Radiotherapy in the management of malignant melanoma

Lobo, P. A.; Liebner, Edwin J.; Chao, John Jen-Hung; Kanji, A.M.

doi:10.1016/0360-3016(81)90055-9

Cited by 70 publications

(12 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Radiation therapy for metastases to the skin, soft tissue, and lymph nodes has also been described in smaller patient groups by 6 further studies [93,413,529,[531][532][533]. Here, cumulative doses of mostly 30 to 40 Gy were employed yielding objective response rates between 45 % and 80 % as well as beneficial palliative effects.…”

Section: P Kurschatmentioning

confidence: 99%

“…Systematic search of the literature de-novo: [93,[412][413][414][528][529][530][531][532][533] Strength of consensus: 96 %…”

Section: Level Of Evidencementioning

confidence: 99%

“…There is a total of 10 case series and retrospective analyses, partly with larger patient groups, on radiation therapy in stage IV melanoma metastases to the skin, subcutis, or lymph nodes [93,[412][413][414][528][529][530][531][532][533]. Frequently, however, the primary study objective was not the efficacy of radiation therapy, but rather the effect of additional measures such as hyperthermia.…”

Section: P Kurschatmentioning

confidence: 99%

“…lungs or liver, has been described in only 5 studies [93,413,414,529,532]. Seegenschmied et al treated 19 pulmonary and 9 hepatic lesions, but they did not break down their findings according to individual sites.…”

Section: P Kurschatmentioning

confidence: 99%

See 3 more Smart Citations

Malignant Melanoma S3‐Guideline “Diagnosis, Therapy and Follow‐up of Melanoma”

Pflugfelder

Kochs

Blum

et al. 2013

J Deutsche Derma Gesell

181

148

View full text Add to dashboard Cite

Section: P Kurschatmentioning

confidence: 99%

“…Systematic search of the literature de-novo: [93,[412][413][414][528][529][530][531][532][533] Strength of consensus: 96 %…”

Section: Level Of Evidencementioning

confidence: 99%

Section: P Kurschatmentioning

confidence: 99%

Section: P Kurschatmentioning

confidence: 99%

See 2 more Smart Citations

Malignant Melanoma S3‐Guideline “Diagnosis, Therapy and Follow‐up of Melanoma”

Pflugfelder

Kochs

Blum

et al. 2013

J Deutsche Derma Gesell

181

148

View full text Add to dashboard Cite

“…Melanomas have often been classified as radioresistant (Fertil & Malaise, 1981;Deacon et al, 1984), but the radioresistance of melanomas has been questioned by several clinicians (Lobo et al, 1981;Trott et al, 1981). Recent reviews conclude that melanomas constitute a heterogeneous tumour group with very variable clinical radioresponsiveness (Habermalz, 1981;Harwood & Cummings, 1981;Rofstad, 1986).…”

Section: Resultsmentioning

confidence: 99%

Growth and radiosensitivity of malignant melanoma multicellular spheroids initiated directly from surgical specimens of tumours in man

Rofstad¹

1987

Br J Cancer

View full text Add to dashboard Cite

Summary The growth and radiosensitivity of multicellular spheroids initiated directly from disaggregated surgical specimens of four human malignant melanomas were studied. The spheroids were grown in liquidoverlay culture for up to 6 passages. Cell survival following irradiation was measured by using the Courtenay soft agar colony assay. The four melanomas formed spherical, densely packed spheroids. The volumetric growth rate as well as the plating efficiency in soft agar usually increased with increasing passage number. The radiosensitivity differed significantly among the melanomas. The survival curves for single cells from disaggregated spheroids in the first passage were always similar to those for single cells isolated directly from the surgical specimens. Two of the melanomas showed a significant contact effect as spheroids whereas the other two did not. The spheroids of two of the melanomas showed lower Do in the third and the sixth passage than in the first passage, whereas the spheroids of the other two melanomas showed similar survival curves in the first and the third passage. There was no clear relationship between the changes in radiosensitivity and the changes in growth rate or plating efficiency. It is concluded that spheroids in the first passage, but not spheroids in later passages, may have the potential to identify differences in clinical radioresponsiveness among tumours.

show abstract

Radiation Therapy as an Alternate Therapy for Locally Recurrent Acral Lentiginous Malignant Melanoma

et al. 1992

View full text Add to dashboard Cite

An 87-year-old white woman who was diagnosed in 1980 with malignant melanoma (MM) on the plantar aspect of her right foot (invasion, Clark level II; thickness, 0.7 mm) was referred to the dermatology clinic at the University of Texas Medical Branch, Galveston, 10 years after undergoing the initial surgery. A nonpigmented 1.1 \ m=x\0.6-cm shallow erosion overlaying the metatarsophalangeal joint ( Fig 1) was observed. Multiple 3-mm punch biopsy specimens of the erosion revealed an undifferentiated tumor adjacent to the epidermis that invaded the superficial dermis. Immunoperoxidase staining was positive for S100 protein and negative for keratin. The lymph nodes were not palpable, and no signs and symptoms of visceral metastatic disease were observed. Findings from her blood chemistry tests were within normal limits, except for borderline elevation of the alkaline phosphatase (279 U/L; normal, 68 to 243 U/L) and lactic dehydrogenase levels (207 U/L; normal, 109 to 193 U/L). The chest roentgenogram showed no evidence of metastatic tumor. The patient refused further evaluation for metastatic disease. She was classified as having acral lentiginous amelanotic MM of the right foot. After full dis¬ cussion of the treatment options available to her and the

show abstract

Radiotherapy in the management of malignant melanoma

Cited by 70 publications

References 4 publications

Malignant Melanoma S3‐Guideline “Diagnosis, Therapy and Follow‐up of Melanoma”

Malignant Melanoma S3‐Guideline “Diagnosis, Therapy and Follow‐up of Melanoma”

Growth and radiosensitivity of malignant melanoma multicellular spheroids initiated directly from surgical specimens of tumours in man

Radiation Therapy as an Alternate Therapy for Locally Recurrent Acral Lentiginous Malignant Melanoma

Contact Info

Product

Resources

About