Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-Like Cells by Inhibiting Autophagy In Vitro and In Vivo

Yuan, Ke; Li, Y.; Zeng, Yongquan; Ye, Zhong; Xie, Conghua; Yu, Haijun

doi:10.1016/j.ijrobp.2018.07.617

Cited by 5 publications

(4 citation statements)

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“…As a consequence, the sensitivity of tumor tissue to radiotherapy and chemotherapy is reduced by Zn‐induced protective autophagy. For example, removing excess Zn in nasopharyngeal cancer cells (CNE‐2 cells) can enhance their sensitivity to radiotherapy (Ke et al, 2020). Moreover, the Zn chelator promotes pancreatic cell apoptosis via inhibition of autophagy (Yu et al, 2019d).…”

Section: Metals‐induced Autophagy and Diseasesmentioning

confidence: 99%

Transition metals and metal complexes in autophagy and diseases

Luo

Huang

et al. 2021

Journal Cellular Physiology

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Transition metals refer to the elements in the d and ds blocks of the periodic table. Since the success of cisplatin and auranofin, transition metal‐based compounds have become a prospective source for drug development, particularly in cancer treatment. In recent years, extensive studies have shown that numerous transition metal‐based compounds could modulate autophagy, promising a new therapeutic strategy for metal‐related diseases and the design of metal‐based agents. Copper, zinc, and manganese, which are common components in physiological pathways, play important roles in the progression of cancer, neurodegenerative diseases, and cardiovascular diseases. Furthermore, enrichment of copper, zinc, or manganese can regulate autophagy. Thus, we summarized the current advances in elucidating the mechanisms of some metals/metal‐based compounds and their functions in autophagy regulation, which is conducive to explore the intricate roles of autophagy and exploit novel therapeutic drugs for human diseases.

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Section: Metals‐induced Autophagy and Diseasesmentioning

confidence: 99%

Transition metals and metal complexes in autophagy and diseases

Luo

Huang

et al. 2021

Journal Cellular Physiology

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“…22 However, several studies have proven that autophagy may reduce chem-or radio-resistance. [23][24] For example, inhibition of autophagy in esophageal carcinoma can improve the radiosensitivity of cancer cells. 25 Similarly, 3-methyladenine (3-MA), an autophagy inhibitor, sensitizes radio-resistant HepG2 cells to radiationinduced cytotoxicity, 26 proving that modulating autophagy is a powerful method in treating HCC.…”

Section: Discussionmentioning

confidence: 99%

Tenacissoside H Induces Autophagy and Radiosensitivity of Hepatocellular Carcinoma Cells by PI3K/Akt/mTOR Signaling Pathway

et al. 2021

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Tenacissoside H (TEH), which has anti-inflammatory and anti-tumor effects, is a major active ingredient extracted from the stem of Marsdenia tenacissima. However, the effect of TEH on hepatocellular carcinoma (HCC) as well as the underlying mechanisms are still indistinct. Presently, HCC cells (including Huh-7 and HepG2) were dealt with different concentrations of TEH. The proliferation and apoptosis of HCC cells were determined via Cell Counting Kit-8 (CCK8) assay and flow cytometry. In addition, Western blot was conducted to evaluate the expressions of autophagy—and apoptosis-related proteins. Tissue immunofluorescence was carried out to evaluate LC3B expression in the tumor tissues. The data showed that TEH suppressed the growth of HCC cells in a concentration-dependent manner. Besides, TEH enhanced radiosensitivity and promoted the apoptosis of HCC cells. Moreover, the mRNA and protein levels of autophagy-related genes (LC3-II/LC2-I, ATG5, Beclin-1) were significantly promoted by TEH. Mechanistically, TEH attenuated the activation of PI3K/Akt/mTOR signaling pathway. However, inhibition of PI3 K pathway abolished the anti-tumor effects of TEH in HCC cells. Collectively, this study suggested that TEH increases the radiosensitivity of HCC cells via inducing autophagy and apoptosis through downregulating PI3K/Akt/mTOR signaling pathway.

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“…Then we further demonstrated that clioquinol combined with Zinc could inhibit NF-kB activity and leading cancer cells apoptosis [19]. The recent studies found that transferring Zinc into cells could also increase the radiosensitivity of nasopharyngeal cancer stem-like cells [20,21]. However, there were rarely studies to explore the influence of overloaded Zinc on ovarian cancer and the drug-resistant cells.…”

Section: Introductionmentioning

confidence: 91%