Radiosensitization of Uterine Cancer Cell Lines by Cytotoxic Agents

Nguyen, Hoa N.; Sevin, Bernd‐Uwe; Averette, Hervy E.; Gottlieb, C.F.; Perras, James P.; Donato, Daniel; Peñalver, Manuel

doi:10.1006/gyno.1993.1004

Cited by 6 publications

(5 citation statements)

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“…The combined effect of X-rays and cisplatin has been extensively studied in the preclinical setting; however, there are no firm conclusions as to whether the effects are synergistic or purely additive because results vary widely from marked synergism to none at all (Supplementary Table 1)89101112131415161718192021. Furthermore, the presence/absence of synergism is inconsistent even between studies using the same cell lines (i.e., Agoni et al vs. Flentje et al .…”

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Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin

Kobayashi

Oike

Shibata

et al. 2017

Sci Rep

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In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant carbon ions and cisplatin is unclear. To obtain the information on the mechanisms potentially shared between carbon ions or X-rays and cisplatin, we assessed the correlation of sensitivity to the single treatments. In 20 human cancer cell lines, sensitivity to X-rays strongly correlated with sensitivity to cisplatin, indicating the presence of potentially shared target mechanisms. Interestingly, the correlation of sensitivity to carbon ions and cisplatin was much weaker than that of sensitivity to X-rays and cisplatin, indicating the presence of potentially different target mechanisms between carbon ions and cisplatin. Assessment of clonogenic cell death by 4′,6-diamidino-2-phenylindole dihydrochloride staining showed that mitotic catastrophe was more efficiently induced by carbon ions than by the same physical dose of X-rays, while apoptosis and senescence were not. These data indicate that the correlation of sensitivity to carbon ions and cisplatin is weaker than that of sensitivity to X-rays and cisplatin, which are helpful as biological basis to understand the potentially shared mechanism among these treatments. Further investigation is mandatory to elucidate the clinical efficacy of carbon ions and cisplatin combination.

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confidence: 99%

Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin

Kobayashi

Oike

Shibata

et al. 2017

Sci Rep

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“…Some investigators, on the other hand, have not found any enhancement in vivo (33) or in vitro (8,9). Nguyen et al in 1993 studied the concomitant use of chemotherapeutic agents, including cisplatin, and radiation on endometrial cancer cell lines (13). Their results, using non-clonogenic ATP bioluminescence assay, indicated that the effect of cisplatin and radiotherapy was synergistic.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, only one study of this type has used endometrial carcinoma cell lines ( 13). The sensitivity of endometrial carcinoma to cisplatin varies greatly in vitro.…”

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Simultaneous Cisplatin and Radiation in Endometrial Adenocarcinoma Cell Lines

et al. 1995

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“…31 The aim of this study was to ascertain the role played by the Her-2/neu and T2a oncogenes in chromosome 17q gains of thymic neoplasia, its impact on tumor biology, possible and likely relation between T2a and response to the CAP regimen, and survival. Retrospective evaluation of Her-2/neu and T2a gene amplification by fluorescence in situ hybridization (FISH) was performed followed by determination of protein expression by immunohistochemistry (IHC) for T2a protein; excision repair cross-complementing protein-1 (ERCC-1) overexpression portends resistance to platinum drugs 32 ; and thymidylate synthase (TS) overexpression portends resistance to 5FU.…”

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Topoisomerase 2α plays a pivotal role in the tumor biology of stage IV thymic neoplasia

Liu

Wang

Huang

et al. 2006

Cancer

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BACKGROUND.Microsatellite studies in histologic types B3 and C thymic neoplasia detected gains on chromosome 17q, which contains the Her‐2/neu and its juxtaposed topoisomerase 2α (T2α) genes. The study aimed to evaluate their impact on tumor biology and survival of advanced thymic neoplasia patients.METHODS.From 1991 to 2005, 36 consecutive stage IV thymic carcinoma patients were treated, 18 men and 18 women, aged 11 to 84 years. There were 22 thymic carcinoma, 13 type B3, and 1 type B2 thymoma. Patients received treatment consisting of surgical resection, combination chemotherapy with the CAP (cyclophosphamide, Adriamycin, cisplatin) regimen, or radiation therapy potentiated by high‐dose weekly 5‐fluorouracil infusion. Permutations of these 3 treatment modalities were prescribed as necessary.RESULTS.T2α gene amplification was detected in 4 of 14 thymic carcinoma and 1 of 15 type B3 thymoma. Three thymic carcinoma patients had Her‐2/neu coamplification and these 3 patients had rapidly growing tumor and extensive disease at initial diagnosis. CAP was prescribed in 28 patients and 20 patients responded (response rate, 71.4%, 95% confidence interval [CI]: 52.8% to 85%); all responders overexpressed (≥10% nuclei positive) the T2α protein, whereas 4 nonresponders had very low expression. T2α overexpression predicts CAP response, and its absence predicts resistance (P = .001). Overall survival was significantly prolonged if the tumor was resectable (P = .001), of type B3 histology (P = .0039), and had no Her‐2 gene amplification (P = .0081).CONCLUSION.T2α and Her‐2/neu genes play a pivotal role in the tumor biology, CAP response, and survival of advanced thymic neoplasia patients. Cancer 2007;109:502–509. © 2006 American Cancer Society.

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Radiosensitization of Uterine Cancer Cell Lines by Cytotoxic Agents

Cited by 6 publications

References 0 publications

Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin

Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin

Simultaneous Cisplatin and Radiation in Endometrial Adenocarcinoma Cell Lines

Topoisomerase 2α plays a pivotal role in the tumor biology of stage IV thymic neoplasia

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