Radiosensitive Adamantinoma

Hair, J. A. G.

doi:10.1136/bmj.1.5323.105-a

Cited by 18 publications

(2 citation statements)

References 4 publications

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“…In man, radiotherapy, as the primary treatment modality for ameloblastomas, generally is discouraged because ameloblastomas are thought to be radioresistant [ 151. Favorable radiation responses of ameloblastomas [6] and recommendations to use radiotherapy for the management of ameloblastomas [ 121 can be found. No welldesigned prospective clinical trial evaluating the radiation response of ameloblastomas in man could be found.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastoma and Keratinizing Ameloblastoma in Dogs

Dubielzig

Thrall

1982

Vet Pathol

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Abstract. Ameloblastomas reviewed in this report were locally invasive neoplasms arising from the epithelial structures of the dental lamina, and were characterized histologically by features which are unique to dental lamina epithelium. These include the formation of epithelial sheets in which the cells nearest the stroma form a palisading row aligned perpendicularly to the basement membrane and the cells toward the center separate from each other except at desmosomal attachments. This is similar to the appearance of the stellate reticulum of the early enamel organ. Other features include epithelial cords which branch and interconnect, and the intimate association of epithelial structures and collagenous matrix. In our dogs, other important features were the deposition of inclusions similar in appearance to enamel matrix between the cells of the epithelium and various degrees of keratinization. All ameloblastomas studied were locally invasive tumors which occurred at various sites on the gingiva. The average age of the dogs was 8.7 years and the age range was three to 13 years. Radiographically, all of the tumors studied resulted in periodontal osteolysis. Six dogs were treated with radiation therapy, but details of the radiotherapy of two dogs could not be located. Of the other four dogs, one is alive 48 months after radiotherapy with no evidence of tumor regrowth. Regrowth of the oral tumor was apparent in the other three dogs six, 21, and 34 months after completion of the radiotherapy.Three dogs were treated by radical mandibulectomy; all are alive with no evidence of tumor recurrence at two, 20, and 28 months postoperatively. Two dogs had local dissection (curettage) of tumors and the tumors recurred at 12 and 15 months after surgery. One dog was euthanatized after diagnosis of the oral tumor because of a progressive neuropathy.

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Section: Discussionmentioning

confidence: 99%

Ameloblastoma and Keratinizing Ameloblastoma in Dogs

Dubielzig

Thrall

1982

Vet Pathol

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“…For the occasional patient who is not a suitable candidate for surgery, temporary resolution has been reported following radiotherapy despite the poor long term results (Hair, 1963;Shaw and Katsakis, 1973).…”

Section: Discussionmentioning

confidence: 99%

Ameloblastoma presenting as nasal obstruction Case reports

et al. 1988

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Ameloblastoma of the jaw. A reappraisal of the role of megavoltage irradiation

Atkinson

Harwood

Cummings

1984

Cancer

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Ten patients with ameloblastoma of the jaw were treated with megavoltage irradiation between 1958 and 1982. Seven cases were treated with radiation alone and six responded initially. One patient subsequently recurred and was successfully salvaged surgically. Three patients were treated with combined radiation therapy and surgery. Carefully applied megavoltage irradiation has a useful role in the management of ameloblastoma, particularly in large maxillary tumors with associated destruction of the infrastructure of the maxillary antrum. It is apparent from this series, and from the literature, that the ameloblastoma is not an inherently radioresistant tumor.

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Radiosensitive Adamantinoma

Cited by 18 publications

References 4 publications

Ameloblastoma and Keratinizing Ameloblastoma in Dogs

Ameloblastoma and Keratinizing Ameloblastoma in Dogs

Ameloblastoma presenting as nasal obstruction Case reports

Ameloblastoma of the jaw. A reappraisal of the role of megavoltage irradiation

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