2021
DOI: 10.3390/cells10020366
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Radiotherapy in the Management of Pediatric and Adult Osteosarcomas: A Multi-Institutional Cohort Analysis

Abstract: Background: Due to the rarity of osteosarcoma and limited indications for radiotherapy (RT), data on RT for this tumor are scarce. This study aimed to investigate the utilization of RT for osteosarcomas in the recent 20 years and to identify factors related to patients’ response to radiation. Methods: We performed a retrospective analysis of patients irradiated for osteosarcoma treatment. We planned to assess differences in the utilization of RT between the periods of 2000–2010 and 2011–2020, identify the risk… Show more

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Cited by 9 publications
(11 citation statements)
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“…These modalities increase the dose conformity within the target volume while achieving increased protection of healthy tissue. 44 Unique properties of charged particles, including proton and carbon ions, allow even further targeted dose delivery to anatomically complex areas. 45 These advancements have made RT a valuable treatment modality that has improved the arsenal to combat bone metastases, with a multi-institutional cohort analysis reporting 79.6% local control following an initial round of RT.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…These modalities increase the dose conformity within the target volume while achieving increased protection of healthy tissue. 44 Unique properties of charged particles, including proton and carbon ions, allow even further targeted dose delivery to anatomically complex areas. 45 These advancements have made RT a valuable treatment modality that has improved the arsenal to combat bone metastases, with a multi-institutional cohort analysis reporting 79.6% local control following an initial round of RT.…”
Section: Discussionmentioning
confidence: 99%
“…45 These advancements have made RT a valuable treatment modality that has improved the arsenal to combat bone metastases, with a multi-institutional cohort analysis reporting 79.6% local control following an initial round of RT. 44 Combinations of advanced RT with existing chemotherapeutic regiments have contributed to improved outcomes and enhanced the ability of surgeons to treat solitary metastatic disease. Manifestation of these advances and increased collaborative care were elucidated by Ratasvouri et al Utilizing the Scandinavian Sarcoma Group metastasis registry, they analyzed 672 operated non-spinal mets cases consisting of breast, prostate, lung, and kidney cancer and found in kidney cancer en bloc resection of solitary metastases was associated with a significant fourfold longer survival compared to intralesional surgery.…”
Section: Discussionmentioning
confidence: 99%
“…It remains a major challenge to further enhance the chemotherapy efficacy for osteosarcoma based on the classical MAP regimen. Secondly, with regard to radiotherapy for osteosarcoma, promisingly, the simple 2D-palliative radiotherapy has gradually transformed into a 3D-comformal radiotherapy since 2010 [24]. Radiotherapy is effective in some of the selected osteosarcoma patients.…”
Section: Discussionmentioning
confidence: 99%
“…Osteosarcoma is clinically regarded as a radioresistant cancer, and external beam radiotherapy is usually not effective for OS (26)(27)(28)(29). Unfortunately, the mechanisms of action related to the radioresistance are not well investigated and remain unresolved (30).…”
Section: Introductionmentioning
confidence: 99%