Radiotherapy in epithelial tumors of the parotid gland: Case presentation and literature review

The role of radiotherapy in the treatment of malignant salivary gland tumors

“…However, recurrences after 5 years were seen. This figure is more favorable than those reported by others using conventional photon or electron therapy, with locoregional control rates in these studies of around 25% (10,15,29,30). Accelerated hyperfractionated photon therapy for a total dose of 65-70 Gy may result in a local control rate of 85%, as shown by Wang et al (9).…”

Recurrent pleomorphic adenoma of the parotid gland: Institutional experience and review of the literature

“…For example, according to Leonetti et al radical surgery including facial nerve sacrifice results in 0% recurrences in comparison to 18% when nerve sparing is performed ; Another study by Carew et al reported on up to 94% tumor control when radical surgery is performed (without referring to the facial nerve involvement) . In contrast, Piorkowski and Guillamondegui et al and Renehan et al conclude that the type of surgical procedure in the recurrent PA scenario will not affect tumor control; again with no details on the surgical extent or number of the recurrent cases while Wittekind and Zbären et al did correlate extent of surgery with tumor control without describing the precise extent of surgery used or numbers to support their conclusion . The question of choosing adequate surgery may seriously endanger the facial nerve, especially after radical surgery in an already operated field; it has been previously reported that post‐operational facial nerve damage more common in recurrent cases than after the initial operation.…”

“…Reviewing the literature, one can see that the use of radiation therapy as an adjuvant to surgery decreases the risk of subsequent recurrence. In some studies, postoperative radiotherapy results in an excellent local control . Yet, the use of radiotherapy remains controversial in the management of benign recurrent disease.…”

Benign parotid adenomas: A review of the princess margaret hospital experience

“…The medical records of 128 patients registered at Princess Margaret Hospital (PMH) coded with a diagnosis of benign parotid tumor from January 1, 1970 t o December 31, 1987 were reviewed. Fifty-two patients were excluded from this review due to the following reasons: Warthin's tumor (14), tumor actually originated from either the minor salivary or submandibular glands (121, no follow-up information available (lo), other benign pathologies such as Sjogren's syndrome and lymphoid hyperplasia (7), patients received XRT elsewhere (5), or the diagnosis was later altered to cancer (4). Thus, 76 patients remained for this analysis of benign parotid adenomas.…”

“…Appropriate initial treatment of benign parotid tumors is a complete surgical excision, ie, parotidectomy, as there is a high recurrence rate of up to 80% after a mere en~cleation.~'~ In these recurrent situations, postoperative radiotherapy (XRT) can be administered, with excellent local control rates exceeding 95%. [3][4][5][6] The use of XRT in such cases, however, has to be balanced by the potential longterm risk of malignancies either in the remaining ipsilateral parotid tissue itself or elsewhere in the headheck Because the median age for this population is young, usually in the fifth decade,' the concern of a radiation-induced malignancy is real given the number of years that these patients are at risk for, and the nonfatal nature of such tumors. Therefore, we undertook this review to establish the long-term outcome in terms of local control and complication rates in patients with parotid adenomas managed at our institution.…”