Radiotherapy Confined to the Tumor Bed Following Breast Conserving Surgery

Polgár, Csaba; Fodor, János; Major, Tibor; Takácsi‐Nagy, Zoltán; Kásler, Miklós; Hammer, J.; Limbergen, Erik; Németh, György

doi:10.1007/s00066-002-0966-z

Cited by 49 publications

(33 citation statements)

References 48 publications

(135 reference statements)

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“…Annak ellenére, hogy a peroxinitrit féléletideje igen rövid (1 s), mégis kifejti ká ros hatását. A sejtek peroxinitritfüggő károsodása függ az intracelluláris redukált glutation (GSH) tar talmuktól; a GSH mennyiségének kísérletes csök kentése fokozza a sejtkárosodást endotoxinaemiá-ban (41). A mitokondriumok különösen érzékenyek a peroxinitrit által okozott károsodásra.…”

Section: Nitrogén-monoxid éS Szén-monoxidunclassified

“…Plafonjelenséget eddig nem észleltek, a lipidértékek normalizálódása az edzésvolumennel töretlennek tűnik. (39,40,41). Az alacsony sűrűségű lipoprotein koleszterin (LDLCh-) és a koleszterin-(Ch-) szintet csak a nagy vo lumenű, sokhónapos edzésperiódus csökkenti szá mottevően.…”

Section: Kulcsszavak: Testmozgás Fizikai Edzés Szérumlipid-és Lipopunclassified

“…Másik, hat hónapos simvastatinkezelést magában foglaló vizsgálatuk ban hasonló eredményt találtak (15). Yoshida és munkatár sai 5 mg-os simvastatinkezelés során azt találták, hogy 28%-os LDL-és 18%-os összkoleszterinszint-csökkenés jött létre változatlan izom-és szérumubikinon-szint mel lett (41). Ezek az eredmények az ubikinon szerepét meg kérdőjelezhetik a myopathia kialakulásában.…”

Section: áBra: a Statinok Hatása Az Intracellularis Koleszterin-anyagunclassified

“…Emlőmegtartáskor a kezelés elen gedhetetlen része a radioterápia. Mastectomia után mint adjuváns kezelés akkor javasolt, ha a daganat lokális kiújulásának veszélye nagy (14,41,44,49,50). Sugárkezelés és emlő-helyreállító műtét együt tes alkalmazása azonban ellentmondásos.…”

Section: Ortográfiaunclassified

“…38 (Suppl. 8), [35][36][37][38][39][40][41][42]M" Rosti,G.,de Vivo,A. és mtsai: A randomized study of interferon-alfa versus interferon-alfa and low-dose arabinosyl cytosine in chronic m yelo id leukemia.…”

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Section: Nitrogén-monoxid éS Szén-monoxidunclassified

Section: Kulcsszavak: Testmozgás Fizikai Edzés Szérumlipid-és Lipopunclassified

Section: áBra: a Statinok Hatása Az Intracellularis Koleszterin-anyagunclassified

Section: Ortográfiaunclassified

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Accelerated partial breast irradiation

Sauer

Sautter-Bihl

Budach

et al. 2007

Cancer

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BACKGROUND. Breast‐conserving surgery followed by whole‐breast radiotherapy (WBRT) has become the standard treatment for the majority of patients with early breast cancer. Whereas the indications for systemic adjuvant treatment have continuously expanded, there is a tendency to restrict postoperative radiotherapy to accelerated partial breast irradiation (APBI) instead of WBRT. METHODS. The different techniques of APBI are described and their respective advantages or potential drawbacks outlined. Moreover, the results described in the literature are briefly reviewed as a basis for the consensus statements and recommendations of the German Society of Radiation Oncology, the German Society of Senology, and the Working Group for Gynecological Oncology of the German Cancer Society. RESULTS. The methods mainly used for APBI are: interstitial radiotherapy with multicatheter technique, intraoperative radiotherapy (IORT) using either electrons produced by linear accelerators or 50 kV x‐rays (Intrabeam), the balloon‐catheter technique (MammoSite), or 3D conformal external beam radiotherapy. These techniques have marked differences in dose distribution and homogeneity. The published range of local recurrence rates varies between 0% to 37%, the median follow‐up from 8 to 72 months. CONCLUSIONS. To date, follow‐up times mostly do not yet permit a definite judgment concerning the long‐term effectiveness and side effects of APBI. The relevant societies in Germany support randomized clinical studies comparing APBI with WBRT in a well‐defined subset of low‐risk patients. However, the authors expressly discourage the routine use of APBI outside clinical trials. Until definite results show that APBI neither impairs therapeutic outcome nor cosmetic results, WBRT remains the gold standard in the treatment of early breast cancer. Cancer 2007. © 2007 American Cancer Society.

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The Salzburg concept of intraoperative radiotherapy for breast cancer: Results and considerations

Reitsamer

Sedlmayer

Kopp

et al. 2006

Intl Journal of Cancer

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Aim of this study is to show that ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery can be reduced by proper surgery and modern radiotherapy techniques. Three hundred and seventy eight women with stage I or II breast cancer had breast conserving surgery and received 51-56.1 Gy of postoperative radiation to the whole breast in 1.7 Gy fractions, but patients received different boost strategies. Group 1 (n 5 188) received electron boost radiation of 12 Gy subsequent to the irradiation to the whole breast, group 2 (n 5 190) received intraoperative electron boost radiation of 9 Gy directly to the tumor bed, followed by whole breast irradiation. After a median follow up period of 81.0 months in group 1 and a median follow up period of 51.1 months in group 2, 12 IBTRs (6.4%) could be observed in group 1 and no IBTR could be observed in group 2 (0.0%). The 5-year actuarial rates of IBTR were 4.3% (95% CI, 1.9-8.3%) and 0.0% (95% CI, 0.0-1.9%), respectively (p 5 0.0018). The 5-year actuarial rates of distant recurrence were 8.6% (95% CI, 4.9-13.5%) and 4.2% (95% CI, 1.8-8.2%), respectively (p 5 0.08). The 5 year disease-free survival rates were 90.9% (95% CI, 85.8-94.7%) in group 1 and 95.8% (95% CI, 91.8-98.2%) in group 2 (p 5 0.064). Immediate IORT-boost and whole breast irradiation yields excellent local control at 5 years, and was associated with a statistically significant decreased rate of IBTR compared with a similar cohort of patients treated with whole breast irradiation and conventional electron boost. ' 2005 Wiley-Liss, Inc.

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Radiotherapy Confined to the Tumor Bed Following Breast Conserving Surgery

Cited by 49 publications

References 48 publications

Az Orvosi Hetilap 2003 márciusi lapszámai

Az Orvosi Hetilap 2003 márciusi lapszámai

Accelerated partial breast irradiation

The Salzburg concept of intraoperative radiotherapy for breast cancer: Results and considerations

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