Radiosynthesis and Biodistribution of an<sup>125</sup>I-labeled Resveratrol Derivative

Kim, Sung Kew; Lee, Woong San; Han, Sang Jin; Kim, Eun Jung; El‐Gamal, Mohammed I.; Kim, Byoung Soo; Choi, Tae Hyun; Choi, Chang Woon; Ham, In-Hye; Oh, Chang‐Hyun; Choi, Ho-Young; Cho, Jung‐Hyuck

doi:10.5012/bkcs.2012.33.2.489

Cited by 2 publications

(3 citation statements)

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“…In this disclosure, a nanoparticle and nano-emulsion and their synthesis methods are offered to improve the bioavailability of resveratrol, which is only marginally soluble in water. The nano-emulsions and nanoparticles may deliver resveratrol chemotherapeutics in various tumor milieus [113].…”

Section: Kr20090132357a (Korea Food Research Institute Korea)mentioning

confidence: 99%

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Sarfraz,

Arafat,

Zaidi

et al. 2023

Cancers

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The genesis of cancer is a precisely organized process in which normal cells undergo genetic alterations that cause the cells to multiply abnormally, colonize, and metastasize to other organs such as the liver, lungs, colon, and brain. Potential drugs that could modify these carcinogenic pathways are the ones that will be used in clinical trials as anti-cancer drugs. Resveratrol (RES) is a polyphenolic natural antitoxin that has been utilized for the treatment of several diseases, owing to its ability to scavenge free radicals, control the expression and activity of antioxidant enzymes, and have effects on inflammation, cancer, aging, diabetes, and cardioprotection. Although RES has a variety of pharmacological uses and shows promising applications in natural medicine, its unpredictable pharmacokinetics compromise its therapeutic efficacy and prevent its use in clinical settings. RES has been encapsulated into various nanocarriers, such as liposomes, polymeric nanoparticles, lipidic nanocarriers, and inorganic nanoparticles, to address these issues. These nanocarriers can modulate drug release, increase bioavailability, and reach therapeutically relevant plasma concentrations. Studies on resveratrol-rich nano-formulations in various cancer types are compiled in the current article. Studies relating to enhanced drug stability, increased therapeutic potential in terms of pharmacokinetics and pharmacodynamics, and reduced toxicity to cells and tissues are the main topics of this research. To keep the readers informed about the current state of resveratrol nano-formulations from an industrial perspective, some recent and significant patent literature has also been provided. Here, the prospects for nano-formulations are briefly discussed, along with machine learning and pharmacometrics methods for resolving resveratrol’s pharmacokinetic concerns.

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Section: Kr20090132357a (Korea Food Research Institute Korea)mentioning

confidence: 99%

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Sarfraz,

Arafat,

Zaidi

et al. 2023

Cancers

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“…; Kim et al . ), no data are available on 99m Tc‐labelled resveratrol. Evidently, the diagnostic role of resveratrol or any other phytochemical in cancer is only partially studied and therefore, it is worthwhile to initiate studies to evaluate their role in cancer diagnosis and treatment response.…”

Section: Introductionmentioning

confidence: 99%

“…Despite numerous reports on cancer specificity of resveratrol in experimental and clinical research, the use of polyphenol family for cancer diagnosis is still unknown and unexplored. Although, a few attempts have been made to radiolabel resveratrol with different single photon emission computed tomography (SPECT) and positron emission tomography (PET) radionuclides (Gester et al 2005;Kim et al 2012), no data are available on 99m Tc-labelled resveratrol. Evidently, the diagnostic role of resveratrol or any other phytochemical in cancer is only partially studied and therefore, it is worthwhile to initiate studies to evaluate their role in cancer diagnosis and treatment response.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of ^99m Tc-resveratrol as a colon cancer targeting probe

2016

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The study aimed to evaluate cancer-targeting potential of a newly synthesised radiopharmaceutical, Tc-resveratrol in vivo, using colon cancer model. Colon cancer was induced in 20 male Sprague-Dawley rats by subcutaneous administration of 1,2-dimethylhydrazine (DMH), dissolved in 1 mM EDTA-normal saline, at a dose of 30 mg/kg body weight twice a week for first 4 weeks and once a week for next 12 weeks. A control group containing normal rats was used for result comparison. Colon cancer in DMH-treated group was confirmed by gross analysis of the colon, by histopathological analysis and molecular marker study in tumour tissue. At the end of the treatment period, the animals from the two groups were used for bio-distribution evaluation of Tc-resveratrol at different time intervals. High uptake of Tc-resveratrol was recorded in rat liver, spleen and kidneys, and the ratio of colon tumour uptake to normal colon uptake in DMH-treated rats increased significantly (P ≤ 0.01) with time, to reach a maximum value at 2 h but decreased thereafter. High uptake at the tumour site as compared to normal colon tissue was observed; however, the uptake by cancer cells at the target site was limited by high reticulo-endothelial uptake and rapid metabolism.

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Radiosynthesis and Biodistribution of an¹²⁵I-labeled Resveratrol Derivative

Cited by 2 publications

References 20 publications

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Evaluation of ^99m Tc-resveratrol as a colon cancer targeting probe

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Radiosynthesis and Biodistribution of an125I-labeled Resveratrol Derivative

Cited by 2 publications

References 20 publications

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews

Evaluation of 99m Tc-resveratrol as a colon cancer targeting probe

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Radiosynthesis and Biodistribution of an¹²⁵I-labeled Resveratrol Derivative

Evaluation of ^99m Tc-resveratrol as a colon cancer targeting probe