Radiotherapy-induced taste impairment

Redda, Maria Grazia Ruo; Allis, Simona

doi:10.1016/j.ctrv.2006.06.003

Cited by 112 publications

(79 citation statements)

References 42 publications

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“…This is followed by general abnormal taste and a reduction in taste acuity. 199,201,207,[209][210][211][212][213] Umami declines during the third week of RT. After RT, taste sensitivity usually recovers within several months after the resolution of mucosal damage.…”

Section: Taste Alterations In Cancermentioning

confidence: 99%

“…213 Zinc supplements may be considered in patients with persistent taste complaints. 209 Clonazepam may affect taste sensation. 236,237 Topical clonazepam has been used in the management of neuropathic oral conditions and anecdotal data in taste and smell complaints have been published.…”

Section: Managementmentioning

confidence: 99%

“…After RT, taste sensitivity usually recovers within several months after the resolution of mucosal damage. 184,209,211,[213][214][215][216][217][218] However, reduced taste sensitivity may continue indefinitely. Persisting taste loss may be due to damage to taste receptors 214,219 and hyposalivation.…”

Section: Taste Alterations In Cancermentioning

confidence: 99%

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Oral complications of cancer and cancer therapy

Epstein

Thariat

Bensadoun

et al. 2012

CA A Cancer J Clinicians

431

356

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Answer questions and earn CME/CNEOral complications resulting from cancer and cancer therapies cause acute and late toxicities that may be underreported, underrecognized, and undertreated. Recent advances in cancer treatment have led to changes in the incidence, nature, and severity of oral complications. As the number of survivors increases, it is becoming increasingly recognized that the aggressive management of oral toxicities is needed to ensure optimal long‐term oral health and general well‐being. Advances in care have had an impact on previously recognized oral complications and are leading to newly recognized adverse effects. Here, the authors briefly review advances in cancer therapy, including recent advances in surgery, oral care, radiation therapy, hematopoietic cell transplantation, and medical oncology; describe how these advances affect oral health; and discuss the frequent and/or severe oral health complications associated with cancer and cancer treatment and their effect upon long‐term health. Although some of the acute oral toxicities of cancer therapies may be reduced, they remain essentially unavoidable. The significant impact of long‐term complications requires increased awareness and recognition to promote prevention and appropriate intervention. It is therefore important for the primary oncologist to be aware of these complications so that appropriate measures can be implemented in a timely manner. Prevention and management is best provided via multidisciplinary health care teams, which must be integrated and communicate effectively in order to provide the best patient care in a coordinated manner at the appropriate time. CA Cancer J Clin 2012. © 2012 American Cancer Society.

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Section: Taste Alterations In Cancermentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

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Oral complications of cancer and cancer therapy

Epstein

Thariat

Bensadoun

et al. 2012

CA A Cancer J Clinicians

431

356

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“…However, normal tissue such as the salivary gland can not be excluded from the exposure field in many cases, depending on the irradiation procedure 1) . Long-term result of radiotherapy induces fibrosis of the acinar cells and a reduction in the salivary secretion, resulting in xerostomia 2) , dysphagia 3) , dental caries occurrence 4) , agenesia 5) , oral candidosis, malnutrition, and late effect such as osteoradionecrosis 6) , which adversely impacts patients' quality of life. In an attempt to prevent those complications, it is necessary to protect the healthy salivary glands.…”

Section: Introductionmentioning

confidence: 99%

Effects of Amifostine Administration Prior to Irradiation to the Submandibular Gland in Mice: Autoradiographic Study using 3H-leucine

Okumura

Nasu²,

Yosue

2009

Okajimas Folia Anat. Jpn.

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Summary:We histochemically investigated the radioprotection of organelle in acinus on the submandibular gland using amifostine. Mice were divided into those without amifostine administration or irradiation (group A), with amifostine administration and without irradiation (group B), without amifostine and with 5 Gy of irradiation (group C), and with amifostine and 5 Gy of irradiation (group D). In groups B and D were given 100 mg/kg of amifostine at 30 minutes prior to irradiation to the area equivalent to the submandibular gland. HE staining revealed that group D showed atrophy of the acinar cells, though the change was milder than that seen in group C. In AZAN-Mallory staining, fibrogenesis were found more often in group C as compared to the other groups. In Light Microscopic Autoradiography findings, the ratio of reduced silver particles in the acinar cells was lower in group C than in the other groups at 30 minutes after RI administration. Microstructure findings showed the findings were very similar to those of group A. In Electron microscopic Autoradiography, the ratio among the secretory granules was lower in group C at 120 minutes after RI administration. Our results indicate that amifostine can alleviate xerostomia caused by late effect from radiation.

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“…[4][5][6] Gustatory changes, particularly dysgeusia (abnormal or impaired sense of taste), is also caused by the physiological changes of cancer but often it is effect of cancer treatment. [7,8] Even though it is not life limiting, impaired taste is associated with poor nutritional intake, weight loss and consequently decreased quality of life. [8] Taste disorders are the major cause of malnutrition in the cancer patient, but it has been understudied and poorly addressed by health care professionals in the oncology setting.…”

Section: Introductionmentioning

confidence: 99%

Management of Dysgeusia related to Cancer

Munankarmi

2017

J Lumbini Med Coll

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a ----------------------------------------------- ABSTRACT:Introduction: Taste change due to cancer is a notorious side effect, adversely affecting appetite and weight. Even though taste change or dysgeusia is one of the major causes of poor nutritional status in cancer survivors, it is not addressed as a significant problem and is often left untreated. The main purpose of this review is to explore current knowledge of pharmacological and behavioral interventions for the treatment of cancer related taste change. Methods: This systematic review was conducted in accordance with PRISMA guidelines to identify original articles on taste change. Multiple databases including; Scopus, Medline, EMBASE, CINAHL, and all databases via Pro quest were searched for original articles or studies related to taste change caused by cancer or its treatment. Relevant articles were subjected to a full text evaluation and assessed by Critical appraisal skills program (CASP) guidelines and the Effective public health practice project (EPHPP) instrument. Results: The search revealed 12 eligible studies, six of which were randomized controlled trials. Most of the studies used a standardized validated tool to measure taste change. Dysgeusia is common in cancer, 14 to 100% cancer patient report it. Pharmacological management with zinc remains inconclusive as one study reports it as beneficial and two other studies reported null effect. Few studies suggested dietary modifications such as use of sugary, salty foods that are helpful to reduce the effect of dysgeusia. Conclusion: Dietary counseling and informing the patient well about self-care strategies before treatment has consistently shown positive results on taste change, with strong statistical power. Other potential treatments for dysgeusia such as zinc, amifostine, and megestrol acetate gave inconsistent results.

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Radiotherapy-induced taste impairment

Cited by 112 publications

References 42 publications

Oral complications of cancer and cancer therapy

Oral complications of cancer and cancer therapy

Effects of Amifostine Administration Prior to Irradiation to the Submandibular Gland in Mice: Autoradiographic Study using 3H-leucine

Management of Dysgeusia related to Cancer

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