Radiosurgery in Cerebral Tumours and AVM

Valentino, V.

doi:10.1007/978-3-7091-8975-7_38

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…Visual disturbances affect higher proportions of adults, as compared to children (Baskin & Wilson 1986). Menstrual disorders occurred in 20% of our patients and loss of libido occurred only in 6%; the corresponding frequencies in the published literature are on the whole higher than this (Valentino 1988); The incidence of diabetes insipidus varies between 5 and 30%, and it was detected in 10% of our patients. Usually higher rates of papilloedema have been reported among children compared with men; a study in Sweden has reported prevalences of 50% and 29% among patients of 20 years of age and older patients respectively (Bulow et al .…”

Section: Discussionmentioning

confidence: 48%

“…The benefits of post-operative radiotherapy were first demonstrated nearly 40 years ago. Subsequent research has confirmed that radiotherapy improves both diseasefree and overall survival rates (Baskin & Wilson 1986;Valentino 1988). Besides common side-effects (such as radionecrosis, optic neuritis and dementia), external conventional radiotherapy carries a high risk of delayed endocrine deficiency.…”

Section: Discussionmentioning

confidence: 98%

“…In adults with hypopituitarism receiving conventional hormone treatment but with unsubstituted growth hormone deficiency, an increased prevalence of premature atherosclerosis as well as cardiovascular risk factors have been observed (Lyen & Grant 1982; Valentino 1988; Bulow et al . 1998; Honegger et al .…”

Section: Discussionmentioning

confidence: 99%

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Presentation and outcome of 93 cases of craniopharyngioma

et al. 2004

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We studied a series of 93 patients diagnosed with craniopharyngioma during a 15-year period with respect to presenting symptom, clinical course and management. The majority (62%) of patients were men, and had presented with neurological symptoms (75%), with headaches (82%) being the most common presenting symptom. The incidence of certain endocrine and ophthalmic symptoms varied little from that in the literature, on the other hand, the incidence of certain other symptoms did differ markedly from the literature. For example, loss of libido and amenorrhoea were seen at a much lower frequency than that stated in the literature. Hypertension, sensorimotor symptoms and urinary incontinence were not seen at all in our patients. In most cases diagnosis was made by a cranial CT scan, which is more sensitive than plain radiography for detection of enlarged sella turcica (69% vs. 24%; P < 0.001). In over 90% of cases, therapy consisted of removal of a variable portion of the tumour, with or without radiotherapy. Post-operative mortality was substantially reduced in cases treated by radiotherapy (P < 0.05). The most common post-operative complications in all cases were recurrence of disease, panhypopituitarism and diabetes insipidus.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 98%

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Presentation and outcome of 93 cases of craniopharyngioma

et al. 2004

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“…Radiosurgery has been proven to be succesful in the treatment of small arteriovenous malformations (AVMs) of the brain [ 16 , 85 , 139 , 142 , 144 , 150 ]. Until now, digital subtraction angiography (DSA) has been a mandatory tool for the planning of these interventions.…”

Section: Avmmentioning

confidence: 99%

Current concepts in stereotactic radiosurgery - a neurosurgical and radiooncological point of view

et al. 2009

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Stereotactic radiosurgery is related to the history of "radiotherapy" and "stereotactic neurosurgery". The concepts for neurosurgeons and radiooncologists have been changed during the last decade and have also transformed neurosurgery. The gamma knife and the stereotactically modified linear accelerator (LINAC) are radiosurgical equipments to treat predetermined intracranial targets through the intact skull without damaging the surrounding normal brain tissue. These technical developments allow a more precise intracranial lesion control and offer even more conformal dose plans for irregularly shaped lesions. Histological determination by stereotactic biopsy remains the basis for any otherwise undefined intracranial lesion. As a minimal approach, it allows functional preservation, low risk and high sensitivity. Long-term results have been published for various indications. The impact of radiosurgery is presented for the management of gliomas, metastases, brain stem lesions, benign tumours and vascular malformations and selected functional disorders such as trigeminal neuralgia. In AVM's it can be performed as part of a multimodality strategy including resection or endovascular embolisation. Finally, the technological advances in radiation oncology as well as stereotactic neurosurgery have led to significant improvements in radiosurgical treatment opportunities. Novel indications are currently under investigation. The combination of both, the neurosurgical and the radiooncological expertise, will help to minimize the risk for the patient while achieving a greater treatment success.

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“…Radiosurgery has been used in the treatment of meningioma for about 30 years. [4] There is no randomized study comparing surgery and radiosurgery yet, but results from radiosurgery studies including large series confirm that radiosurgery can be an alternative to surgery. In a retrospective study comparing radical surgery and radiosurgery in small meningiomas, local control was shown to be similar.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Meningioma Patients Undergoing Stereotactic Radiotherapy

DELİKGÖZ SOYKUT,

AKSAN,

ŞAVLI

et al. 2023

Journal of Contemporary Medicine

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Aim: Innovations in radiotherapy have paved the way for alternative approaches for the treatment of meningioma, and in this context, radiosurgery has begun to be used in the treatment of meningioma. This study aimed to examine the clinical results of radiosurgery in the treatment of meningioma and to show whether it achieves the main goals, especially in terms of the possibility of tumor control and the success of preventing progression. Materials and Methods: Primary, residual, and recurrent meningioma treated with stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) between 2013 and 2020 were evaluated retrospectively. Study endpoints were overall survival (OS), progression free survival (PFS), and local control (LC). Results: 73 patients and 81 lesions were analyzed. The median duration of the follow-up period was 49 months (range, 7–138 months). 5- and 7-y OS and PFS were 87.6%, 78.9%; 82.9% and 82.9%, respectively. The tumor control rate was 94.6%. In univariate analysis, gender (p=0.007), radiosurgery for recurrence (p=0.011) and number of lesions (p=0.030) were found to be factors affecting OS, and number of lesions (p

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Radiosurgery in Cerebral Tumours and AVM

Cited by 10 publications

References 3 publications

Presentation and outcome of 93 cases of craniopharyngioma

Presentation and outcome of 93 cases of craniopharyngioma

Current concepts in stereotactic radiosurgery - a neurosurgical and radiooncological point of view

Outcomes of Meningioma Patients Undergoing Stereotactic Radiotherapy

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