Radiotherapy in the management of glottic squamous cell carcinoma

Abstract

Introduction: Our purpose is to review the role radiotherapy (RT) in the treatment of glottic squamous cell carcinoma (SCC). Methods: A concise review of the pertinent literature. Results: RT cure rates are Tis-T1N0, 90% to 95%; T2N0, 70% to 80%; lowvolume T3-T4a, 65% to 70%. Concomitant cisplatin is given for T3-T4a SCCs. Severe complications occur in 1% to 2% for Tis-T2N0 and 10% for T3-T4a SCCs. Patients with high-volume T3-T4 SCCs undergo total laryngectomy, neck dissection, and postoperative RT. Those with positive margins and/or extranodal extension receive concomitant cisplatin. The likelihood of local-regional control at 5 years is 85% to 90%. Severe complications occur in 5% to 10%. Conclusions: RT is a good treatment option for patients with Tis-T2N0 and low-volume T3-T4a glottic SCCs. Patients with higher volume T3-T4 cancers are best treated with surgery and postoperative RT.

Clinical Outcomes of Curative Intent Radiotherapy by Helical Tomotherapy for Laryngeal Squamous Cell Carcinoma: A Retrospective Analysis in a Tertiary Referral Center

“…Radiotherapy and surgery, including technologies such as endoscopic resection or open partial laryngectomies, continue to be the primary recommendations for managing early-stage glottic cancer according to the National Comprehensive Cancer Network guidelines [ 15 ]. A review conducted by Mendenhall et al also reported that radiation therapy stands out as a favorable treatment choice for individuals diagnosed with early-stage and low-volume locally advanced stage LSCC [ 16 ]. In cases of higher volume cases, optimal management typically involves a combination of surgery followed by postoperative radiation therapy.…”

Oncologic effectiveness of open partial vertical laryngectomy in the treatment of early glottic cancer

“…Однако нельзя не обратить внимание на частое включение в исследования пациентов с весьма Diagnosis and treatment of head and neck tumors вариабельным местным распространением опухолевого процесса -от Tis до Т2 [9] и даже Т3 [8]. При таких неоднородных когортах больных экстраполировать общий показатель локального контроля на случаи с более распространенными опухолями вряд ли обоснованно, поскольку значимое снижение эффективности лечения при возрастании стадии опухоли (от Т1 к Т2) является хорошо задокументированным фактом при применении как эндоскопической [8,9], так и лучевой терапии [10]. Например, в исследовании D. De Seta и соавт.…”

Two rare cancers of the exocrine pancreas: to treat or not to treat like ductal adenocarcinoma?

“…Amongst all treatment modalities, using radiotherapy alone to treat ASCP patients resulted in the shortest median survival, estimated at just 2.3 months [102] . The relative insensitivity of ASCP to radiation therapy is somewhat surprising given that true squamous cell cancers are well known to have a higher sensitivity to radiation than adenocarcinoma and radiation can be used as definitive treatment in some clinical circumstances [105][106][107][108] . Although the population offered radiation alone may have been less fit than those offered other modalities confounding an accurate assessment of the absolute benefit of radiation, it is still clear that radiation will not serve as a potentially curative treatment in ASCP.…”