Radiotherapy for lung cancer in the elderly

Bayman, N.; Alam, Nooreen; Faivre-Finn, Corinne

doi:10.1016/j.lungcan.2009.12.004

Cited by 33 publications

(13 citation statements)

References 119 publications

(136 reference statements)

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“…A number of studies evaluating treatment for the elderly have shown that older patients are less likely to receive surgery or other therapies [16]. Radiotherapy has been shown to be effective and well tolerated in patients 80 years or older [24] and especially stereotactic radiotherapy seems suitable for the elderly fragile patients [15] leading to better results than what can be obtained by conventional radiotherapy [25].…”

Section: Discussionmentioning

confidence: 99%

Trends in lung cancer in elderly in Denmark, 1980–2012

et al. 2016

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Background Lung cancer is an increasing problem in the older patient population due to the improvement in life expectation of the Western population. In this study we examine trends in lung cancer incidence and mortality in Denmark from 1980 to 2012 with special focus on the elderly. Material and methods Lung cancer was defined as ICD-10 codes C33-34. Data derived from the NORDCAN database with comparable data on cancer incidence, mortality, prevalence, and relative survival in the Nordic countries, where the Danish data were delivered from the Danish Cancer Registry and the Danish Cause of Death Registry with follow-up for death or emigration until the end of 2013. Results In 2012, about 50% of lung cancers were diagnosed among persons aged 70 years or more. For men and women older than 75 years the incidence rates have been increasing and for those aged 80-84 years, the rates have doubled since 1980. Due to the poor survival, similar trends were seen in mortality rates. Over the period, the one-year relative survival rates almost doubled in patients aged 70 years or more, but still only 25% of the patients aged 80-89 years survived their lung cancer for one year. Conclusion The incidence of lung cancer is closely linked to the pattern of tobacco smoking with the differences between gender and age groups reflecting smoking behavior in birth cohorts. Elderly patients with lung cancer are a heterogeneous group in whom treatment should be offered according to comorbidity and a geriatric assessment.

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Section: Discussionmentioning

confidence: 99%

Trends in lung cancer in elderly in Denmark, 1980–2012

et al. 2016

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“…In many cases radiotherapy is a valuable method in the treatment of lung cancer, leading to better survival rates and better quality of life [1]. In other cases, treatment with chemotherapy, and in some cases with targeted chemotherapy such as Gefitinib, is beneficial [2,3].…”

Section: Introductionmentioning

confidence: 99%

CT-guided needle lung biopsy is possible during apneic oxygenation: a case series

Kjærgaard

Zepernick

Bergmann

et al. 2013

Multidiscip Respir Med

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BackgroundIt can be difficult to perform CT guided biopsy of small pulmonary nodules especially if the position is behind a costa or close to the diaphragm and respiratory movements may hamper the procedure. During apneic oxygenation with a pulmonary standstill these movements can be hindered.MethodsSix patients with decreased lung function and suspicious lung nodules are presented. Under general anesthesia including a muscle relaxant and a cuffed tube in the trachea CT guided biopsy was prepared. Just before the biopsy the ventilation mode was switched to a continuous positive airway pressure of 5–10 cm H2O, maintaining 100% oxygen delivery without ventilation. If the position of the lung nodule was inconvenient for biopsy the pressure was increased to up to 17 cm H2O to expand the lungs to a better biopsy position. After retrieving the biopsy controlled ventilation was re-established and a finishing control CT-scan was performed. Blood gas analyses were performed with few minutes interval.ResultsAll biopsies were diagnostic. All patients survived the procedure with no major complications, but 3 patients developed pneumothorax. The length of apneic oxygenation was median 10 minutes (8–10 minutes). No major changes in vital parameters were observed, and in all patients the peripheral oxygen saturation was 100% throughout the procedure. The arterial oxygen tension rose to very high values and the lowest pH was 7.18.ConclusionsIt is possible to perform lung biopsies in selected patients with decreased lung function during apneic oxygenation in at least 10 minutes in a safe way.

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“…Radiation therapy is often used concomitantly with chemotherapy for curative intent in patients with NSCLC who are ineligible for surgery [11]. Radiation therapy plays an important role in the curative and palliative care of elderly patients with lung cancer because these patients often present several comorbidities or a poor functional status, which exclude surgery and chemotherapy from the available treatment options [11]. The most common systemic adverse effects occurring with radiotherapy include loss of appetite, body hair loss, skin changes in the treated zone and altered sleep patterns.…”

Section: Diagnosis and Stagingmentioning

confidence: 99%

Exercise-Based Rehabilitation for People with Lung Cancer

Tremblay¹

2014

J Pulm Respir Med

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Lung cancer is the leading cause of cancer-related death worldwide. Patients living with lung cancer often experience severe physical and psychological symptoms including dyspnea, fatigue, anxiety, decreased exercise tolerance, muscle weakness and compromised health-related quality of life as a direct consequence of the disease or as an indirect consequence of the cancer therapy itself. As both screening and treatment modalities improve, the number of people living with a diagnosis of lung cancer is increasing. Consequently, management of cancer-related symptoms as well as improvement of overall quality of life and functional status become critical issues in lung cancer patients. Thus, during the last decade, a wide range of exercise prescriptions and training modalities has been proposed and an emerging literature has addressed the effects of exercise-based rehabilitation programs along the continuum of the disease. The aim of this review is to address the latest literature regarding the feasibility and effectiveness of exercise-based rehabilitation for patients with lung cancer receiving treatments (perioperative, during chemotherapy/radiation therapy or following them) or for patients with advanced diseases. We also address how the use of new technologies or training modalities such as home-based telerehabilitation or neuromuscular electrical stimulation appears to be a promising approach to improve accessibility and participation in exercisebased rehabilitation programs. Evidence from our review suggests that pre and post-operative exercise-based rehabilitation appear to be safe and effective approaches to use with patients with lung cancer and for those with advanced disease receiving chemotherapy/radiation therapy. Larger randomized controlled trials are needed to confirm the efficacy of exercise interventions in this population.

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Radiotherapy for lung cancer in the elderly

Cited by 33 publications

References 119 publications

Trends in lung cancer in elderly in Denmark, 1980–2012

Trends in lung cancer in elderly in Denmark, 1980–2012

CT-guided needle lung biopsy is possible during apneic oxygenation: a case series

Exercise-Based Rehabilitation for People with Lung Cancer

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