-micromolar or nanomolar concentrations (lamellarins D (37), M (38), K (39), aspergiolide B (41), fradimycin B (62), makulavamine J (66), mayamycin (69), N-acetyl-N-demethylmayamycin (70) or norhierridin B (75)). In addition, they exhibited anticancer properties by a diverse biological mechanism including induction of apoptosis or inhibition of cell migration and invasive potential. Finally, phlorotannins 1–7 and bromophenols 12–29 represent the most researched phenolic compounds, of which the former are recognized as protective agents against UVB or gamma radiation-induced skin damages. Finally, phenolic metabolites were assorted into six main classes: phlorotannins, bromophenols, flavonoids, coumarins, terpenophenolics, quinones and hydroquinones. The derivatives that could not be attributed to any of the above-mentioned classes were grouped in a separate class named miscellaneous compounds.

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Section: Phlorotanninsmentioning

confidence: 99%

Section: Eckolmentioning

confidence: 99%

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

et al. 2022

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“…From the results, it has been confirmed that eckol pretreatment efficiently scavenged ROS in gamma-irradiated V79-4 cells, protecting against DNA damage by decreasing oxidative damage. Sadeeshkumar et al [64] tested the radioprotective activity of dieckol in γ radiation-induced rat primary hepatocytes. Rat treated with dieckol showed reduced γ radiation-induced toxicity and enhanced the antioxidant activity, as well as decreased DNA damage and inflammation in hepatocyte cells.…”

Section: Dieckolmentioning

confidence: 99%

Call the Eckols: Present and Future Potential Cancer Therapies

et al. 2022

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In recent years, an increased interest in marine macroalgae bioactive compounds has been recorded due to their benefits to human health and welfare. Several of their bioactivities have been demonstrated, such as anti-inflammatory, antioxidant, anticarcinogenic, antibacterial and antiviral behavior. However, there still lacks a clear definition regarding how these compounds exert their bioactive properties. Of all the bioactive compounds derived from marine macroalgae, attention has been focused on phenolic compounds, specifically in phlorotannins, due to their potential for biomedical applications. Phlorotannins are a diverse and wide group of phenolic compounds, with several structural variations based on the monomer phloroglucinol. Among the diverse phlorotannin structures, the eckol-family of phlorotannins demonstrates remarkable bioactivity, notably their anti-tumoral properties. However, the molecular mechanisms by which this activity is achieved remain elusive and sparse. This review focuses on the described molecular mechanisms of anti-tumoral effects by the eckol family of compounds and the future prospects of these molecules for potential application in oncology therapies.

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“…For instance, superoxide dismutase (SOD) and catalase (CAT), which are two important detoxifying enzymes that are usually downregulated in cells under oxidative stress, were shown to be increased on different cell lines treated either with phlorotannin-rich extracts (from F. vesiculosus , F. serratus , Pelvetia canaliculata and A. nodosum ) [ 43 , 51 , 52 ] or isolated phlorotannin compounds including phloroglucinol, eckol, eckstolonol, dieckol and triphlorethol A [ 31 , 32 , 48 , 49 , 68 , 69 , 70 ]. Likewise, glutathione (GSH), GSH peroxidase (GPx), GSH reductase (GR) and GSH-S-transferase (GST), which are crucial players in the neutralization of ROS and intimately associated to the maintenance of the redox balance in living organisms, were reported in multiple studies to be upregulated in response to the treatment of A. nodosum , H. elongata , F. serratus , F. vesiculosus , Pelvetia canaliculata , E. cava and Eisenia bicyclis phlorotannin extracts [ 45 , 50 , 51 , 71 ] as well as to phloroglucinol, triphlorethol A, eckol, phlorofucofuroeckol A, 7-phloroeckol and 6,6′-bieckol [ 31 , 34 , 65 , 70 , 72 ]. As reported by the authors, it is possible that phlorotannins may interfere with the transcriptional activity of the nuclear factor erythroid 2-related factor 2 (Nrf2), which is the major regulator of the phase II detoxifying enzymes [ 73 ].…”

Section: The Contribution Of Phlorotanninsmentioning

confidence: 99%

“…Similar observations were described for phlorofucofuroeckol A, which inhibited the phosphorylation of p38, ERK and JNK in LPS-stimulated Raw 264.7 cells [ 96 ], and for phloroglucinol, which blocked the phosphorylation of ERK in HT1080 cells [ 54 ], both resulting in the suppression of AP-1 activity, another transcription factor involved in the regulation of some pro-inflammatory mediators such as matrix metalloproteinases, a group of enzymes involved in the tissue remodeling during chronic inflammation and cell motility further in a tumor environment. The inhibitory effects of these and other isolated phlorotannins such as eckol, eckstolonol, 6,6′-bieckol, 8,8′-bieckol, fucofuroeckol-A over NF-κB and MAPKs have been reported in multiple cell lines elicited with different pro-inflammatory stimulus, including LPS-induced BV2 microglia cells, THP-1 or Raw 264.7 macrophages, Aβ 25–35 -stimulated PC12 pheochromocytoma cells, PMA-induced MG-63 human osteosarcoma cells, high glucose-induced HUVEC endothelial cells, hypoxia-induced primary mouse hepatocytes and gamma-irradiated primary rat hepatocytes [ 46 , 65 , 81 , 82 , 88 , 89 , 106 , 109 , 110 , 111 , 112 ], suggesting that these compounds may act in a wide range of inflammatory conditions.…”

Section: The Contribution Of Phlorotanninsmentioning

confidence: 99%

Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

Catarino

Amarante

Mateus

et al. 2021

Foods

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According to the WHO, cancer was responsible for an estimated 9.6 million deaths in 2018, making it the second global leading cause of death. The main risk factors that lead to the development of this disease include poor behavioral and dietary habits, such as tobacco use, alcohol use and lack of fruit and vegetable intake, or physical inactivity. In turn, it is well known that polyphenols are deeply implicated with the lower rates of cancer in populations that consume high levels of plant derived foods. In this field, phlorotannins have been under the spotlight in recent years since they have shown exceptional bioactive properties, with great interest for application in food and pharmaceutical industries. Among their multiple bioactive properties, phlorotannins have revealed the capacity to interfere with several biochemical mechanisms that regulate oxidative stress, inflammation and tumorigenesis, which are central aspects in the pathogenesis of cancer. This versatility and ability to act either directly or indirectly at different stages and mechanisms of cancer growth make these compounds highly appealing for the development of new therapeutical strategies to address this world scourge. The present manuscript revises relevant studies focusing the effects of phlorotannins to counteract the oxidative stress–inflammation network, emphasizing their potential for application in cancer prevention and/or treatment.

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Radioprotective efficacy of dieckol against gamma radiation-induced cellular damage in hepatocyte cells

Cited by 8 publications

References 54 publications

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

Call the Eckols: Present and Future Potential Cancer Therapies

Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

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