Radiotherapy for stage I Hodgkin's disease: 20 years experience at St Bartholomew's Hospital

Ganesan, T. S.; Wrigley, P. F. M.; Murray, P; Stansfeld, A. G.; d'Ardenne, A J; Arnott, S.J.; Jones, Arthur; Shand, W. S.; Malpas, J. S.; Lister, T. Andrew

doi:10.1038/bjc.1990.285

Cited by 26 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A retrospective analysis of data compiled from PS IB-IIB patients showed that patients with night sweats alone and no other B symptoms had a prognosis no different from PS IA-IIA patients. Fevers and weight loss were independent risk 46 Staging Laparotomy in Hodgkin's Disease factors for survival, and their presence together conferred a significantly worse freedom from relapse and survival compared to patients with only one of these symptoms [69,129].…”

Section: Identification Of Prognostic Factors In Clinically Staged Pamentioning

confidence: 98%

“…Furthermore, pathologic staging may permit the use of smaller radiation fields. In a group of patients with pathologic early stage disease and other favorable prognostic factors (such as young age or nodular sclerosis or lymphocyte predominant histology), mantle field irradiation alone may be sufficient [14,40,45,46]. In those patients who still require subdiaphragmatic irradiation after laparotomy, splenectomy allows delivery of a smaller dose to the abdomen without jeopardizing the left kidney and lung base [6,9,10,47].…”

Section: The Role Of Staging Laparotomy In Hodgkin's Diseasementioning

confidence: 99%

See 1 more Smart Citation

Staging Laparotomy in the Management of Hodgkin's Disease: Is it Still Necessary?

Multani

Grossbard

1996

The Oncologist

View full text Add to dashboard Cite

Approximately 3,500 cases of stage I and II Hodgkin's disease are diagnosed each year in the United States. Traditionally, those patients who are considered candidates for primary radiation therapy undergo staging laparotomy (pathologic staging) to rule out definitively the presence of occult subdiaphragmatic disease. An appreciation of the risks of laparotomy and a recognition of the effectiveness of salvage chemotherapy in patients who fail primary radiation therapy have permitted the increased use of clinical staging as the basis for treatment of these patients. This article summarizes the literature regarding the need for staging laparotomy in early stage Hodgkin's disease and suggests alternative approaches to the management of these patients based on clinical criteria and prognostic factors.

show abstract

Section: Identification Of Prognostic Factors In Clinically Staged Pamentioning

confidence: 98%