Radiotherapy After Radical Prostatectomy: Adjuvant Versus Salvage Approach

Grob, B. Mayer; Torre, Taryn; Petrossian, Albert

doi:10.1016/b978-0-12-800077-9.00047-5

Cited by 1 publication

(1 citation statement)

References 34 publications

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“…Although such treatments effectively control early stage cancer progression, their associated side effects due to poor tumour selectivity and chemoresistance development remain a major obstacle preventing their full therapeutic potential (Chen, 2000;Chakraborty and Rahman, 2012). Moreover, the recurrence of cancer commonly happens in patients with late-stage cancer, which implied the ineffectiveness of current therapies in treating late-stage cancers (Ciombor and Bekaii-Saab, 2013;Grob et al, 2016). Therefore, novel and effective alternative cancer therapies, including oncolytic virotherapy, are urgently needed to minimize the risk of cancer recurrence and improve the survival rate of cancer patients.…”

Section: Resultsmentioning

confidence: 99%

Oncolytic effect of Newcastle disease virus (NDV) strain AF2240 and V4-UPM on hypoxic and normoxic osteosarcoma cells

Kosni, N. N.,

Abd-Aziz, N.,

Omar, A. R.

et al. 2023

MJM

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Aims: Hypoxia is believed to be one of the key components contributing to the clinical resistance of cancer therapies. Alternative strategies are under investigation to overcome this resistance and the oncolytic virus stands amongst the others. Newcastle disease virus (NDV) has been demonstrated to possess oncolytic activity against cancer cells. The present study investigated the effects of oncolytic NDV strain AF2240 and V4-UPM on osteosarcoma cells (Saos-2) under normoxic and hypoxic conditions. Methodology and results: Results showed that the NDV strain AF2240 and V4-UPM could infect and kill normoxic and hypoxic Saos-2 cells equally well by inducing hypoxia-independent apoptosis, and S-phase cell cycle arrest under the microscopy examination, cell viability assay, Annexin V apoptosis assay and cell cycle analysis experiments. However, the Velogenic NDV strain AF2240 excelled over the lentogenic NDV V4-UPM with increased oncolytic effects in Saos-2 cells. Conclusion, significance and impact of study: In a nutshell, normoxia or hypoxia microenvironment has little effect on NDV-induced oncolysis of Saos-2 cancer cells which poses as a potential agent for the treatment of resistant cancer.

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