1989
DOI: 10.1002/jlcr.2580271008
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Radiosynthesis of 15O‐labeled hydrogen peroxide

Abstract: Japan SUMMARY I5O-H2O2 is thought t o be a candidate o f attractive injectable tracers for the study of oxygen metabolism with PET. A simple synthetic method yielding I5O-H 0 in saline solut' n by the autoxidation of 2-ethylanthrahydroquinol with gaseous "0-0, produced by cyclotron target system is described.

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Cited by 7 publications
(4 citation statements)
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“…Muscarinic acetylcholine receptor (MACh‐R) antagonists that have been radiolabeled with carbon‐11 are, for example, [ 11 C]scopolamine, [ 11 C] N ‐methylpiperidyl benzilate, [N‐ 11 C‐methyl]‐benztropine, [ 11 C]3‐quinuclidinyl benzilate, and [ 11 C]3 N ‐methylpiperidyl benzilate . In addition to labeling the total MACh‐R receptor pool, these antagonists are nonselective with regard to MACh‐R subtypes.…”
Section: Introductionmentioning
confidence: 99%
“…Muscarinic acetylcholine receptor (MACh‐R) antagonists that have been radiolabeled with carbon‐11 are, for example, [ 11 C]scopolamine, [ 11 C] N ‐methylpiperidyl benzilate, [N‐ 11 C‐methyl]‐benztropine, [ 11 C]3‐quinuclidinyl benzilate, and [ 11 C]3 N ‐methylpiperidyl benzilate . In addition to labeling the total MACh‐R receptor pool, these antagonists are nonselective with regard to MACh‐R subtypes.…”
Section: Introductionmentioning
confidence: 99%
“…The [ 15 O]O 2 was converted into other 15 O gases, including [ 15 O]CO 2 , [ 15 O]CO, and [ 15 O]N 2 O, under appropriate reductive or oxidative conditions at high temperature . Other essential tracers, for example, [ 15 O]H 2 O 2 , [ 15 O]butanol, and 6‐[ 15 O]‐2‐deoxy‐ d ‐glucose, were also prepared efficiently by the one‐step reaction …”
Section: Labeling Methods With Nitrogen‐13 and Oxygen‐15mentioning
confidence: 99%
“…[ O]-2-deoxy-dglucose,w ere also prepared efficiently by the one-step reaction. [229][230][231] Them ost important 15 O-labeled PET tracer is [ 15 O]H 2 O, which is commonly used for the study of regional cerebral blood flow and metabolism. [232] Several methods for the production of [ 15 O]H 2 Oh ave been reported, [5] including direct bombardment of water using the 16 …”
Section: Ochemistrymentioning
confidence: 99%
“…B. [ 15 O]H 2 O 2 , [ 15 O]Butanol und 6‐[ 15 O]‐2‐Deoxy‐ d ‐glucose, wurden in einer einstufigen Reaktion effizient hergestellt …”
Section: Markierungsmethoden Mit Stickstoff‐13 Und Sauerstoff‐15unclassified