Radiosurgery for Brain Metastases From Unknown Primary Cancers

Niranjan, Ajay; Kano, Hideyuki; Khan, Aftab Alam; Kim, In-Young; Kondziolka, Douglas; Flickinger, John C.; Lunsford, L. Dade

doi:10.1016/j.ijrobp.2009.07.012

Cited by 21 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At our institution, we have established a long history of SRS for brain metastases using the Gamma Knife [34][35][36] , including experience with radiosurgery to the resection cavity [7] . Others have similarly demonstrated the efficacy of Gamma Knife radiosurgery in the adjuvant setting [37][38][39] .…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Radiosurgery to the Resection Cavity of Brain Metastases: A Retrospective Analysis and Literature Review

Rwigema¹,

Wegner²,

Mintz³

et al. 2011

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

Purpose: The aim of this study was to analyze results of stereotactic radiosurgery (SRS) as adjuvant therapy for resected brain metastases. Methods: Medical records of patients treated at a single institution with SRS to the postoperative cavity of brain metastases were retrospectively reviewed. Patients who completed the prescribed SRS regimen following gross-total resection and had no previous whole brain radiotherapy were included in the study. Kaplan-Meier analyses were used to estimate local (LC) and intracranial control (IC), and overall survival (OS) rates. Results: Between April 2005 and July 2010, 77 patients (median age 63 years) with 89 metastases met the inclusion criteria. The median prescription dose was 18 Gy (12–27 Gy) delivered in 1–3 fractions for a median target volume of 7.6 cm³ (0.5–59 cm³). The 6-month, 1-year, and 2-year LC rates were 76.1, 76.1, and 74.3%, respectively. The 6-month, 1-year, and 2-year IC rates were 75.2, 54, and 43.6%, respectively. With a median follow-up of 13.8 months, the median OS was 14.5 months (1.9–51.4 months) after SRS. The overall 6-month, 1-year, and 2-year OS rates were 91, 62.5, and 43.6%, respectively. Complications included 2 patients with radiation necrosis. Conclusion: Adjuvant radiosurgery to the tumor cavity of resected brain metastases is well-tolerated and achieves LC in the majority of patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Stereotactic Radiosurgery to the Resection Cavity of Brain Metastases: A Retrospective Analysis and Literature Review

Rwigema¹,

Wegner²,

Mintz³

et al. 2011

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

show abstract

“…1F), and multiple brain metastases (Fig. Although several studies have documented the negative prognostic effect of multiple metastases, more recently focus has shifted toward total tumor burden, i.e., the total volume of metastases, rather than the absolute number of metastases per se (38). Although several studies have documented the negative prognostic effect of multiple metastases, more recently focus has shifted toward total tumor burden, i.e., the total volume of metastases, rather than the absolute number of metastases per se (38).…”

Section: Prognostic Factorsmentioning

confidence: 99%

“…1G) were significant negative prognostic factors for survival. Although several studies have documented the negative prognostic effect of multiple metastases, more recently focus has shifted toward total tumor burden, i.e., the total volume of metastases, rather than the absolute number of metastases per se (38).…”

Section: Prognostic Factorsmentioning

confidence: 99%

Craniotomy for brain metastases: a consecutive series of 316 patients

Rogne

Rønning

Helseth

et al. 2011

Acta Neurologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…A postprocedure oral steroid taper was then outlined for each patient, with a goal to wean them off corticosteroids during the subsequent 3 weeks. 19,21 To meet inclusion criteria, all patients had metastatic tumors ≥ 1.5 cm in greatest dimension, and the lesions were either located within the precentral gyrus of the motor cortex or located directly adjacent to the precentral gyrus. Typical tumors are shown in Fig.…”

mentioning

confidence: 99%