Radiothérapie hypofractionnée des cancers du rectum chez le sujet âgé

Vernat, S. Servagi; Guilbert, Philippe; Bouche, Gauthier; Ramiandrisoa, F.; Bellefqih, S.

doi:10.1016/j.canrad.2018.07.130

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…These patients and their physicians may therefore seek to avoid lengthy RT regimens and associated toxicities. Studies of breast, prostate, and rectal cancer treatment have investigated alternative fractionation regimens for elderly patients in effort to maintain efficacy and improve tolerability 40–42 . This may be a direction for future research in HNC, as highly conformal treatments, hypofractionation, and accessible supportive services may reduce toxicity and make RT a more tolerable and therefore more commonly selected treatment option for elderly patients who would benefit from it.…”

Section: Discussionmentioning

confidence: 99%

Equity in adjuvant radiotherapy utilization in locally advanced head and neck cancer: A SEER‐data based study

et al. 2023

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Background: Not all patients with locally advanced head and neck cancer (HNC) who are eligible for adjuvant radiotherapy (RT) following upfront surgery appear to receive it. Methods: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Selected patients from 2009 to 2018 had locally advanced HNC, underwent upfront surgery, and were eligible for adjuvant RT. Multivariable logistic regression and chi-squared test were used to analyze available patient and tumor characteristics. Results: Of 12 549 patients, 84.5% underwent adjuvant RT, 15.5% did not.Characteristics associated with lowest adjuvant RT utilization included cancers of the larynx (p < 0.0001) and gingivae (p < 0.0001), age 80 and above (p < 0.0001), unpartnered status (p < 0.0001), and residence within a nonmetropolitan area (p < 0.0024). Conclusions: Tumor subsite, age, partnered status, and rural/urban residence correlate with omission of adjuvant RT in locally advanced HNC.

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Section: Discussionmentioning

confidence: 99%

Equity in adjuvant radiotherapy utilization in locally advanced head and neck cancer: A SEER‐data based study

et al. 2023

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Place de la radiothérapie dans le traitement du cancer du rectum chez le sujet âgé

Bisson¹,

André²,

Durand³

et al. 2022

Soins Gérontologie

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Chemoradiotherapy for elderly patients with rectal cancer

Uslu

Rakıcı

2022

Journal of Cancer Research and Therapeutics

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Introduction: The incidence of cancer, particularly rectal cancer (RC), in older adults is gradually increasing. The aim of the present study was to evaluate radiotherapy (RT) and chemoradiotherapy (CRT) results, clinicopathological features, and survival factors in older patients with RC. Methods: We evaluated patients aged ≥65 years with RC treated at a radiation oncology clinic. The demographic, clinical, and histopathological data of the patients were obtained by reviewing their medical records. The toxicity criteria of the Radiation Therapy Oncology Group were applied. Results: Among 401 patients with RC, 183 (45.6%) were older adults (65–92 years). Furthermore, 122 (66.7%) patients had clinically stage 3 and above RC, and 183 and 91 patients received RT and neoadjuvant CRT, respectively. Surgical treatment was performed for 116 (63.4%) patients, 41 (34.4%) and 76 (65.6%) of whom underwent postoperative CRT and preoperative RT, respectively. Grade 3 or higher toxicity was observed in 22 (18.9%) patients during CRT. RT was performed in 64 patients (35%) at a 1–15-day interval. The mean follow-up duration was 34.7 (range, 1.4–149.0) months. The 2- and 5-year overall survival (OS) rates were 71.4 and 37.4%, respectively, and the 2- and 5-year disease-free survival (DFS) rates were 65.7 and 35.3%, respectively. OS was 49.4 and 34.9 months for patients aged 65–74 and ≥75 years, respectively. Survival was shorter in patients with the advanced geriatric disease (p = 0.013). In the multivariate analysis, factors affecting overall and DFS were age, distance from the tumor to the anal canal, and metastasis (p < 0.05). Conclusion: The results of this study suggested that the selection of treatment modalities for older patients with RC should be based on performance status and not age. RT and CRT were safe treatment modalities for older patients with RC, particularly for those who could not undergo surgery.

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Radiothérapie hypofractionnée des cancers du rectum chez le sujet âgé

Cited by 3 publications

References 22 publications

Equity in adjuvant radiotherapy utilization in locally advanced head and neck cancer: A SEER‐data based study

Equity in adjuvant radiotherapy utilization in locally advanced head and neck cancer: A SEER‐data based study

Place de la radiothérapie dans le traitement du cancer du rectum chez le sujet âgé

Chemoradiotherapy for elderly patients with rectal cancer

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