Radiostability of pharmaceuticals under different irradiation conditions

Crucq, A.; Deridder, Véronique; Tilquin, Bernard

doi:10.1016/j.radphyschem.2004.02.006

Cited by 24 publications

(10 citation statements)

References 9 publications

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“…These observations indicate a negligible influence of the dose rate (in the range from 300 to 6 Â 10 7 Gy h j1 ) on the radiolysis mechanisms of solid-state metoclopramide, as previously observed for other drugs (20).…”

Section: Influence Of the Dose Ratesupporting

confidence: 81%

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Electron Beam and Gamma Radiolysis of Solid-State Metoclopramide

et al. 2006

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Section: Influence Of the Dose Ratesupporting

confidence: 81%

“…The coloration can either be due to the formation of a radiolytic product that absorbs in the visible region and gives a colored solution after dissolution (20,21) or, as in our case, to electrons trapped in the solid matrix that may be responsible for the color.…”

Section: Color Modificationmentioning

confidence: 87%

Electron Beam and Gamma Radiolysis of Solid-State Metoclopramide

et al. 2006

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“…As reviewed above, the direct and indirect actions of ionizing irradiation lead to chemical alterations in the molecular structure of carbohydrates. Monitoring for dose consistency, as well as the safety and quality of irradiated food9, 10 and pharmacological preparations,11–13 where sugars are used as a binder, has gained considerable attention from safety and regulatory perspectives. In addition, investigation of sugar radicals gained increasing attention after the discovery of their role in DNA strand breakage 14–16.…”

Section: Introductionmentioning

confidence: 99%

Rapid evaluation and discrimination of γ‐irradiated carbohydrates using FT‐Raman spectroscopy and canonical discriminant analysis

Kizil

Irudayaraj

2007

J Sci Food Agric

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Chemical changes induced by gamma irradiation of selected sugar systems -honey and fructose -were investigated through their molecular fingerprint using Fourier transform Raman spectroscopy (FT-Raman). Generalized two-dimensional (2-D) correlation spectroscopy was applied to FT-Raman spectra of the control and 17 kGy irradiated fructose to elucidate changes in the chemical structure upon irradiation. The irradiation induced changes in the ring (below 700 cm −1 ) and conformational structure (800-1500 cm −1 ) of fructose were identified by means of a 2-D FT-Raman correlation spectroscopy. The irradiation damage depicted from the C-H stretch region (2800-3000 cm −1 ) of the FT-Raman spectra of honey was used to develop a pattern recognition model for classifying honey based on the irradiation dose. A hybrid partial least squares (PLS)-canonical variate analysis (CVA) with the optimum number of factors from PLS was used for rapid discrimination of honeys irradiated at 1, 5, 10 or 17 kGy. The present study demonstrated that FT-Raman spectroscopy, together with chemometrics, could be a rapid tool for classification of foodstuffs with high sugar content and provides a viable option to explore radiation-induced modifications to sugar systems subjected to irradiation processing.

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“…A similar interpretation of the color changes has been given by other authors. 31,32 The above-proposed mechanism of SMX radiolysis incited by e-beam irradiation is different from that proposed earlier for this compound radiolysis caused by gamma irradiation. 16 Although in both cases, the radiolysis was found to include the breaking of the S-N bond, gamma irradiation was found to attack the isoxasole ring and thus lead to formation of two products: carbon oxide sulfide and acetaldehyde.…”

Section: Resultsmentioning

confidence: 68%