Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma

Chung, Peter; Deheshi, Benjamin; Ferguson, Peter C.; Wunder, Jay S.; Griffin, Anthony M.; Catton, Charles; Bell, Robert S.; White, Lawrence M.; Kandel, Rita A.; O’Sullivan, Brian

doi:10.1002/cncr.24375

Cited by 163 publications

(132 citation statements)

References 35 publications

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“…Estimated 5-year local recurrence-free survival remained high (88.2%), similar to our historical rate of 89.6% in extremity STS treated with surgery and external beam RT. 26 Because all patients have been followed for at least 2 years, this rate is unlikely to change substantially. The Memorial Sloan-Kettering Cancer Center group also found no increase in local relapse risk with IMRT, with a 5-year estimated local control rate of 94%, 10 decreasing to 92% when updated with additional patients in 2011.…”

Section: Discussionmentioning

confidence: 99%

Phase 2 study of preoperative image‐guided intensity‐modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma

O’Sullivan

Griffin

Dickie

et al. 2013

Cancer

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211

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BACKGROUND: This study sought to determine if preoperative image‐guided intensity‐modulated radiotherapy (IG‐IMRT) can reduce morbidity, including wound complications, by minimizing dose to uninvolved tissues in adults with lower extremity soft tissue sarcoma. METHODS: The primary endpoint was the development of an acute wound complication (WC). IG‐IMRT was used to conform volumes to avoid normal tissues (skin flaps for wound closure, bone, or other uninvolved soft tissues). From July 2005 to June 2009, 70 adults were enrolled; 59 were evaluable for the primary endpoint. Median tumor size was 9.5 cm; 55 tumors (93%) were high‐grade and 58 (98%) were deep to fascia. RESULTS: Eighteen (30.5%) patients developed WCs. This was not statistically significantly different from the result of the National Cancer Institute of Canada SR2 trial (P = .2); however, primary closure technique was possible more often (55 of 59 patients [93.2%] versus 50 of 70 patients [71.4%]; P = .002), and secondary operations for WCs were somewhat reduced (6 of 18 patients [33%] versus 13 of 30 patients [43%]; P = .55). Moderate edema, skin, subcutaneous, and joint toxicity was present in 6 (11.1%), 1 (1.9%), 5 (9.3%), and 3 (5.6%) patients, respectively, but there were no bone fractures. Four local recurrences (6.8%, none near the flaps) occurred with median follow‐up of 49 months. CONCLUSIONS: The 30.5% incidence of WCs was numerically lower than the 43% risk derived from the National Cancer Institute of Canada SR2 trial, but did not reach statistical significance. Preoperative IG‐IMRT significantly diminished the need for tissue transfer. RT chronic morbidities and the need for subsequent secondary operations for WCs were lowered, although not significantly, whereas good limb function was maintained. Cancer 2013. © 2013 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Phase 2 study of preoperative image‐guided intensity‐modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma

O’Sullivan

Griffin

Dickie

et al. 2013

Cancer

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211

139

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“…Typically, delicate plexiform vasculature with perivascular sclerosis, hyalinizing rosettes, strong cytoplasmic staining with MUC4 are present [12]. Finally, low grade myxofibrosarcoma, on the other hand, is characterized by fusiform tumor cells, with indistinct cell borders, slightly eosinophilic or vacuolated cytoplasm, and varying degree of hyperchromatic atypical nuclei, set in a myxoid or fibromyxoid matrix containing elongated, curvilinear capillaries with perivascular cell condensation [13][14][15][16][17][18]. However, the absence of lipoblasts and diffuse positive staining for S100 aid the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Paratesticular Myxoid Liposarcoma: A Case Report of Unusual Age of Presentation

Al‐Obaidy¹,

Abdulfatah²,

Lonardo³

et al. 2017

J Mol Biomark Diagn

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Paratesticular liposarcomas are relatively common sarcomas in the paratesticular region, however, the myxoid variant; myxoid liposarcoma (MLS) is considered very rare. MLS peaks around the fourth-fifth decade. Herein, we describe a case of paratesticular MLS occurring in a 19-year-old African American male who underwent resection of a slowly growing testicular mass over a period of one and a half years that was considered initially by his primary care physician to be a benign lesion. The resection margins were positive for tumor and the patient developed local recurrence one year after the initial resection. An extremely unusual age of presentation along with the importance of margin status in tumor recurrence is highlighted.

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“…6 Different studies have suggested that MLS tends to be relatively more radiosensitive than other types of STS, with high rates of regression and even complete clinical response. 7 The National Comprehensive Cancer Network (NCCN) panel guidelines for stage II-III MLS are: For resectable tumors, surgery followed by radiotherapy is the primary treatment. If the tumor is unresectable, neoadjuvant therapies (radiotherapy, chemoradiation, chemotherapy) are recommended primarily, even if some authors have not found any improvement in overall survival.…”

Section: Discussionmentioning

confidence: 99%