Radiotherapy for stage I seminoma of the testis: Organ equivalent dose to partially in‐field structures and second cancer risk estimates on the basis of a mechanistic, bell‐shaped, and plateau model

Mazonakis, Michalis; Varveris, C.; Lyraraki, Efrossyni; Damilakis, John

doi:10.1118/1.4932394

Cited by 10 publications

(11 citation statements)

References 47 publications

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“…14 Previous studies have already reported large deviations between the mechanistic and bell-shaped models in the estimation of the radiotherapy-induced stomach cancer risk. 21,25 The assessments of the lifetime risks for lung cancer induction following ISRT for mediastinal HL were at least 1.8 times smaller than the baseline risks irrespective of the patient's age and the model used for analyzing the DVH data. The corresponding LARs of breast cancer incidence in females were found to be more than 5.3 times lower.…”

Section: Discussionmentioning

confidence: 99%

“…Reported experience suggested that the OED of esophagus used for estimating the relevant carcinogenic effects can be defined by using the model parameters of stomach . Previous studies have already reported large deviations between the mechanistic and bell‐shaped models in the estimation of the radiotherapy‐induced stomach cancer risk …”

Section: Discussionmentioning

confidence: 99%

“…18,19 The use of the organ equivalent dose (OED) instead of the D av is recommended for estimating the probability for the appearance of malignancies in organs exposed to high radiation doses. 19 The OED takes into account the cell sterilization effects and it has been previously employed to determine the probability for the appearance of secondary malignancies in both adult 14,20,21 and pediatric patients 22,23 undergoing external-beam radiotherapy. The OED was not calculated for thyroid gland which was entirely excluded from the treatment volume of all patients subjected to ISRT.…”

Section: C Organ Equivalent Doses From Isrtmentioning

confidence: 99%

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Second cancer risk assessments after involved-site radiotherapy for mediastinal Hodgkin lymphoma

2017

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: C Organ Equivalent Doses From Isrtmentioning

confidence: 99%

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Second cancer risk assessments after involved-site radiotherapy for mediastinal Hodgkin lymphoma

2017

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“…Among the more established risk factors for CRC are obesity, old age, physical inactivity, dietary habits, alcohol use, and smoking [10,43]. Cancer treatments such as chemotherapy and radiotherapy have also been implicated in the development of CRC [44][45][46][47][48][49]. These risk factors can also predispose patients to a variety of NCRCs and may explain the commonality among these cancers.…”

Section: Discussionmentioning

confidence: 99%

Patients with non-colorectal cancers may be at elevated risk of colorectal neoplasia

et al. 2020

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Background: Screening for colonic neoplasia has decreased the incidence of colorectal cancer in the United States in the past two decades. Whether personal history of noncolorectal cancer is a risk factor for colonic neoplasia has not been well studied. We assessed the risk of colorectal neoplasia in noncolorectal cancer survivors. Methods: We conducted a retrospective study of patients who had undergone colonoscopy for any indication between 2009 and 2018. Colonic adenoma detection rate and multivariate logistic regression were conducted to assess for the primary outcomes of the study. Results: The study included 9408 cancer patients and 3295 control patients. Colonic adenomas were detected in 4503 cancer patients (48%) and 950 cancer-free patients (29%). Histologic examination of these adenomas revealed tubulovillous features in 620 patients (5%) and villous in 153 (1%). High-grade dysplasia was detected in 1611 patients (13%). Invasive colorectal adenocarcinoma was detected in 455 patients (12%); this rate was highest in patients with multiple myeloma (14%). Multivariate analysis revealed that a personal history of noncolorectal cancer was associated with increased risk of adenoma (Odd ratio, 2.04; 95% CI, 1.84-2.26; P<0.001). The adenoma detection rate was 30% in patients younger than 40 years (n=1211), 32% in patients between 41 and 50 years (n=812), 47% in patients between 51 and 60 years (n=2892), and 55% in patients older than 60 years (n=4493). Conclusions: The adenoma detection rate in patients with a personal history of noncolorectal cancer is higher than the reported rate of the general population and our control group.

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“…According to the literature, the main problem arising from the use of IMRT is an increased risk of secondary malignancies [ 24 – 29 ], and from proton therapy, limited availability of this therapeutic method. So far, we use the above methods in particular clinical situations in patients with GCT.…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy in testicular germ cell tumours – a literature review

Jońska-Gmyrek

Pęczkowski

Michalski

et al. 2017

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Testicular germ cell tumours (GCT) represent about 1–2% of malignant in men. The essential therapeutic option for early-stage GCT is radical orchiectomy (RO), except in situations that require immediate chemotherapy in patients with a massive dissemination and unequivocally elevated levels of tumour markers.Postoperative radiotherapy (PORT) in patients with testicular seminoma in Clinical Stage I (CS I) is one of the treatment options next to active surveillance (AS) and chemotherapy (CHTH). Regardless of the procedure, five-year survival in this group of patients ranges between 97% and 100%.In the article, we present the literature review pertinent to therapeutic options, with a focus on radiotherapy. We have searched MEDLINE (PubMed) for all studies on patients with GCT treated with radiation therapy during the last 20 years, and the current therapeutic recommendations. We used the following keywords: germ cell tumours, testis, seminoma, non-seminoma, radiotherapy, outcome.

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Radiotherapy for stage I seminoma of the testis: Organ equivalent dose to partially in‐field structures and second cancer risk estimates on the basis of a mechanistic, bell‐shaped, and plateau model

Abstract: Radiotherapy for stage I seminoma of the testis may result in an excess risk for the appearance of secondary malignancies in partially in-field organs. The organ- and model-dependent second cancer risk assessments of this study may be of value for patient counseling and follow-up.

Cited by 10 publications

References 47 publications

Second cancer risk assessments after involved-site radiotherapy for mediastinal Hodgkin lymphoma

Second cancer risk assessments after involved-site radiotherapy for mediastinal Hodgkin lymphoma

Patients with non-colorectal cancers may be at elevated risk of colorectal neoplasia

Radiotherapy in testicular germ cell tumours – a literature review

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