Radiotherapy does not impair dentin adhesive properties in head and neck cancer patients

Galetti, Roberta; Santos‐Silva, Alan Roger; Antunes, Alberto Nogueira da Gama; Alves, Fábio de Abreu; Lopes, Márcio Ajudarte; Goes, M F De

doi:10.1007/s00784-013-1155-4

Cited by 33 publications

(41 citation statements)

References 24 publications

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“…Therefore, the current results also support that HNRT does not affect the histological pathways of dentin caries progress in cancer patients [Silva et al, 2009]. This finding also reinforces the contemporary concept that radiation does not impair dentin bond strength, indicating that HNRT patients can be subjected to conventional adhesive restorative procedures [Silva et al, 2010;Galetti et al, 2014].…”

Section: Discussionsupporting

confidence: 77%

Postradiation Matrix Metalloproteinase-20 Expression and Its Impact on Dental Micromorphology and Radiation-Related Caries

Gomes-Silva

Prado‐Ribeiro²,

Brandão³

et al. 2017

Caries Res

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Recent evidence suggests that head-and-neck radiotherapy (HNRT) increases active forms of matrix metalloproteinase-20 (MMP-20) in human tooth crowns, degrading the dentin-enamel junction (DEJ) and leading to enamel delamination, which is a pivotal step in the formation of radiation-related caries (RRC). Additional participation of enzymatic degradation of organic matrix components in caries progression was attributed to MMP-20 in dentin. Therefore, the current study tested the hypothesis that MMP-20 is overexpressed in the DEJ, dentin-pulp complex components, and carious dentin of post-HNRT patients, leading to detectable micromorphological changes to the enamel and dentin. Thirty-six teeth were studied, including 19 post-HNRT specimens and 17 nonirradiated controls. Optical light microscopy was used to investigate the micromorphological components of the DEJ, dentin-pulp complex components, and carious dentin. The samples were divided into 2 subgroups: nondemineralized ground sections (n = 20) and demineralized histological sections (n = 16). In addition, immunohistochemical analysis using the immunoperoxidase technique was conducted to semiquantitatively assess MMP-20 expression in the DEJ, dentin-pulp complex components, and carious dentin. No apparent damage to the DEJ microstructure or other dentin-pulp complex components was observed and no statistically significant differences were detected in MMP-20 expression (p > 0.05) between the irradiated and control groups. This study rejected the hypothesis that MMP-20 is overexpressed in the DEJ, dentin-pulp complex components, and carious dentin of post-HNRT patients, leading to detectable micromorphological changes. Hence, direct effects of radiation may not be regarded as an independent factor to explain aggressive clinical patterns of RRC.

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Section: Discussionsupporting

confidence: 77%

Postradiation Matrix Metalloproteinase-20 Expression and Its Impact on Dental Micromorphology and Radiation-Related Caries

Gomes-Silva

Prado‐Ribeiro²,

Brandão³

et al. 2017

Caries Res

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“…Exclusion criteria were immature teeth, more than one canal, canal with moderate or accentuated curvature, calcifications in the pulp chamber, internal resorptions, previous endodontic treatment and metallic dental restorations, which could produce secondary radiation (Galetti et al . ). The teeth were stored in labelled plastic vials containing artificial saliva (pH 7.0, 37 ° C), renewed daily.…”

Section: Methodsmentioning

confidence: 97%

“…Nevertheless, it is known that the surrounding normal tissues are hardly ever preserved during head and neck radiotherapy (Galetti et al . , Khaw et al . ).…”

Section: Introductionmentioning

confidence: 99%

Influence of therapeutic cancer radiation on the bond strength of an epoxy‐ or an MTA‐based sealer to root dentine

et al. 2015

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“…Embora o tratamento radioterápico seja realizado da maneira mais conservadora possível (FLETCHER, 1988;FERGUSON;STEVENS, 2007; JOINER; VAN DER KOGEL, 2009), dificilmente tecidos circunvizinhos sadios, como osso, mucosa, dentes e glândulas salivares, são preservados (KIELBASSA et al, 2006;FRÄNZEL;GERLACH, 2009;BRODY, 2013;GALETTI et al, 2014;KHAW et al, 2014). Os efeitos colaterais podem ser temporários, como perda de paladar, dor e sensibilidade de tecidos moles, infecções fúngicas, mucosite, osteorradionecrose dos maxilares, alterações no fluxo, secreção e composição da saliva; ou permanentes, como trismo, atrofia muscular na região dos maxilares e alterações na microbiota bacteriana (JANSMA et al, 1988;KIELBASSA et al,1997;FERGUSON;STEVENS, 2007;EPSTEIN;BENSADOUN, 2012;MCCAUL, 2012;KHAW et al, 2014).…”

Section: Introductionunclassified

Efeito da cabodiimida e da clorexidina na longevidade da resistência de união de cimento resinoso à dentina radicular e na composição química e estrutura do colágeno dentinário após radioterapia

Lopes¹

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Anna Akkus, além de conhecer diferentes métodos muito utilizados na Engenharia para análise de polímeros como o Analisador Termogravimétrico (TGA).Em colaboração, venho também participando de forma intensa de projetos de pesquisa, teses e dissertações envolvendo outras metodologias na área de Endodontia, entre elas análises morfológicas em microscópio confocal a laser e microscópio eletrônica de varredura, testes de propriedades físico-químicas de cimentos endodônticos, microbiologia, além de testes mecânicos em Máquina Universal de Ensaios, o que me possibilitou uma vivência mais ampla de diferentes métodos e linhas de pesquisa na Odontologia Restauradora. Esses projetos de pesquisa têm sido publicados com o grupo de pesquisa da FORP/USP na forma de artigos em periódicos de circulação internacional (

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Radiotherapy does not impair dentin adhesive properties in head and neck cancer patients

Abstract: Head and neck radiotherapy did not affect dentin bond strength for the adhesive materials tested in this study.

Cited by 33 publications

References 24 publications

Postradiation Matrix Metalloproteinase-20 Expression and Its Impact on Dental Micromorphology and Radiation-Related Caries

Postradiation Matrix Metalloproteinase-20 Expression and Its Impact on Dental Micromorphology and Radiation-Related Caries

Influence of therapeutic cancer radiation on the bond strength of an epoxy‐ or an MTA‐based sealer to root dentine

Efeito da cabodiimida e da clorexidina na longevidade da resistência de união de cimento resinoso à dentina radicular e na composição química e estrutura do colágeno dentinário após radioterapia

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