Radiothérapie et immunosuppression : synthèse de la littérature

Bosacki, Claire; Vallard, Alexis; Jmour, Omar; Mrad, Majed Ben; Lahmamssi, C.; Bousarsar, Amal; Vial, Nicolas; Guillaume, Élodie; Daguenet, Élisabeth; Magné, Nicolas

doi:10.1016/j.bulcan.2019.09.010

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…Characteristics of this case included a long history of treatment with MTX for RA, a low body weight with a body mass index (BMI) of 15.3, and the amount of CDDP being slightly high at 120 mg/mm 2 /time × 5 times. The combination of MTX and radiation therapy is said to potentially cause serious necrosis [7]. According to previous reports, a history of connective tissue diseases such as RA is suggested to be a risk factor for increasing radiation toxicity, which is believed to be involved in the necrosis of the pterygoid muscle in this case [8].…”

Section: Discussionmentioning

confidence: 94%

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Pterygoid Muscle Necrosis Caused by Radiation and Intra-Arterial Cisplatin Infusion Chemotherapy (RADPLAT): A Case Report

Miyamoto,

Sato,

Koike

et al. 2023

Case Rep Oncol

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Introduction: Radiation and intra-arterial cisplatin infusion chemotherapy (RADPLAT) for advanced maxillary sinus cancer has accumulated evidence as a treatment with fewer complications and better 5-year survival rates. In this study, we report a case in which pterygoid muscle necrosis occurred 6 months following RADPLAT treatment for maxillary sinus cancer. Case Presentation: The 45-year-old woman had a long history of taking immunosuppressants against rheumatoid arthritis (RA) prior to treatment. Although achieving complete response (CR) to RADPLAT, the patient developed trismus (1 fingerbreadth or less) 6 months following treatment. Abscess formation and recurrence were suspected from the imaging findings; however, the biopsy with endoscopy indicated necrotic tissue. Currently, 18 months have passed without cancer recurrence. Although trismus temporarily improved with rehabilitation, the width of the mouth opening is currently a few millimeters, so the patient can only take liquid food. Conclusion: Pterygoid muscle necrosis should be recognized as a new major complication.

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Section: Discussionmentioning

confidence: 94%

“…Regarding the mechanism of this complication, the most likely process is that performing RADPLAT under the condition of sustained angiogenesis inhibition influenced by the antifolate effect of MTX resulted in pterygoid muscle necrosis [7]. It is inferred that an infection developed thereafter, causing strong trismus.…”

Section: Discussionmentioning

confidence: 99%