Radiosurgery for glomus jugulare: history and recent progress

Guss, Zachary D.; Batra, Sachin; Li, Gordon; Chang, Steven D.; Parsa, Andrew T.; Rigamonti, Daniele; Kleinberg, Lawrence; Lim, Michael

doi:10.3171/2009.9.focus09195

Cited by 38 publications

(33 citation statements)

References 48 publications

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“…23 Their incidence in the general population is only 1 in 1.3 million, and they grow very slowly. 13 Jansen and colleagues estimated the growth rate of these tumors to be 0.79 mm per year. 17 Because JTPs are seen so infrequently, it is difficult to find large numbers of patients to study.…”

Section: Discussionmentioning

confidence: 99%

Jugulotympanic paragangliomas treated with Gamma Knife radiosurgery: a single-center review of 58 cases

Gandía-González

Kusak

Moreno

et al. 2014

JNS

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Object Jugulotympanic paragangliomas (JTPs) are rare benign tumors whose surgical treatment is usually associated with partial resection of the lesion, high morbidity, and even death. Gamma Knife radiosurgery (GKRS) has been reported as a useful treatment option. The goal of this retrospective study is to analyze the role of GKRS in tumor volume control and clinical outcomes of these patients. Methods A total of 75 patients with JTPs were treated with GKRS at the authors' center from 1995 to 2012. The authors analyzed those treated during this period to allow for a minimal observation time of 2 years. The MR images and clinical reports of these patients were reviewed to assess clinical and volumetric outcomes of the tumors. The radiological and clinical assessments, along with a group of prognostic factors measured, were analyzed using descriptive methods. The time to volumetric and clinical progression was analyzed using the Kaplan-Meier method. Prognostic factors were identified using log-rank statistics and multivariate Cox regression models. Results The mean follow-up was 86.4 months. The authors observed volumetric tumor control in 94.8% of cases. In 67.2% of cases, tumor volume decreased by a mean of 40.1% from the original size. Of patients with previous tinnitus, 54% reported complete recovery. Improvement of other symptoms was observed in 34.5% of cases. Overall, clinical control was achieved in 91.4% of cases. Previous embolization and familial history of paraganglioma were selected as significant prognostic factors for volumetric response to GKRS treatment in the univariate analysis. In multivariate analysis, no factors were significantly correlated with progression-free survival. No patient died of side effects related to GKRS treatment or tumor progression. Conclusions Gamma Knife radiosurgery is an effective, safe, and efficient therapeutic option for the treatment of these tumors as a first-line treatment or in conjunction with traditional surgery, endovascular treatment, or conventional fractionated radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Jugulotympanic paragangliomas treated with Gamma Knife radiosurgery: a single-center review of 58 cases

Gandía-González

Kusak

Moreno

et al. 2014

JNS

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“…50,51 Nonetheless, these tumors represent the second most common tumor of the temporal bone. They are highly vascularized tumors that arise from the paraganglia of the chemoreceptor structures of the lower cranial nerves.…”

Section: Stereotactic Radiosurgery For Glomus Jugulare Tumorsmentioning

confidence: 99%

Stereotactic Radiosurgery in the Management of Vestibular Schwannoma and Glomus Jugulare

Jacob

Pollock

Carlson

et al. 2015

Otolaryngologic Clinics of North America

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“…These tumours present a significant challenge owing to their location and large size at presentation 4. The common presenting symptoms are tinnitus, decreased hearing, ear pain and vertigo 5. In some cases extensive tumours may also involve various cranial nerves 6…”

Section: Introductionmentioning

confidence: 99%

Glomus jugulare: high index of clinical suspicion is important for optimal management

et al. 2013

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Radiosurgery for glomus jugulare: history and recent progress

Cited by 38 publications

References 48 publications

Jugulotympanic paragangliomas treated with Gamma Knife radiosurgery: a single-center review of 58 cases

Jugulotympanic paragangliomas treated with Gamma Knife radiosurgery: a single-center review of 58 cases

Stereotactic Radiosurgery in the Management of Vestibular Schwannoma and Glomus Jugulare

Glomus jugulare: high index of clinical suspicion is important for optimal management

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