Radiotherapy Combined with Transcatheter Arterial Infusion Chemotherapy for Locally Advanced Cervical Cancer

Kitajima, Masaki; Tsutsui, Kazushige; Nagata, Yasushi; Okajima, Kaoru; Katakura, Yukie; Negoro, Yuji; Yamamoto, Masashi; Hiraoka, Masahiro

doi:10.1080/028418698429694

Cited by 6 publications

(7 citation statements)

References 22 publications

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“…A high local control rate has been reported by some investigators (17,19,20,32,35). Also in our study, local recurrence was observed in only 3 patients, including 1 uncontrolled case (10%).…”

Section: Discussionsupporting

confidence: 45%

“…Thus, in Japan it is still uncertain whether CCRT can improve the survival rate in the present report. Table 6 shows treatment results of IAIC in other studies and from the present study (21,24,25,27,29,(31)(32)(33)(35)(36)(37). Intra-arterial infusion chemotherapy is considered useful for improvement of local control because it makes possible high concentrations of drug distribution for the local region and greater antitumor effects and fewer systemic adverse effects than with systemic chemotherapy in CCRT.…”

Section: Discussionmentioning

confidence: 87%

“…In the IAPRT group Grade 3 or 4 late bowel complications were seen in 44% of patients and Grade 3 or 4 myelosuppression in 33%, significantly more than in the RT group. Kokubo et al (32) reported no significant difference between radiotherapy and transcatheter arterial infusion chemotherapy (RT-TAI) and RT-alone groups. However, in the subgroup with well or moderately differentiated squamous cell carcinoma without pelvic lymph node swelling, the cause-specific survival rate in the RT-TAI group was significantly better than in the RT-alone group.…”

Section: Discussionmentioning

confidence: 99%

“…Five-year survival rates for small-medium tumors (n = 17; small 1, medium 16) and large tumors (n = 12) were 74% and 46%, respectively (p = 0.083). Some investigators (32,35,37) have stated that risk factors are tumor size, lymph node metastasis, and pathologic findings. In our study, the 5-year survival rate was 65% in the negative lymph node metastasis group and 51% in the positive lymph node metastasis group, which tended to be better in the negative lymph node metastasis group; however, the differences were not significant.…”

Section: Discussionmentioning

confidence: 99%

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Intra-Arterial Infusion Chemotherapy Using Cisplatin With Radiotherapy for Stage III Squamous Cell Carcinoma of the Cervix

Kaneyasu

Nagai

Nagata

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Intra-Arterial Infusion Chemotherapy Using Cisplatin With Radiotherapy for Stage III Squamous Cell Carcinoma of the Cervix

Kaneyasu

Nagai

Nagata

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…Promising clinical results for combination intraarterial CT and RT have been reported for various tumors. 35 Unfortunately, no randomized clinical trial comparing intraarterial CT with intravenous CT combined with RT has been conducted.…”

Section: Future Directions Of Crtmentioning

confidence: 99%

Rationale for chemoradiotherapy

Nishimura

2004

Int J Clin Oncol

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The rationale for combining chemotherapy (CT) and radiotherapy (RT) is based mainly on two ideas, one being spatial cooperation and the other the enhancement of radiation effects. Spatial cooperation is effective if CT is sufficiently active to eradicate subclinical metastases and if the primary local tumor is effectively treated by RT. In this regard, no interaction between RT and CT is required, but differing toxicities are needed so that both modalities can be used at effective dosages. To enhance RT by CT, five major mechanisms of CT-RT interactions are required. CT can enhance RT effects by: (1) direct enhancement of the initial radiation damage by incorporating drugs into DNA, (2) inhibiting cellular repair, (3) accumulating cells in a radiosensitive phase or eliminating radioresistant phase cells, (4) eliminating hypoxic cells, or (5) inhibiting the accelerated repopulation of tumor cells. However, virtually all chemotherapeutic agents enhance radiation damage to normal tissues as well. Consequently, therapeutic benefits are only achieved if the enhanced tumor response is greater than that for normal tissues. Due to the complex interaction between CT and RT, the sequence of CT and RT is important. Clinical results of induction CT followed by RT are disappointing, and improvements in local control rates of RT by induction CT have not been observed. On the other hand, clinical trials, including metaanalyses, have clearly shown that CT given concurrently with RT results in improved local control and survival. Although acute toxicities are inevitably increased in concurrent chemoradiotherapy (CRT), no significant increases in late toxicities were reported in most clinical trials. Thus, a therapeutic benefit was observed with the use of concurrent CRT.

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Combining Chemotherapy and Radiation Therapy for Liver Cancer: Is the Solution an Intraarterial Approach?

Geschwind¹,

Nezami

2020

Cardiovasc Intervent Radiol

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Radiotherapy Combined with Transcatheter Arterial Infusion Chemotherapy for Locally Advanced Cervical Cancer

Cited by 6 publications

References 22 publications

Intra-Arterial Infusion Chemotherapy Using Cisplatin With Radiotherapy for Stage III Squamous Cell Carcinoma of the Cervix

Intra-Arterial Infusion Chemotherapy Using Cisplatin With Radiotherapy for Stage III Squamous Cell Carcinoma of the Cervix

Rationale for chemoradiotherapy

Combining Chemotherapy and Radiation Therapy for Liver Cancer: Is the Solution an Intraarterial Approach?

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