Radiotherapy for nasopharyngeal cancer

Blanchard, Pierre; Biau, J.; Huguet, F.; Racadot, S.; Berthold, C.; Wong-Hee-Kam, Stéphanie; Biston, M.C.; Maingon, P.

doi:10.1016/j.canrad.2021.08.009

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…[2] Owing to the unique location and proximity of the nasopharynx to critical neurovascular structures, surgical resection is difficult; consequently, RT is usually the primary treatment. [32,33] Although recent advances in therapy have been applied to prolong survival rates, many patients with NPC undergoing treatment still develop tumor metastasis and rapid tumor recurrence, resulting in poor survival outcomes. Identifying novel biological markers that are available for the diagnosis of NPC is imperative to overcome the limitations of conventional treatment for recurrent and metastatic NPC.…”

Section: Discussionmentioning

confidence: 99%

SYNPO2 upregulation is an unfavorable prognostic factor for nasopharyngeal carcinoma patients

et al. 2023

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Nasopharyngeal carcinoma (NPC) is the most common malignant neoplasm of the nasopharynx. Despite improvements in the clinical treatment strategies for NPC, NPC patients usually have poor survival rates because of late diagnosis, tumor metastasis, and recurrence. Therefore, the identification of potential diagnostic and prognostic markers for NPC is imperative. We investigated the differential expression of cell adhesion-related genes (gene ontology:0003779) and tumorigenesis-related genes (GSE12452) in patients with NPC. The correlations between synaptopodin-2 (SYNPO2) immune expression and clinicopathological features were analyzed using Pearson chi-square test. Multivariate analysis was performed using Cox proportional hazards model. SYNPO2 expression was significantly higher in NPC tumor tissues than in nontumor tissues. High SYNPO2 expression was significantly associated with the advanced disease stage (P = .006). Univariate analysis showed that high expression of SYNPO2 was associated with poor disease-specific survival, distal metastasis-free survival, and local recurrence-free survival in patients with NPC. Notably, our multivariate analysis demonstrated that high SYNPO2 expression was substantially correlated with inferior disease-specific survival (hazard ratio = 1.968, P = .012) and local recurrence-free survival (hazard ratio = 3.386, P = .001). Overall, our findings reveal that SYNPO2 may aid in the development of potential prognostic biomarkers for NPC patients.

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Section: Discussionmentioning

confidence: 99%

SYNPO2 upregulation is an unfavorable prognostic factor for nasopharyngeal carcinoma patients

et al. 2023

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“…the best treatment method [3]. The most important step in the treatment planning system (TPS), which is performed by an experienced radiation oncology specialist, is contouring of the tumor tissue (PTV) and the organs at risk (OARs) before starting the treatment, which can involve two imaging modalities: computed tomography (CT), magnetic resonance imaging (MRI), or both of them [4].…”

Section: Review Articlementioning

confidence: 99%

Convolutional neural networks in auto-segmentation of nasopharyngeal carcinoma tumor — a systematic review and meta-analysis

Zamanian,

Abedi

2024

Oncol Clin Pract

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Introduction. Segmentation is one of the main stages of the treatment planning system (TPS), especially in nasopharyngeal carcinoma (NPC), because it is very heterogeneous and penetrates the skull bone tissue. An automated method to reduce the workload and human error caused by the lack of expertise and perspective would be very helpful. This meta-analysis evaluated the ability of convolutional neural networks (CNNs) to plan auto-segmentation computed tomography (CT) and magnetic resonance imaging (MRI) modalities.Material and methods. Articles published in PubMed, Scholar, and Cochrane databases were examined. The risk of bias was evaluated by the QUADAS-2 tool. The dice similarity coefficient (DSC) as the effect size and standard error (SE) as the precision index were analyzed by random effects. To calculate the degree of heterogeneity and its agent, we used (I 2 and τ 2 ) and meta-regression analysis (p < 0.05). A funnel plot was used to check for publication bias.Results. In general, eight studies on CT and 12 on MRI modalities were selected from 3601 studies. The heterogeneity based on (I 2 and τ 2 ) and DSC values (with a 95% confidence interval) for CT and MRI modalities were 88.7% (τ 2 = 0.011), 0.67 (0.62-0.72), and 81.42% (τ 2 =0.01), 0.76 (0.72-0.80), respectively.Conclusions. CNNs' ability to segment both CT and MRI modalities is at a medium level, and its improvement can make it more suitable for clinical use.

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“…In the treatment of NPC, a total of 70Gy in 33–35 daily fractions is typically prescribed for gross disease. For the elective nodal basins, there is a range of acceptable doses from 46 to 60 Gy reported in the literature [45]. At Memorial Sloan Kettering Cancer Center, an elective dose of 50 Gy is typically used.…”

Section: Text Of Reviewmentioning

confidence: 99%

Radiation oncology for the rhinologist

Levyn,

Yang,

Lee

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review This comprehensive review explores evolving treatment strategies for sinonasal and nasopharyngeal malignancies. It analyzes the role of adjuvant radiotherapy, the potential of intensity-modulated proton therapy (IMPT), and the relevance of de-escalation strategies nasopharyngeal carcinoma (NPC). Additionally, it discusses hyperfractionation in re-irradiation in NPC. Recent findings Adjuvant radiotherapy remains pivotal for sinonasal tumors, improving locoregional control and survival, notably in squamous cell carcinomas, adenocarcinomas, and adenoid cystic carcinomas. IMPT promises enhanced outcomes by sparing healthy tissues, potentially improving patients’ quality of life. For select stage II/T3N0 NPC, radiotherapy alone offers comparable outcomes to concurrent chemoradiotherapy, with fewer adverse events and improved quality of life. Selective neck irradiation in NPC patients with uninvolved necks maintains oncologic outcomes while reducing late toxicity. Hyperfractionation in re-irradiation shows promise in lowering late toxicities and improving overall survival, particularly in undifferentiated sinonasal carcinomas. Summary This review underscores the significance of adjuvant radiotherapy and the potential of advanced radiation techniques in optimizing sinonasal and nasopharyngeal malignancy outcomes. It emphasizes evolving de-escalation methods and individualized, evidence-based approaches. Future research will further refine strategies for these challenging malignancies.

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Radiotherapy for nasopharyngeal cancer

Cited by 7 publications

References 36 publications

SYNPO2 upregulation is an unfavorable prognostic factor for nasopharyngeal carcinoma patients

SYNPO2 upregulation is an unfavorable prognostic factor for nasopharyngeal carcinoma patients

Convolutional neural networks in auto-segmentation of nasopharyngeal carcinoma tumor — a systematic review and meta-analysis

Radiation oncology for the rhinologist

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