Radiotherapy for childhood cancer and subsequent thyroid cancer risk: a systematic review

Lorenz, Eva; Scholz-Kreisel, Peter; Baaken, Dan; Pokora, Roman; Blettner, Maria

doi:10.1007/s10654-018-0467-8

Cited by 16 publications

(20 citation statements)

References 49 publications

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“…[27][28][29] RAI treatment and EBRT have known potential carcinogenic effects. 30,31 However, in a recent meta-analysis report, RAI was not found to increase the risk of secondary primary breast cancer in thyroid cancer survivors. 32 Thyroid cancer is known to occur after radiotherapy in childhood cancers.…”

Section: Discussionmentioning

confidence: 95%

“…However, in a recent meta‐analysis report, RAI was not found to increase the risk of secondary primary breast cancer in thyroid cancer survivors 32 . Thyroid cancer is known to occur after radiotherapy in childhood cancers 31,33,34 . A systemic review and meta‐analysis of 762 468 patients found that radiotherapy for breast cancer is significantly associated with a 12% increased risk of nonbreast cancer, but there was no significantly increased risk of a subsequent thyroid cancer 35 .…”

Section: Discussionmentioning

confidence: 98%

“…32 Thyroid cancer is known to occur after radiotherapy in childhood cancers. 31,33,34 A systemic review and meta-analysis of 762 468 patients found that radiotherapy for breast cancer is significantly associated with a 12% increased risk of nonbreast cancer, but there was no significantly increased risk of a subsequent thyroid cancer. 35 Likewise, a recent study from the SEER database showed that radiation was not significantly associated with the development of DPMs after H and N cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Key potential etiological factors included the role of iodine transport, obesity, sex hormones, thyroid hormone, and carcinogenic treatment for each of the cancer types 27–29 . RAI treatment and EBRT have known potential carcinogenic effects 30,31 . However, in a recent meta‐analysis report, RAI was not found to increase the risk of secondary primary breast cancer in thyroid cancer survivors 32 .…”

Section: Discussionmentioning

confidence: 99%

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Analysis of overall survival in differentiated thyroid cancer patients with double primary malignancy

Chi

Wang

et al. 2020

The Kaohsiung J of Med Scie

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Differentiated thyroid cancer (DTC) survivors are at increased risk of developing double primary malignancy (DPM). The aim of this study was to investigate clinicopathological characteristics and survival in DTC patients diagnosed with DPM. A total of 975 patients with DTC diagnosed between 2013 and 2017, treated, and followed at a medical center in Taiwan were retrospectively reviewed. Data from enrolled patients were analyzed for differences in prognosis dependent on the presence of DPM, and which clinicopathological variables affected their prognosis. Among 975 thyroid cancer patients, 94 (9.6%) were diagnosed with DPMs and 16 (1.6%) patients died of any cause. DPM patients had a greater proportion of males, had a higher mean age, more commonly presented with a thyroid mass incidentally by imaging and cervical lymph node metastases, showed a more advanced thyroid cancer stage, and had a higher proportion of lymph node metastases. Overall survival (OS) was significantly lower in patients diagnosed with DPM. Male gender (hazard ratio [HR] = 4.597), two or more DPMs (HR = 8.071), and shorter time interval between two cancers occurrences (HR = 7.101) were significantly risk factors for DPM-related death. In conclusion, the risk of developing DPM in DTC patients was elevated in older, male patients with an advanced tumor-node-metastasis stage. DPM adversely affected the OS of thyroid cancer patients. Male gender, two or more DPMs, and shorter time interval between occurrences were significant risk factors for OS in DPM patients.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Analysis of overall survival in differentiated thyroid cancer patients with double primary malignancy

Chi

Wang

et al. 2020

The Kaohsiung J of Med Scie

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“…Persons with a history of childhood neck radiation or familial thyroid cancer are at higher risk of cancer in the remaining thyroid tissue [4,19]. This should be factored into the choice of initial surgery with a total thyroidectomy being preferred.…”

Section: Patient-specific High-risk Factorsmentioning

confidence: 99%

Hemithyroidectomy for Thyroid Cancer: A Review

2020

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Thyroid cancer incidence is on the rise; however, fortunately, the death rate is stable. Most persons with well-differentiated thyroid cancer have a low risk of recurrence at the time of diagnosis and can expect a normal life expectancy. Over the last two decades, guidelines have recommended less aggressive therapy for low-risk cancer and a more personalized approach to treatment of thyroid cancer overall. The American Thyroid Association (ATA) and National Comprehensive Cancer Network (NCCN) thyroid cancer guidelines recommend hemithyroidectomy as an acceptable surgical treatment option for low-risk thyroid cancer. Given this change in treatment paradigms, an increasing number of people are undergoing hemithyroidectomy rather than total or near-total thyroidectomy as their primary surgical treatment of thyroid cancer. The postoperative follow-up of hemithyroidectomy patients differs from those who have undergone total or near-total thyroidectomy, and the long-term monitoring with imaging and biomarkers can also be different. This article reviews indications for hemithyroidectomy, as well as postoperative considerations and management recommendations for those who have undergone hemithyroidectomy.

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Thyroid Nodules in Children and Adolescents

Lee

2023

Thyroid FNA Cytology

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Radiotherapy for childhood cancer and subsequent thyroid cancer risk: a systematic review

Cited by 16 publications

References 49 publications

Analysis of overall survival in differentiated thyroid cancer patients with double primary malignancy

Analysis of overall survival in differentiated thyroid cancer patients with double primary malignancy

Hemithyroidectomy for Thyroid Cancer: A Review

Thyroid Nodules in Children and Adolescents

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