Radiotherapy for parotid IgG4‐related disease

Abstract

We describe the use of radiotherapy for parotid IgG4-related disease (IgG4-RD), initially misdiagnosed as Kimura's disease, with sustained good partial response in a 37-year-old male. To the best of our knowledge, this is the first reported case of radiation for extra-orbital IgG4-RD, albeit inadvertently.

A unique case of IgG4-related skin disease and sclerosing cholangitis in a patient with previous hepatitis exposure

“…Of those, only 81 cases reported having obtained viral serologies for hepatitis, and 14 cases (17%) reported having obtained positive hepatitis serologies, indicating past or current infection ( Table I ). 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 Given that majority of the cases (87%) were not tested for hepatitis, the current literature remains limited and warrants future scientific investigation into the contribution of hepatitis to IgG4-RD.…”

“… 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 Given that majority of the cases (87%) were not tested for hepatitis, the current literature remains limited and warrants future scientific investigation into the contribution of hepatitis to IgG4-RD.…”

Stereotactic radiosurgery for intracranial IgG4‐related disease

“…Radio‐responsiveness of IgG4‐related disease has previously been demonstrated in several cases of orbital disease and one case of parotid gland IgG4‐related disease, in which the pathology was initially misdiagnosed as Kimura's disease …”

“…Other adjunctive treatments include use of other immunosuppressive agents such as methotrexate and azathioprine, and newer targeted therapies such as rituximab . Previously, the use of radiotherapy in the treatment of IgG4‐related disease has only been described in the context of orbital and parotid gland disease …”