Radiotelemetric versus externalized catheter monitoring of blood pressure: effect of vasopressin in spontaneous hypertension

Balakrishnan, Suchitra; Tatchum-Talom, Rabelais; McNeill, J. Robert

doi:10.1016/s1056-8719(98)00042-2

Cited by 9 publications

(1 citation statement)

References 13 publications

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“…As well, pressure and flow can be recorded for several weeks. BP tends to be lower in hypertensive animals when pressure has been recorded by radiotelemetry, an observation which has been attributed to the longer recovery periods from surgery and the reduced level of stress associated with this technique ( Balakrishnan et al ., 1998 ; Bazil et al ., 1993 ). By recording CO and BP, we were able to calculate TPR, a true measure of the resistance function of the circulation and a better index of vascular responsiveness than BP.…”

Section: Discussionmentioning

confidence: 99%

Role of endothelin and vasopressin in DOCA‐salt hypertension

Gopalakrishnan

McNeill

2001

British J Pharmacology

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1 The relative roles of endothelin (ET) and vasopressin (AVP) in the regulation of blood pressure (BP), cardiac output (CO) and total peripheral resistance (TPR) were investigated in the early stages (24 ± 31 days) of development of hypertension in the conscious deoxycorticosterone acetate (DOCA)-salt hypertensive rat model. 3 In study 1, infusion of bosentan reduced TPR and BP dramatically in DOCA-salt hypertensive rats but not in SHAM control rats, and this eect was greater when the AVP system had been blocked. In contrast, the V 1 receptor antagonist alone failed to change TPR and BP in DOCA-salt hypertensive rats. However, subsequent infusion of the V 1 receptor antagonist during the plateau phase of the response in bosentan pretreated DOCA-salt hypertensive rats led to signi®cant decreases in both BP and TPR. 4 In study 2, TPR and BP responses to ET-1, but not AVP, were greater in DOCA-salt rats than in control rats. CO responses to ET-1 or AVP were similar in the two groups. 5 The results suggest that both ET and AVP play a role in the maintenance of TPR and BP; when one system is blocked the other compensates. However, the magnitude of the contribution to the hypertensive state appears greater for ET than for AVP. Enhanced vascular responses to ET appear to contribute to this greater role.

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Section: Discussionmentioning

confidence: 99%