Radiotherapy for the treatment of optic nerve sheath meningioma: A systematic review and meta-analysis

Melo, Laísa Pereira de; Viani, Gustavo Arruda; Paula, Jayter Silva

doi:10.1016/j.radonc.2021.10.009

Cited by 15 publications

(7 citation statements)

References 49 publications

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“…A metanalysis by de Melo et al 6 reports that radiotherapy alone may improve vision in cases of optic nerve sheath meningioma; however, the location of meningioma in our cohort is more diverse. Thus, without decompression, the typical outcome of radiotherapy would be visual deterioration 5 .…”

Section: Discussionmentioning

confidence: 59%

“…The benefit of optic nerve decompression is therefore not described solely by post-operative vision improvement as in the traumatic nerve compression group, and postradiation visual outcome should also be recorded to fully appreciate the benefits of this surgery. A metanalysis by de Melo et al 6 reports that radiotherapy alone may improve vision in cases of optic nerve sheath meningioma; however, the location of meningioma in our cohort is more diverse. Thus, without decompression, the typical outcome of radiotherapy would be visual deterioration.…”

Section: Comparison With Other Studiesmentioning

confidence: 63%

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A novel adaptation of endoscopic optic nerve decompression in non‐traumatic optic neuropathy: A retrospective case series

Smith

Weir

et al. 2022

Clinical Otolaryngology

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The use of the endoscopic approach in cases of non-traumatic optic neuropathy is well documented in the literature. 1 This approach can also be of benefit in cases of visual loss from skull base meningiomas directly compressing the nerve. Specifically, the transnasal endoscopic approach affords excellent visualisation of the orbital apex and optic canal with minimal patient morbidity. | ObjectivesWe intend to highlight the benefits of our technique (which includes a posterior to anterior approach) and discuss the role of optic nerve sheath incision by reviewing visual outcomes and complications. | METHODS | Ethical considerationsThis was an audit of local practice and therefore did not require ethical approval. All patients involved were appropriately consented for the procedure. We used the CARE checklist when writing our report. 2

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Section: Discussionmentioning

confidence: 59%

Section: Comparison With Other Studiesmentioning

confidence: 63%

A novel adaptation of endoscopic optic nerve decompression in non‐traumatic optic neuropathy: A retrospective case series

Smith

Weir

et al. 2022

Clinical Otolaryngology

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“…17 The majority of existing literatures indicate that FSRT is the treatment of choice for PONSM because of its high efficacy and low incidence of complications. 1,10,12,[18][19][20] There were some limitations in previous studies. 1,3,5,18,19 First, they did not exclude PONSM subjects who had a history of tumor biopsy/resection.…”

Section: Introductionmentioning

confidence: 99%

“… 17 The majority of existing literatures indicate that FSRT is the treatment of choice for PONSM because of its high efficacy and low incidence of complications. 1 , 10 , 12 , 18–20 …”

Section: Introductionmentioning

confidence: 99%

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Long-Term Visual Function After Fractionated Stereotactic Radiotherapy for Primary Optic Nerve Sheath Meningioma: A Retrospective Analysis of 34 Subjects

Vanikieti¹,

Chaiwithooanukul²,

Puataweepong³

et al. 2022

OPTH

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Objective To evaluate long-term visual function after fractionated stereotactic radiotherapy (FSRT) for primary optic nerve sheath meningioma (PONSM). Methods This 22-year retrospective study included 34 subjects (34 affected eyes) with PONSM who were treated with FSRT exclusively. Subjects with a history of biopsy/resection were excluded. Visual function, including visual acuity (VA) and visual field mean deviation (VF MD), was evaluated at presentation (pre-radiotherapy; pre-RT) and at the final follow-up (post-radiotherapy; post-RT); treatment complications were also evaluated. Treatment success was defined as either stabilization or improvement of visual function. Results The median pre-RT VA and pre-RT VF MD were 0.70 logarithm of the minimum angle of resolution (logMAR; range: 0.0–2.9 logMAR) and −15.4 decibels (dB) (range: −31.4 to −3.2 dB), respectively. The median total dose of FSRT was 50 Gy (range: 45–54 Gy) and the median number of fractions was 25 (range: 25–30). The median follow-up interval was 89 months (range: 6–251 months). The median post-RT VA and post-RT VF MD were 0.48 logMAR (range: 0.0–2.9 logMAR) ( p = 0.010) and −6.8 dB (range: −20.6 to −1.6 dB) ( p = 0.005), respectively. Among the 34 included eyes, VA was successfully treated in 29 eyes (85.3%) and worsened in 5 eyes (14.7%). Of the 14 eyes with both VA and reliable VF MD at pre-RT and post-RT time points, VF MD was successfully treated in 13 eyes (92.8%) and worsened in one (7.2%); overall visual function was successfully treated in 13 eyes (92.8%) and worsened in 1 eye (7.2%). Complications occurred in one subject (2.9%; radiation retinopathy). Conclusion Approximately 90% of PONSM subjects exhibited long-term treatment success in terms of VA, VF MD, and overall visual function after FSRT. Additionally, the incidence of complications was low. Therefore, FSRT is effective and safe treatment for PONSM.

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Tumors of the Optic Nerve and Its Sheath

Maiuri,

Tranfa,

Bonavolontà

et al. 2023

Cranio-Orbital Mass Lesions

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Radiotherapy for the treatment of optic nerve sheath meningioma: A systematic review and meta-analysis

Cited by 15 publications

References 49 publications

A novel adaptation of endoscopic optic nerve decompression in non‐traumatic optic neuropathy: A retrospective case series

A novel adaptation of endoscopic optic nerve decompression in non‐traumatic optic neuropathy: A retrospective case series

Long-Term Visual Function After Fractionated Stereotactic Radiotherapy for Primary Optic Nerve Sheath Meningioma: A Retrospective Analysis of 34 Subjects

Tumors of the Optic Nerve and Its Sheath

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